Publication

On-Chip Sandwich Immunoassay in an Integrated Magneto-Optical CMOS Microsystem

Edoardo Charbon, Martinus Gijs, Ulrike Lehmann, Emile Dupont
2008
Conference Papers

Abstract

We report on an innovative approach to on-chip detection of single fluorescently-labeled magnetic micro-particles by means of Single Photon Avalanche Diode (SPAD) arrays. Our system enables particle separation through magnetic actuation and highly sensitive, high signal-to-noise-ratio detection with integrated SPADs. We will present the capability of our system to detect and quantitatively distinguish fluorescently labeled particles. This represents a first step towards a complete lab-on-a-chip system for specific antibody detection. The selection of magnetic micro-particles as the mobile substrate in a bio-assay is motivated by their growing impact on the lab-on-a-chip research area, fueled by their ability of contactless manipulation and a handling that is independent from biological processes.

Official source

https://infoscience.epfl.ch/entities/publication/2b644627-d5f5-4423-b1f3-9559aecc24db

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Edoardo Charbon, Martinus Gijs, Ulrike Lehmann, Emile Dupont
2008
Conference Papers

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/2b644627-d5f5-4423-b1f3-9559aecc24db

About this result

Related concepts (12)

Lab-on-a-chip

A lab-on-a-chip (LOC) is a device that integrates one or several laboratory functions on a single integrated circuit (commonly called a "chip") of only millimeters to a few square centimeters to achieve automation and high-throughput screening. LOCs can handle extremely small fluid volumes down to less than pico-liters. Lab-on-a-chip devices are a subset of microelectromechanical systems (MEMS) devices and sometimes called "micro total analysis systems" (μTAS). LOCs may use microfluidics, the physics, manipulation and study of minute amounts of fluids.

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