Publication

Planar Cell Polarity Controls Pancreatic Endocrine Differentiation

Cédric Cortijo
2012
Theses

Abstract

PCP proteins are restricted to progenitor cells in the embryonic pancreas. The PCP core components Celsr2/3 control endocrine cell differentiation. This effect is mediated by the JNK pathway

Official source

https://infoscience.epfl.ch/entities/publication/2261bbdb-42de-44a9-8185-40a33f208c36

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Cédric Cortijo
2012
Theses

Abstract

PCP proteins are restricted to progenitor cells in the embryonic pancreas. The PCP core components Celsr2/3 control endocrine cell differentiation. This effect is mediated by the JNK pathway

Official source

https://infoscience.epfl.ch/entities/publication/2261bbdb-42de-44a9-8185-40a33f208c36

About this result

Related concepts (9)

Progenitor cell

A progenitor cell is a biological cell that can differentiate into a specific cell type. Stem cells and progenitor cells have this ability in common. However, stem cells are less specified than progenitor cells. Progenitor cells can only differentiate into their "target" cell type. The most important difference between stem cells and progenitor cells is that stem cells can replicate indefinitely, whereas progenitor cells can divide only a limited number of times. Controversy about the exact definition remains and the concept is still evolving.

Hematopoietic stem cell

Hematopoietic stem cells (HSCs) are the stem cells that give rise to other blood cells. This process is called haematopoiesis. In vertebrates, the very first definitive HSCs arise from the ventral endothelial wall of the embryonic aorta within the (midgestational) aorta-gonad-mesonephros region, through a process known as endothelial-to-hematopoietic transition. In adults, haematopoiesis occurs in the red bone marrow, in the core of most bones. The red bone marrow is derived from the layer of the embryo called the mesoderm.

Cell-mediated immunity

Cell-mediated immunity or cellular immunity is an immune response that does not involve antibodies. Rather, cell-mediated immunity is the activation of phagocytes, antigen-specific cytotoxic T-lymphocytes, and the release of various cytokines in response to an antigen. In the late 19th century Hippocratic tradition medicine system, the immune system was imagined into two branches: humoral immunity, for which the protective function of immunization could be found in the humor (cell-free bodily fluid or serum) and cellular immunity, for which the protective function of immunization was associated with cells.

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