Homéostasie

Lothar Helm was born in Gernsbach (Germany) in 1952. He studied physics at the University of Karlsruhe (Germany) and obtained his diploma degree in 1977. He remained in Karlsruhe for his Ph.D. research with Prof. H. G. Hertz and received his degree in physical chemistry in 1980. In 1980 he joined the laboratories of Prof. André Merbach at the University of Lausanne, Switzerland. From 1983 to 2001 he was maître d’enseignement et de recherche at the Faculty of Science of the University of Lausanne. In 2001 he moved, together with the whole chemistry department, from the University of Lausanne to the Ecole Polytechnique Fédérale de Lausanne (EPFL). Since 2006 he is adjunct professor at the Institute of Chemical Sciences and Engineering at EPFL and director of the NMR services of the institute. From 2007 to 2011 he was director of the "Conférence du corps Enseignant" at EPFL. Since 2011 he is member of the School Assembly of EPFL (AE). MAIN RESEARCH INTERESTS: • Physico-chemical studies of contrast agents for medical magnetic resonance imaging (MRI) • Study of reactivity and reaction mechanisms in coordination chemistry by variable temperature and pressure nuclear magnetic resonance • Computer simulation of solvent dynamics on cations and metal complexes in solution Professional course

Johan Auwerx is Professor at the École Polytechnique Fédérale in Lausanne, Switzerland, where he occupies the Nestle Chair in Energy Metabolism. Dr. Auwerx has been using molecular physiology and systems genetics to understand metabolism in health, aging and disease. Much of his work focused on understanding how diet, exercise and hormones control metabolism through changing the expression of genes by altering the activity of transcription factors and their associated cofactors. His work was instrumental for the development of agonists of nuclear receptors - a particular class of transcription factors - into drugs, which now are used to treat high blood lipid levels, fatty liver, and type 2 diabetes. Dr. Auwerx was amongst the first to recognize that transcriptional cofactors, which fine-tune the activity of transcription factors, act as energy sensors/effectors that influence metabolic homeostasis. His research validated these cofactors as novel targets to treat metabolic diseases, and spurred the clinical use of natural compounds, such as resveratrol, as modulators of these cofactor pathways. Johan Auwerx was elected as a member of EMBO in 2003 and is the recipient of a dozen of international scientific prizes, including the Danone International Nutrition Award, the Oskar Minkowski Prize, and the Morgagni Gold Medal. His work is highly cited by his peers with a h-factor of over 100. He is an editorial board member of several journals, including Cell Metabolism, Molecular Systems Biology, The EMBO Journal, Journal of Cell Biology, Cell, and Science. Dr. Auwerx co-founded a handful of biotech companies, including Carex, PhytoDia, and most recently Mitobridge, and has served on several scientific advisory boards. Dr. Auwerx received both his MD and PhD in Molecular Endocrinology at the Katholieke Universiteit in Leuven, Belgium. He was a post-doctoral research fellow in the Departments of Medicine and Genetics of the University of Washington in Seattle.

Originaire de Pully (Vaud), André E. Merbach est né en 1940. Il étudie à l'Ecole Polytechnique de l'Université de Lausanne (Prix Pelet et de l'A3E2PL) et obtient son diplôme d'ingénieur chimiste en 1962 avec un travail de recherche en chimie organique. En 1964, l'Université de Lausanne lui confère le doctorat ès sciences avec félicitations du jury pour ses travaux sur les systèmes quaternaires de solubilité avec formation de cristaux mixtes. Il effectue ensuite un stage postdoctoral au Lawrence Radiation Laboratory de l'Université de Californie à Berkeley, où il étudie la ionisation d'électrolytes forts par RMN. En 1965, de retour à l'Institut de chimie minérale et analytique de l'UNIL, on lui demande de développer une recherche et de créer un enseignement en chimie de coordination. En 1971 il y est nommé professeur assistant. En 1973, la Société Suisse de Chimie lui attribue le Prix et la Médaille Werner pour ses travaux sur la structure, la stabilité et la dynamique d'adduits d'halogénures métalliques par RMN. Cette même année, l'UNIL le nomme professeur de chimie minérale et analytique. Il a été membre de la division mathématiques, des sciences naturelles et de l'ingénieur du Fonds national de la recherche scientifique (1985-1996). Il représente la Suisse au Comité Technique COST Chimie (Coopération Européenne dans le domaine scientifique et technique: 35 pays, 1000 groupes de recherche en chimie) et a présidé ce Comité de 1998 à 2000. Il a présidé le Comité de gestion européen pour l'Action COST D6 pour les "procédés et réactions chimiques dans des conditions extrêmes ou non classiques" (1992-1997). Il a organisé à Lausanne, en 1992, la XXIXe Conférence Internationale de Chimie de Coordination (ICCC). L'Université Lajos Kossuth, de Debrecen (Hongrie), lui a conféré, en 1993, le doctorat honoris causa pour ses études par RMN sous haute pression des mécanismes réactionnels en chimie de coordination. Il a été appelé à la présidence de la Société Suisse de Chimie (2001-2004). L'Université de Genève lui a délivré un doctorat honoris causa en 2003.

