Dégénérescence lobaire frontotemporale

Applied sciences
Health sciences
Neurologie
Maladie neurodégénérative

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Publications associées (28)

Astrocytes: New Targets for the Treatment of Neurodegenerative Diseases

Pierre Magistretti, Sylvain Eric Lengacher, Charles Léonard Finsterwald

The causes of neurodegenerative disorders are multiple, and for most of them a mechanistic understanding is still lacking. However, neurodegenerative diseases such as Alzheimer disease (AD), amyotrophic lateral sclerosis (ALS) and Parkinson disease (PD) al ...

Bentham Science Publishers2015

Perineuronal net digestion with chondroitinase restores memory in mice with tau pathology

Patrick Aebischer, Bernard Schneider

Alzheimer's disease is the most prevalent tauopathy and cause of dementia. We investigate the hypothesis that reactivation of plasticity can restore function in the presence of neuronal damage resulting from tauopathy. We investigated two models with tau h ...

2015

Cortical Interneuron Loss and Symptom Heterogeneity in Huntington Disease

Doris Chau Voo Thu

Objective: The cellular basis of variable symptoms in Huntington disease (HD) is unclear. One important possibility is that degeneration of the interneurons in the cerebral cortex, which play a critical role in modulating cortical output to the basal gangl ...

Wiley-Blackwell2014

Evolution of source EEG synchronization in early Alzheimer's disease

Reto Meuli, Alireza Khadivi, Cristian Carmeli

Alzheimer's disease (AD) disrupts functional connectivity in distributed cortical networks. We analyzed changes in the S-estimator, a measure of multivariate intraregional synchronization, in electroencephalogram (EEG) source space in 15 mild AD patients v ...

Elsevier2013

Focal expression of adeno-associated viral-mutant tau induces widespread impairment in an APP mouse model

Patrick Aebischer, Jean-Charles Bensadoun, Bernard Schneider

Adeno-associated virus serotype 6 (AAV6) viral vectors encoding mutant and normal tau were used to produce focal tau pathology. Two mutant forms of tau were used; the P301S tau mutation is associated with neurofibrillary tangle formation in humans, and the ...

Elsevier Science Inc2013

Co-pathological states of tau proteins in a 3D micropatterned neural cell culture

Philippe Renaud, Robert Meissner, Anja Kunze, Serena Brando

In vitro studies of Alzheimer’s disease are based on homogenously seeded neural cells. These studies reveal molecular pathway mechanism related to neurite degeneration, but they cannot analyze interactions between diseased and healthy cells. Furthermore, t ...

2011

Transmission and spreading of tauopathy in transgenic mouse brain

Tristan Bolmont

Hyperphosphorylated tau makes up the filamentous intracellular inclusions of several neurodegenerative diseases, including Alzheimer's disease(1). In the disease process, neuronal tau inclusions first appear in the transentorhinal cortex from where they se ...

Nature Publishing Group2009

Abnormal Localization of Leucine-Rich Repeat Kinase 2 to the Endosomal-Lysosomal Compartment in Lewy Body Disease

Darren Moore

Missense mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common causes of both familial and sporadic forms of Parkinson disease and are also associated with diverse pathological alterations. The mechanisms whereby LRRK2 mutations ca ...

2009

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