Publication

Mitochondrial ribosomal proteins as aging regulators

Johan Auwerx, Laurent Mouchiroud, Richardus Houtkooper
2013
Patents

Abstract

The present invention relates to methods of increasing lifespan, delaying aging, and/or preventing or treating an age-related disease or a mitochondrialdisease in a subject, comprising inducing a nuclear-mitochondrial OXPHOS protein dyssynchrony, including inhibiting the mitochondrial translation machinery function, as well as methods forscreening agents that are able to increase lifespan, inhibit or delay aging, and/or prevent or treat an age-related disease or disorder, or a mitochondrial disease or disorder, in a subject.

Official source

https://infoscience.epfl.ch/entities/publication/c508df2a-321a-4faf-8ae2-673daa34835e

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Johan Auwerx, Laurent Mouchiroud, Richardus Houtkooper
2013
Patents

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/c508df2a-321a-4faf-8ae2-673daa34835e

About this result

Related concepts (15)

Aging brain

Aging of the brain is a process of transformation of the brain in older age, including changes all individuals experience and those of illness (including unrecognised illness). Usually this refers to humans. Since life extension is only pertinent if accompanied by health span extension, and, more importantly, by preserving brain health and cognition, finding rejuvenating approaches that act simultaneously in peripheral tissues and in brain function is a key strategy for development of rejuvenating technology.

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Maximum life span (or, for humans, maximum reported age at death) is a measure of the maximum amount of time one or more members of a population have been observed to survive between birth and death. The term can also denote an estimate of the maximum amount of time that a member of a given species could survive between birth and death, provided circumstances that are optimal to that member's longevity. Most living species have an upper limit on the number of times somatic cells not expressing telomerase can divide.

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The anti-aging movement is a social movement devoted to eliminating or reversing aging, or reducing the effects of it. A substantial portion of the attention of the movement is on the possibilities for life extension, but there is also interest in techniques such as cosmetic surgery which ameliorate the effects of aging rather than delay or defeat it. There are many scientists of this movement with different approaches.

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