Publication

COUP-TFII Controls Mouse Pancreatic beta-Cell Mass through GLP-1-beta-Catenin Signaling Pathways

Anne Grapin-Botton
2012
Journal Articles

Abstract

Background: The control of the functional pancreatic beta-cell mass serves the key homeostatic function of releasing the right amount of insulin to keep blood sugar in the normal range. It is not fully understood though how beta-cell mass is determined.

Official source

https://infoscience.epfl.ch/entities/publication/1b58a10f-ef54-44c9-9a36-dc72917c13ea

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Anne Grapin-Botton
2012
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/1b58a10f-ef54-44c9-9a36-dc72917c13ea

About this result

Related concepts (20)

Blood sugar level

The blood sugar level, blood sugar concentration, blood glucose level, or glycemia, is the measure of glucose concentrated in the blood. The body tightly regulates blood glucose levels as a part of metabolic homeostasis. For a 70 kg (154 lb) human, approximately four grams of dissolved glucose (also called "blood glucose") is maintained in the blood plasma at all times.

Beta cell

Beta cells (β-cells) are a type of cell found in pancreatic islets that synthesize and secrete insulin and amylin. Beta cells make up 50–70% of the cells in human islets. In patients with Type 1 diabetes, beta-cell mass and function are diminished, leading to insufficient insulin secretion and hyperglycemia. The primary function of a beta cell is to produce and release insulin and amylin. Both are hormones which reduce blood glucose levels by different mechanisms.

Pancreatic beta cell function

Pancreatic beta cell function (synonyms Gβ or, if calculated from fasting concentrations of insulin and glucose, HOMA-Beta or SPINA-GBeta) is one of the preconditions of euglycaemia, i.e. normal blood sugar regulation. It is defined as insulin secretory capacity, i.e. the maximum amount of insulin to be produced by beta cells in a given unit of time. Beta cells play a paramount role in glucose homeostasis. Progressive loss of insulin secretory capacity is a key defect associated with the transition from a healthy glycaemic state to hyperglycaemia, characteristic of untreated diabetes mellitus.

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