Publications associées à Sucrette

Structure-function analysis of the cyclic β-1,2-glucan synthase from Agrobacterium tumefaciens

Henning Paul-Julius Stahlberg, Dongchun Ni

The synthesis of complex sugars is a key aspect of microbial biology. Cyclic beta-1,2-glucan (C beta G) is a circular polysaccharide critical for host interactions of many bacteria, including major pathogens of humans (Brucella) and plants (Agrobacterium). ...

Nature Portfolio2024

Development of Sustainable Carbohydrate-Based Solvents by Acetal Functionalisation of Biomass

Anastasiia Komarova

Organic solvents are ubiquitous in industrial and domestic applications from the production of pharmaceuticals to household consumer products. The negative impact of most traditional solvents, especially aprotic types, on the environment, health, and safet ...

EPFL2024

cgNA+: A sequence-dependent coarse-grain model of double-stranded nucleic acids

Rahul Sharma

DNA mechanics plays a crucial role in many biological processes, including nucleosome positioning and protein-DNA interactions. It is believed that nature employs epigenetic modifications in DNA to further regulate gene expression. Moreover, double-strande ...

EPFL2023

Developing structure-oriented models for enzymatic hydrolysis of lignocellulosic biomass

Jessica Charlène Rohrbach

With the unsustainable use of fossil fuels increasing strains on human institutions and ecosystems, the development of a renewable energy alternative is of paramount importance. Second generation biorefineries, based on the production of fuels and chemical ...

EPFL2021

Production and characterization of stabilized lignin

Masoud Talebi Amiri

Lignocellulosic biomass is a sustainable source of renewable carbon, and it is the most abundant form of terrestrial biomass. The three main constituents of lignocellulosic biomass are cellulose, hemicellulose, and lignin. The monomers from these biopolyme ...

EPFL2019

Overlapping spatial clusters of sugar-sweetened beverage intake and body mass index in Geneva state, Switzerland

Stéphane Joost, Idris Guessous, David Nicolas De Ridder, Beatrice Bacchilega

Background: Obesity and obesity-related diseases represent a major public health concern. Recently, studies have substantiated the role of sugar-sweetened beverages (SSBs) consumption in the development of these diseases.The fine identification of populati ...

Springer2019

Catalytic Upgrading of Biomass-Derived Carboxylic Acids to Fuels and Chemicals

Jher Hau Yeap

Our reliance on fossil fuels, which is unsustainable due to dwindling reserves, has led to various environmental issues. Lignocellulosic biomass could serve as a renewable source of carbon and energy for the production of fuels and chemicals. While several ...

EPFL2019

Improved Sugars Release from Chili Post-harvest Residues by Dilute Acid Assisted Lime Pretreatment

Edgard Gnansounou

Lignocellulosic biomass seems promising renewable feedstocks for the production of biofuels and other value-added products. It is composed of cellulose, hemicelluloses and lignin, which are connected by several intra-and inter-polymer linkages. For effecti ...

2018

Detecting overlapping spatial clusters of high sugar-sweetened beverage intake and high body mass index in a general population: a cross-sectional study

Stéphane Joost, Idris Guessous, David Nicolas De Ridder, Beatrice Bacchilega

Background: Evidence suggests that sugar-sweetened beverage (SSB) intake frequency is positively associated with the risk of obesity and diabetes. We aimed to identify populations and areas in high need for interventions to reduce SSB consumption using a f ...

2018

Physiological Adaptations to Sugar Intake: New Paradigms from Drosophila melanogaster

Bruno Lemaitre, Wen Bin Chng

Sugars are important energy sources, but high sugar intake poses a metabolic challenge and leads to diseases. Drosophila melanogaster is a generalist fruit breeder that encounters high levels of dietary sugars in its natural habitat. Consequently, Drosophi ...

