Publication

Planar Cell Polarity Controls Pancreatic Endocrine Differentiation

Cédric Cortijo
2012
Theses

Résumé

PCP proteins are restricted to progenitor cells in the embryonic pancreas. The PCP core components Celsr2/3 control endocrine cell differentiation. This effect is mediated by the JNK pathway

Source officielle

https://infoscience.epfl.ch/entities/publication/2261bbdb-42de-44a9-8185-40a33f208c36

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Cédric Cortijo
2012
Theses

Résumé

PCP proteins are restricted to progenitor cells in the embryonic pancreas. The PCP core components Celsr2/3 control endocrine cell differentiation. This effect is mediated by the JNK pathway

Source officielle

https://infoscience.epfl.ch/entities/publication/2261bbdb-42de-44a9-8185-40a33f208c36

À propos de ce résultat

Concepts associés (9)

Progenitor cell

A progenitor cell is a biological cell that can differentiate into a specific cell type. Stem cells and progenitor cells have this ability in common. However, stem cells are less specified than progenitor cells. Progenitor cells can only differentiate into their "target" cell type. The most important difference between stem cells and progenitor cells is that stem cells can replicate indefinitely, whereas progenitor cells can divide only a limited number of times. Controversy about the exact definition remains and the concept is still evolving.

Cellule souche hématopoïétique

vignette|Schéma de différenciation cellulaire. Une cellule souche hématopoïétique (CSH, ou HSC, pour Hematopoietic stem cells en anglais) est un type de cellule primitive (cellule souche), qui ne représente qu'une infime fraction du tissu hématopoïétique, mais qui est à l'origine de toutes les lignées de cellules sanguines du corps. À la fois capable de s'auto-renouveler et se dupliquer, elle joue un rôle fondamental pour l'hématopoïèse.

Immunité cellulaire

Cell-mediated immunity or cellular immunity is an immune response that does not involve antibodies. Rather, cell-mediated immunity is the activation of phagocytes, antigen-specific cytotoxic T-lymphocytes, and the release of various cytokines in response to an antigen. In the late 19th century Hippocratic tradition medicine system, the immune system was imagined into two branches: humoral immunity, for which the protective function of immunization could be found in the humor (cell-free bodily fluid or serum) and cellular immunity, for which the protective function of immunization was associated with cells.

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Disruption of stem cell niche-confined R-spondin 3 expression leads to impaired hematopoiesis

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