Publications by Danilo Demarchi

Smart Portable Pen for Continuous Monitoring of Anaesthetics in Human Serum With Machine Learning

Sandro Carrara, Mandresy Ivan Ny Hanitra, Danilo Demarchi, Simone Aiassa

Continuous monitoring of anaesthetics infusion is demanded by anaesthesiologists to help in defining personalized dose, hence reducing risks and side effects. We propose the first piece of technology tailored explicitly to close the loop between anaesthesi ...

2021

Biosensors for Bimolecular Computing: a Review and Future Perspectives

Sandro Carrara, Danilo Demarchi, Simone Aiassa

Biomolecular computing is the field of engineering where computation, storage, communication, and coding are obtained by exploiting interactions between biomolecules, especially DNA, RNA, and enzymes. They are a promising solution in a long-term vision, br ...

SPRINGER2020

New Approach for Making Standard the Development of Biosensing Devices by a Modular Multi-Purpose Design

Sandro Carrara, Ioulia Tzouvadaki, Francesca Stradolini, Abuduwaili Tuoheti, Danilo Demarchi, Francesca Criscuolo, Simone Aiassa

The fast widening of biosensing applications, such as healthcare, drug delivery, food, and military industries, is increasing the need for generality and compatibility among different sensors. To address this challenge, we present here an innovative approa ...

2020

Miniaturised Wireless Power Transfer Systems for Neurostimulation: A Review

Sandro Carrara, Diego Ghezzi, Danilo Demarchi, Gian Luca Barbruni

In neurostimulation, wireless power transfer is an efficient technology to overcome several limitations affecting medical devices currently used in clinical practice. Several methods were developed over the years for wireless power transfer. In this review ...

2020

Pencil Graphite Needle-Shaped Biosensor for Anaesthetic Monitoring in Human Serum

Sandro Carrara, Danilo Demarchi, Simone Aiassa

Direct and online continuous monitoring of anaesthetic intake by the patient's blood stream improves practices in the critical procedure of anaesthesia. Several systems have been proposed to address this challenge. Electrochemical techniques are highly app ...

IEEE2020

New Measurement Method in Drug Sensing by Direct Total-Charge Detection in Voltammetry

Sandro Carrara, Danilo Demarchi, José David González Martínez, Simone Aiassa

Electrochemical biosensors are promoting point-of-care and wearable instrumentation due to their high versatility in measuring human metabolites. There is a considerable number of biological compounds that can be detected and measured through voltammetry b ...

IEEE2020

Continuous monitoring of propofol in human serum with fouling compensation by support vector classifier

Giovanni De Micheli, Sandro Carrara, Mandresy Ivan Ny Hanitra, Danilo Demarchi, Francesco Grassi, Francesca Criscuolo, Simone Aiassa, Tiberiu Totu, Gabriele Sandri

We present a new method for electrochemical sensing, which compensates the fouling effect of propofol through machine learning (ML) model. Direct and continuous monitoring of propofol is crucial in the development of automatic systems for control of drug i ...

Elsevier2020

Emulator Design and Generation of Synthetic Dataset in Multi-Ion Sensing

Giovanni De Micheli, Sandro Carrara, Mandresy Ivan Ny Hanitra, Danilo Demarchi

Multi-ion potentiometric sensing becomes challenging for mixed-ion samples in which interfering electrolytes significantly alter the response of each single sensor. Therefore, an emulator based on the phase-boundary potential model is proposed to simulate ...

IEEE2020

An Event-Driven Closed-Loop System for Real-Time FES Control

Silvestro Micera, Andrea Crema, Danilo Demarchi

Active functional rehabilitation procedures, exoskeleton application and prosthesis employment are essential tools for the society life reinstatement of subjects affected by neuromuscular disorders or victims of serious physical accident. In this paper we ...

IEEE2019

Live Demonstration: Quasi-Digital Portable Pen to Monitor Anaesthetics Delivery

Sandro Carrara, Danilo Demarchi, Francesco Grassi, Simone Aiassa

The live demonstration presents the innovative concept of a portable pen-device able to sense anaesthetic compounds over time for improved anaesthesiology practice. A custom Printed Circuit Board (PCB) manage in the event-based quasi-digital domain the sam ...