Awards: 1999 Young Investigator Award Plenary Lectureship , International Society for Neurochemistry 2011 Fellow , ESMRMB 2011 Teaching Award , Section Sciences de la Vie, EPFL

Daniel Favrat a obtenu à l'EPFL son diplôme d'ingénieur mécanicien en 1972 et le titre de docteur ès sciences techniques en 1976. Il passe ensuite 12 ans dans des centres de recherche industriels au Canada et en Suisse.Depuis 1988, D. Favrat est professeur et directeur du Laboratoire d'énergétique industrielle à l'EPFL. Il est aussi successivement directeur de l'Institut des Sciences de l'énergie et, dès janvier 2007, de l'Institut de Génie Mécanique. Ses recherches portent sur les analyses systémiques prenant en compte l'énergétique, l'environnement et l'économie (optimisation environomique), et les systèmes avancés pour une utilisation plus rationnelle de l'énergie (pompes à chaleur, moteurs, piles à combustible,turbomachines etc.) Il est membre de l'Académie Suisse des Sciences Techniques et vice-président du comité énergie de la Fédération Mondiale des Organisations d'Ingénieurs. Il est éditeur associé du journal "Energy" et l'auteur de deux livres sur la thermodynamique et l'énergétique publiés aux Presses Polytechniques Universitaires Romandes.

Pierre J. Magistretti is an internationally-recognized neuroscientist who has made significant contributions in the field of brain energy metabolism. His group has discovered some of the cellular and molecular mechanisms that underlie the coupling between neuronal activity and energy consumption by the brain. This work has considerable ramifications for the understanding of the origin of the signals detected with the current functional brain imaging techniques used in neurological and psychiatric research (see for example Magistretti et al, Science, 283: 496 – 497, 1999). He is the author of over 100 articles published in peer-reviewed journals. He has given over 80 invited lectures at international meetings or at universities in Europe and North America, including the 2000 Talairach Lecture at the “Functional Mapping of the Human Brain Conference”. In November 2000 he has been a “Mc Donnel Visiting Scholar” at Washington University School of Medicine. Pierre J. Magistretti is the President-Elect (2002 – 2004) of the Federation of European Neuroscience Societies (FENS) which has a membership of over 15000 European neuroscientists. He has been first president of the Swiss Society for Neuroscience (1997-1999) and the first Chairman of the Department of Neurosciences of the University of Lausanne (1996 – 1998). Pierre J. Magistretti is Professor of Physiology (since 1988) at the University of Lausanne Medical School. He has been Vice-Dean of the University of Lausanne Medical School from 1996 to 2000. Pierre Magistretti, is Director of the Brain Mind Institute at EPFL and Director of the Center for Psychiatric Neuroscience of the University of Lausanne and CHUV. He is also Director of the NCCR SYNAPSY "the synaptic bases of mental diseases". POSITIONS AND HONORS MAIN POSITION HELD • 1988-2004 Professor of Physiology, University of Lausanne Medical School • 1996-2000 Vice-Dean for Preclinical Departments, University of Lausanne Medical School • 2001-2004 Chairman, Department of Physiology, University of Lausanne Medical School • 2004-present Professor and Director, Center for Psychiatric Neuroscience, Department of Psychiatry, University of Lausanne Medical School and Hospitals (UNIL-CHUV) (Joint appointment with EPFL) • 2005-2008 Professor and Co-Director, Brain Mind Institute, Federal Institute of Technology (EPFL), Lausanne (Joint appointment with UNIL-CHUV) • 2007-present Chairman of the Scientific Advisory Board of Centre d’Imagerie Biomédicale (CIBM), an Imaging Consortium of the Universities, University Hospitals of Lausanne and Geneva and of Ecole Polytechnique Fédérale de Lausanne • 2008-present Professor and Director, Brain Mind Institute, Federal Institute of Technology (EPFL), Lausanne Joint appointment with UNIL-CHUV) • 2010-present Director, National Center for Competence in Research (NCCR) “The synaptic bases of mental diseases” of the Swiss National Science Foundation • 2010-present Secretary General, International Brain Research Organization (IBRO) MAIN HONORS AND AWARDS • 1997 Recipient of the Theodore-Ott Prize of the Swiss Academy of Medical Sciences • 2001 Elected Member of Academia Europaea • 2001 Elected Member of the Swiss Academy of Medical Sciences, ad personam • 2002 Recipient of the Emil Kraepelin Guest Professorship, Max Planck Institute für Psychiatry, Münich • 2006 Elected Professor at Collège de France, Paris, International Chair 2007-2008 • 2009 Goethe Award for Psychoanalytic Scholarship, Canadian Psychological Association • 2011 Camillo Golgi Medal Award, Golgi Fondation • 2011 Elected Member of the American College of NeuroPsychopharmacology (ACNP)