Publications associées à Bêta-bloquant

Cardiovascular response to closed-loop intraneural stimulation of the right vagus nerve: a proof-of-concept study

Vagus nerve stimulation (VNS) is an FDA-approved technique for the neuromodulation of the autonomic nervous system. There are many therapeutic applications where VNS could be used as a therapy, such as cardiovascular diseases, epilepsy, depression, and inf ...

IEEE2023

Effect of the structural modification of Candesartan with Zinc on hypertension and left ventricular hypertrophy

Nikolaos Stergiopoulos, Augusto Martins Lima, Valeria Romina Martinez

Hypertension is the most common cause of left ventricular hypertrophy, contributing to heart failure progression. Candesartan (Cand) is an angiotensin receptor antagonist widely used for hypertension treatment. Structural modifications were previously perf ...

ELSEVIER2023

Effect of minor amounts of beta-calcium pyrophosphate and hydroxyapatite on the physico-chemical properties and osteoclastic resorption of beta-tricalcium phosphate cylinders

Paul Bowen, Gabrielle Anne Laguisma Sblendorio

beta-Tricalcium Phosphate (beta-TCP), one of the most used bone graft substitutes, may contain up to 5 wt% foreign phase according to standards. Typical foreign phases include beta-calcium pyrophosphate (beta-CPP) and hydroxyapatite (HA). Currently, the ef ...

KEAI PUBLISHING LTD2022

Mitochondrial Creatine Kinase Attenuates Pathologic Remodeling in Heart Failure

Yi Zhang, Annina Stuber, Ashish Gupta

BACKGROUND: Abnormalities in cardiac energy metabolism occur in heart failure (HF) and contribute to contractile dysfunction, but their role, if any, in HF-related pathologic remodeling is much less established. CK (creatine kinase), the primary muscle ene ...

LIPPINCOTT WILLIAMS & WILKINS2022

The role of nicotinamide riboside metabolism in pancreatic beta cells

Angélique Satoko Cercillieux

Pancreatic beta cells play a major role in the regulation of glucose homeostasis by secreting insulin in response to elevated blood glucose levels. A gradual deterioration of functional beta cell mass and the chronic elevation of blood glucose levels are c ...

EPFL2022

Manufacturing, installation, commissioning, and first results with the 3D low-temperature co-fired ceramic high-frequency magnetic sensors on the Tokamak a Configuration Variable

Duccio Testa

Innovative high-frequency magnetic sensors have been designed and manufactured in-house for installation on the Tokamak a Configuration Variable (TCV), which are now routinely operational during the TCV experimental campaigns. These sensors combine the Low ...

2020

Heart Rate Variability Triangular Index as a Predictor of Cardiovascular Mortality in Patients With Atrial Fibrillation

Jean-Marc Vesin, Vincent Schlageter

Background Impaired heart rate variability (HRV) is associated with increased mortality in sinus rhythm. However, HRV has not been systematically assessed in patients with atrial fibrillation (AF). We hypothesized that parameters of HRV may be predictive o ...

2020

LTCC magnetic sensors at EPFL and TCV: Lessons learnt for ITER

Duccio Testa, Xavier Llobet, Pierre Lavanchy, Matthieu Toussaint, Ugo Siravo, Frédéric Dolizy, Jonathan Bryan Lister, Thomas Maeder, Steve Couturier, Philippe Marmillod, Severino Antonioni, Caroline Jacq, Christian Moura, Blaise Marlétaz, Aylwin Iantchenko, Lorenzo Stipani, Adrien Aymeric Thibault Corne, Matthias Garcin

Innovative 3D high-frequency magnetic sensors have been designed and manufactured in-house for installation on the Tokamak a Configuration Variable (TCV), and are currently routinely operational. These sensors combine the Low Temperature Co-fired Ceramic ( ...

2019

A method for preparing phfs-like tau aggregates

Hilal Lashuel, Nadine Aït Bouziad

The invention relates to a method for preparing PHFs-like Tau aggregates and to a method for identifying compounds that are inhibitors of Tau protein aggregation, blockers of Tau seeding and propagation, and imaging agents that specifically bind PHF. ...