Elsevier2017

Complex event recognition through wearable sensors

Jean-Eudes Marie Ranvier

Complex events are instrumental in understanding advanced behaviours and properties of a system. They can represent more meaningful events as compared to simple events. In this thesis we propose to use wearable sensor signals to detect complex events. Thes ...

EPFL2017

A mild biomass pretreatment using gamma-valerolactone for concentrated sugar production

Jeremy Luterbacher, Ydna Marie Questell-Santiago, Li Shuai

Here we report that gamma-valerolactone (GVL), a biomass-derived solvent, can be used to facilitate the mild pretreatment of lignocellulosic biomass. An 80% GVL, 20% water solvent system was used to pretreat hardwood at the mild temperature of 120 degrees ...

Royal Society of Chemistry2016

Sustainability assessment of succinic acid production technologies from biomass using metabolic engineering

Vassily Hatzimanikatis, Meriç Ataman, Merten Morales, Konrad Hungerbühler

Over the past few years, bio-succinic acid from renewable resources has gained increasing attention as a potential bio-derived platform chemical for the detergent/surfactant, ion chelator, food and pharmaceutical markets. Until now, much research was under ...

Royal Soc Chemistry2016

Dissecting the Effects of Concentrated Carbohydrate Solutions on Protein Diffusion, Hydration, and Internal Dynamics

Matteo Dal Peraro, Enrico Spiga, Luciano Andres Abriata, Francesco Piazza

We present herein a thorough description of the effects of high glucose concentrations on the diffusion, hydration and internal dynamics of ubiquitin, as predicted from extensive molecular dynamics simulations on several systems described at fully atomisti ...

Amer Chemical Soc2014

Kinetic models in industrial biotechnology - Improving cell factory performance

Vassily Hatzimanikatis, Jens Nielsen

An increasing number of industrial bioprocesses capitalize on living cells by using them as cell factories that convert sugars into chemicals. These processes range from the production of bulk chemicals in yeasts and bacteria to the synthesis of therapeuti ...

Academic Press Inc Elsevier Science2014

Sustainability assessment of lignocellulosic biorefineries under uncertainty

Juan David Villegas Gomez

Biorefinery concepts refer to the integrated production of food, fuel, power, commodity chemicals, and polymers from biomass, mimicking the structure of a fossil-based refinery. The use of lignocellulosic biomass as feedstock for biorefineries has been pro ...

EPFL2014

COUP-TFII Controls Mouse Pancreatic beta-Cell Mass through GLP-1-beta-Catenin Signaling Pathways

Anne Grapin-Botton

Background: The control of the functional pancreatic beta-cell mass serves the key homeostatic function of releasing the right amount of insulin to keep blood sugar in the normal range. It is not fully understood though how beta-cell mass is determined. ...

2012

Microelectrode-based dielectric spectroscopy of glucose effect on erythrocytes

Philippe Renaud, Ludovica Colella

The dielectric response of biconcave erythrocytes exposed to D-glucose and I.-glucose has been investigated using a double array of planar interdigitated microelectrodes on a glass microchip. Erythrocytes are analyzed under physiological conditions suspend ...

2012

The spirocyclopropyl moiety as a methyl surrogate in the structure of L-fucosidase and L-rhamnosidase inhibitors

Pierre Vogel, Claudia Bello

Nitrogen-in-the-ring analogues of L-fucose and L-rhamnose were prepared, which feature a spirocyclopropyl moiety in place of the methyl group of the natural sugar. The synthetic route involved a titanium-mediated aminocyclopropanation of a glycononitrile a ...

2009

SYNTHESIS AND PARAMETER OPTIMIZATION OF A COMBINED SUGAR AND ETHANOL PRODUCTION PROCESS INTEGRATED WITH A CHP SYSTEM Part 2: Maximization of total site net power

François Maréchal, Adriano Viana Ensinas

The combined sugar and ethanol production process from sugar cane is a paradigmatic application for energy integration strategies because of the high number of hot and cold streams involved, the external hot utility requirement at two temperature levels fo ...

2009