Publications associées à Iterative and incremental development

An Iterative Adaptive Dynamic Programming Approach for Macroscopic Fundamental Diagram-Based Perimeter Control and Route Guidance

Macroscopic fundamental diagrams (MFDs) have been widely adopted to model the traffic flow of large-scale urban networks. Coupling perimeter control and regional route guidance (PCRG) is a promising strategy to decrease congestion heterogeneity and reduce ...

Informs2024

Cyclic Peptides for Drug Development

Christian Heinis, Xinjian Ji, Alexander Lund Nielsen

Cyclic peptides are fascinating molecules abundantly found in nature and exploited as molecular format for drug development as well as other applications, ranging from research tools to food additives. Advances in peptide technologies made over many years ...

Wiley-VCH Verlag GmbH2024

Metamodel for Safety Risk Management of Medical Devices Based on ISO 14971

Mihai Adrian Ionescu, David Atienza Alonso

The integration of information technologies into medical systems has led to an increase in digitalization, which results in enormous possibilities, but also challenges in system development. The ever-growing complexity of modern medical devices (MD) requir ...

2023

Impact of substrate clogging on vertical connectivity

Giovanni De Cesare, Romain Maxime Dubuis, Robin Schroff

Connectivity between the hyporheic zone and the flow is essential for the development of benthos and the reproductive success of spawning fish. The infiltration of fine sediment leads to clogging of the riverbed, reducing porosity and vertical water exchan ...

2023

Surrogate modelling for seismic collapse risk assessment of steel moment resisting frames

Dimitrios Lignos, Andronikos Skiadopoulos, Nenad Bijelic

With the overall goal of reducing the numerical burden of uncertainty quantification involved in seismic risk assessments, this paper examines opportunities for assessment of seismic collapse capacity and risk using data-driven surrogates as a complement t ...

2023

Personalized Productive Engagement Recognition in Robot-Mediated Collaborative Learning

Barbara Bruno, Jauwairia Nasir

In this paper, we propose and compare personalized models for Productive Engagement (PE) recognition. PE is defined as the level of engagement that maximizes learning. Previously, in the context of robot-mediated collaborative learning, a framework of prod ...

2022

On the development of multi-physics tools for nuclear reactor analysis based on OpenFOAM (R): state of the art, lessons learned and perspectives

Carlo Fiorina

In the last two decades, the use of OpenFOAM as a multi-physics library for nuclear applications has grown from a sporadic use for exploratory studies to a widespread application for the analysis of innovative reactor concepts and highly complex problems. ...

ELSEVIER SCIENCE SA2022

An Accuracy-Driven Compression Methodology to Derive Efficient Codebook-Based CNNs

David Atienza Alonso, Giovanni Ansaloni, Miguel Peon Quiros, Flavio Ponzina

Codebook-based optimizations are a class of algorithmic-level transformations able to effectively reduce the computing and memory requirements of Convolutional Neural Networks (CNNs). This approach tightly limits the number of unique weights in each layer, ...

2022

Assessing Computational Thinking: Development and Validation of the Algorithmic Thinking Test for Adults

Olivier Lévêque, Cécile Hardebolle, Jessica Elke Dehler Zufferey, Marc Lafuente Martinez

This study describes the development and validation process of a computational thinking (CT) test for adults. The team designed a set of items and explored a subset of those through two qualitative pilots. Then, in order to provide validity evidence based ...

2022

Code Generation Approach Supporting Complex System Modeling based on Graph Pattern Matching

Dimitrios Kyritsis, Yan Yan, Jinzhi Lu

Code generation is an effective way to drive the complex system development in model-based systems engineering. Currently, different code generators are developed for different modeling languages to deal with the development of systems with multi-domain. T ...

ELSEVIER2022

Towards Beam-Beam Simulations for FCC-ee

Tatiana Pieloni, Xavier Buffat, Mike Seidel, Giovanni Iadarola, Péter Kicsiny

The FCC-ee (Future Circular Collider) lepton collider is currently the most favored next generation research infrastructure project at CERN, aimed at studying properties of standard model particles with the highest precision ever. The chosen parameters of ...

JACoW Publishing, Geneva, Switzerland2022

Spearheading future omics analyses using dyngen, a multi-modal simulator of single cells

Wouter Saelens

We present dyngen, a multi-modal simulation engine for studying dynamic cellular processes at single-cell resolution. dyngen is more flexible than current single-cell simulation engines, and allows better method development and benchmarking, thereby stimul ...

Nature Research2021

A Knowledge Management Approach Supporting Model-Based Systems Engineering

Dimitrios Kyritsis, Jinzhi Lu, Lei Feng

Model-based Systems Engineering (MBSE) is a noval approach to support complex system development by formalizing system artifacts and development using models. Though MBSE models provide a completely structural formalisms about system development for system ...

2021

Directed evolution of DNA-wrapped single-walled carbon nanotube complexes for optical sensing

Benjamin Paul Johanès Gabriel Lambert

Single-walled carbon nanotubes (SWCNTs) have garnered significant interest for their applications in optical biosensing. SWCNTs exhibit a sensitive and photostable fluorescence in the near-infrared (NIR) range, allowing for the continuous monitoring of tar ...

EPFL2021

A Coarse-mesh Methodology for the Analysis of One and Two-phase Nuclear Reactor Thermal-hydraulics in a Multi-physics Context

Stefan Radman

The analysis of nuclear reactors for performance and safety assessment benefits from the use of computational tools. In this context, this work aims at the development and application of a thermal-hydraulics methodology and related software that respond to ...

EPFL2021

Method Development towards Orthogonal Electrophile Delivery

Lingxi Wang

Redox signaling events mediated by reactive electrophilic species (RES) are key players in several cellular processes. However, the studies on RES have been challenging due to their high reactivity towards numerous nucleophilic groups present in the cells ...

EPFL2021

Increasing the relevance of science for practice and practice for science: Quantitative empirical insights

Claudia Rebeca Binder Signer, Livia Bianca Fritz, Ralph Hansmann

We present results of a survey conducted with researchers and practitioners involved in a Swiss National Research Programme on steering energy consumption. We analyse what motivates practitioners and researchers to engage in a collaborative research projec ...

2020

Iterative Design and Evaluation of a Tangible Robot-Assisted Handwriting Activity for Special Education

Pierre Dillenbourg, Thibault Lucien Christian Asselborn, Ayberk Özgür, Arzu Güneysu Özgür, Barbara Bruno, Wafa Monia Benkaouar Johal, Elmira Yadollahi

In this article we investigate the role of interactive haptic-enabled tangible robots in supporting the learning of cursive letter writing for children with attention and visuomotor coordination issues. We focus on the two principal aspects of handwriting ...

2020

On Convergence-Diagnostic based Step Sizes for Stochastic Gradient Descent

Nicolas Henri Bernard Flammarion, Scott William Pesme, Aymeric Daphnis Kévin Dieuleveut

Constant step-size Stochastic Gradient Descent exhibits two phases: a transient phase during which iterates make fast progress towards the optimum, followed by a stationary phase during which iterates oscillate around the optimal point. In this paper, we s ...

2020

Challenges for biophysical modeling of microstructure

Ileana Ozana Jelescu

The biophysical modeling efforts in diffusion MRI have grown considerably over the past 25 years. In this review, we dwell on the various challenges along the journey of bringing a biophysical model from initial design to clinical implementation, identifyi ...

2020