IEEE2019

Multi-panel, on-single-chip Memristive Biosensing

Giovanni De Micheli, Sandro Carrara, Ioulia Tzouvadaki, Abuduwaili Tuoheti, Danilo Demarchi

Memristive biosensors have demonstrated excellent capabilities for ultrasensitive bio-detection. In the present work, memristive biosensing chips are designed, fabricated and implemented in a for the first time presented multi-panel on-chip detection for d ...

2019

Quasi-Digital Biosensor-Interface for a Portable Pen to Monitor Anaesthetics Delivery

Sandro Carrara, Francesca Stradolini, Abuduwaili Tuoheti, Danilo Demarchi, Simone Aiassa

Monitoring of patient response to the anaesthetic drugs is an attractive improvement for achieving a correct balance of sedation level, increasing the chance of success in the right procedure of anaesthesia. Nowadays, there are no commercial tools able to ...

IEEE2019

Supplementary Material for "Optimized Sampling Rate for Voltammetry-Based Electrochemical Sensing in Wearable and IoT Applications"

Sandro Carrara, Danilo Demarchi, Simone Aiassa

The Voltammetry-Based Sensing (VBS) methods are extremely interesting due to high specificity in several biochemical applications. Several considerations can be applied to use this method to measure different analytes, and implement efficient and optimized ...

2019

Optimized Sampling Rate for Voltammetry-Based Electrochemical Sensing in Wearable and IoT Applications

Sandro Carrara, Danilo Demarchi, Simone Aiassa

The recent advancements in electrochemical measurements are guiding the development of new platforms for in situ point-of-care monitoring of human-metabolite, markers, and drugs. Despite this, the application of voltammetry-based sensing (VBS) techniques i ...

2019

Mixed gold and platinum nanostructured layers for all-solid-state ion sensors

Giovanni De Micheli, Sandro Carrara, Irene Taurino, Danilo Demarchi, Francesca Criscuolo, Lucia Lobello

The great interest in portable and wearable monitoring systems has promoted in recent years a major expansion of all-solid-state Ion-Selective Electrodes (ISEs). Nanostructured Solid-Contacts (SCs) have shown a promising potential in order to eliminate the ...

IEEE2018

IoT for Telemedicine Practices enabled by an Android (TM) Application with Cloud System Integration

Sandro Carrara, Thiébaud Modoux, Francesca Stradolini, Abuduwaili Tuoheti, Danilo Demarchi, Nadia Tamburrano

Connected medical devices are already paving the way towards the realization of Smart Hospitals where patient care is improved thanks to Internet of Things (IoT) solutions. Following this trend, in this paper we propose an IoT cloud-based network for anest ...

IEEE2018

Live Demonstration: An IoT Cloud-Based Architecture for Anesthesia Monitoring

Sandro Carrara, Thiébaud Modoux, Francesca Stradolini, Abuduwaili Tuoheti, Danilo Demarchi, Nadia Tamburrano

Medical Internet of Things (IoT) solutions are already paving the way towards the realization of Smart Hospitals. Following this trend, we propose an IoT cloud-based network for anesthesia on-line monitoring. This architecture allows the anesthesiologist t ...

IEEE2018

Raspberry-Pi based system for propofol monitoring

Sandro Carrara, Francesca Stradolini, Abuduwaili Tuoheti, Danilo Demarchi, Tugba Kilic

Induction of anesthesia with propofol is a largely adopted technique in hospital environments. The correct dosage of this compound is essential to avoid under- or over-anesthesia that may result in serious side-effects. Therefore, in clinical settings, lon ...

ELSEVIER SCIENCE BV2018

Portable Memristive Biosensing System as Effective Point-of-Care Device for Cancer Diagnostics

Giovanni De Micheli, Sandro Carrara, Ioulia Tzouvadaki, Abuduwaili Tuoheti, Danilo Demarchi

Memristive biosensors have been proved as excellent candidates for ultrasensitive biosensing. In this work, a novel portable bio-detection system based on memristive biosensors is designed, developed and tested for providing a significantly fast, automatic ...

IEEE2018

An IoT Solution for Online Monitoring of Anesthetics in Human Serum Based on an Integrated Fluidic Bioelectronic System

Giovanni De Micheli, Sandro Carrara, Francesca Stradolini, Abuduwaili Tuoheti, Danilo Demarchi, Tugba Kilic, Sofia Lydia Ntella, Nadia Tamburrano, Zijian Huang

In this paper, we present the design, the implementation and the validation of a novel Internet of Things (IoT) drug monitoring system for the online continuous and simultaneous detection of two main anesthetics, e.g., propofol and paracetamol, in undilute ...

2018