2019

Cortical reactive balance responses to unexpected slippages while walking: a pilot study

Silvestro Micera, Daniela De Venuto

Understanding how the human brain cortex behaves when the dynamical balance is unexpectedly challenged can be useful to enable fall prevention strategies during daily activities. In this respect, we designed and tested a novel methodological approach to ea ...

IEEE2019

The matricellular protein CYR61 interferes with normal pancreatic islets architecture and promotes pancreatic neuroendocrine tumor progression

Jelena Zaric, Yu-Ting Huang

The significance of matricellular proteins during development and cancer progression is widely recognized. However, how these proteins actively contribute to physiological development and pathological cancer progression is only partially elucidated. In thi ...

Impact Journals Llc2016

Antihypertensive drugs metabolism: an update to pharmacokinetic profiles and computational approaches

Vassily Hatzimanikatis, Ljubisa Miskovic, Aikaterini Zisaki

Drug discovery and development is a high-risk enterprise that requires significant investments in capital, time and scientific expertise. The studies of xenobiotic metabolism remain as one of the main topics in the research and development of drugs, cosmet ...

Bentham Science Publishers2015

Right insular damage decreases heartbeat awareness and alters cardio-visual effects on bodily self-consciousness

Olaf Blanke, Bruno Herbelin, Roberta Ronchi, Javier Bello Ruiz, Marta Lukowska

Recent evidence suggests that multisensory integration of bodily signals involving exteroceptive or interoceptive information modulates bodily aspects of self-consciousness such as self-identification and self-location. In the so-called full body illusion ...

Pergamon-Elsevier Science Ltd2015

Type 5 adenylyl cyclase disruption leads to enhanced exercise performance

Johan Auwerx, Laurent Mouchiroud, Richardus Houtkooper, Jie Zhang

The most important physiological mechanism mediating enhanced exercise performance is increased sympathetic, beta adrenergic receptor (beta-AR), and adenylyl cyclase (AC) activity. This is the first report of decreased AC activity mediating increased exerc ...

Wiley-Blackwell2015

Role of the renin-angiotensin system on abdominal aortic aneurysms

Nikolaos Stergiopoulos, Bram Trachet

BackgroundAbdominal aortic aneurysm (AAA) is a complex degenerative disease, which leads to morbidity and mortality in a large portion of the elderly population. Current treatment options for AAA are quite limited as there is no proven indication for pharm ...

Wiley-Blackwell2013

Transgenic expression of beta 1 antibody in brain neurons impairs age-dependent amyloid deposition in APP23 mice

Maurizio Molinari, Paolo Paganetti

Heterologous expression of the functional amyloid beta (A beta) antibody beta 1 in the central nervous system was engineered to maximize antibody exposure in the brain and assess the effects on A beta production and accumulation in these conditions. A sing ...

Elsevier Science Inc2013

Atrial septal pacing for the termination of atrial fibrillation: study in a biophysical model of human atria

Jean-Marc Vesin, Laurent Renaud Uldry, Lukas Kappenberger

Aims While successful termination by pacing of organized atrial tachycardias has been observed in patients, single site rapid pacing has not yet led to conclusive results for the termination of atrial fibrillation (AF). The purpose of this study was to eva ...

Oxford Univ Press2012

Specific Silencing of the REST Target Genes in Insulin-Secreting Cells Uncovers Their Participation in Beta Cell Survival

Emilie Gesina

The absence of the transcriptional repressor RE-1 Silencing Transcription Factor (REST) in insulin-secreting beta cells is a major cue for the specific expression of a large number of genes. These REST target genes were largely ascribed to a function of ne ...

Public Library of Science2012

Optimizing Local Capture of Atrial Fibrillation by Rapid Pacing: Study of the Influence of Tissue Dynamics

Jean-Marc Vesin, Vincent Jacquemet, Laurent Renaud Uldry, Lukas Kappenberger

While successful termination by pacing of organized atrial tachycardias has been observed in patients, rapid pacing of AF can induce a local capture of the atrial tissue but in general no termination. The purpose of this study was to perform a systematic e ...

Springer Verlag2010

Identification of genetic insulator elements to increase the safety of viral gene therapy vectors

Armelle Gaussin

Haematopoeitic system diseases, both acquired and inherited, can be currently cured by allogeneic haematopoietic stem cell transplantation. This treatment provides highly successful immune function recovery for patients receiving grafts of HLA-compatible d ...

EPFL2010