Publications associées à Restenosis

Compliance-matching vascular grafts with personalization potential

Aortic diseases are characterized by dire prognosis and inadequate diagnosis, owing to their insidious yet lethal nature. Aortopathies, namely aortic aneurysms and dissections, along with certain congenital diseases, might necessitate surgical replacement ...

EPFL2023

Targeted capillary photothrombosis via multiphoton excitation of Rose Bengal

Paul James Marchand

Microvascular stalling, the process occurring when a capillary temporarily loses perfusion, has gained increasing interest in recent years through its demonstrated presence in various neuropathologies. Studying the impact of such stalls on the surrounding ...

2023

Macrophage NCOR1 Deficiency Ameliorates Myocardial Infarction and Neointimal Hyperplasia in Mice

Johan Auwerx, Hongwei Zhu, Yuan Liu, Yan Liu, Shuai Shao

Background NCOR1 (nuclear receptor corepressor 1) is an essential coregulator of gene transcription. It has been shown that NCOR1 in macrophages plays important roles in metabolic regulation. However, the function of macrophage NCOR1 in response to myocard ...

2020

Metabolic fingerprints discriminating severity of acute ischemia using in vivo high-field H-1 magnetic resonance spectroscopy

Mario Gaetano Lepore, Hongxia Lei, Lara Buscemi Estefanell

Despite the improving imaging techniques, it remains challenging to produce magnetic resonance (MR) imaging fingerprints depicting severity of acute ischemia. The aim of this study was to evaluate the potential of the overall high-field H-1 MR Spectroscopy ...

Wiley-Blackwell2020

Neurovascular stent artifacts in 3D-TOF and 3D-PCMRI: Influence of stent design on flow measurement

Mohamed Farhat, Pierre Bouillot, Hasan Yilmaz

Purpose: The morphological and hemodynamic evaluations of neurovascular diseases treated with stents would benefit from noninvasive imaging techniques such as 3D time-of-flight MRI (3D-TOF) and 3D phase contrast MRI (3D-PCMRI). For this purpose, a comprehe ...

WILEY2019

Computational study of the risk of restenosis in coronary bypasses

Alfio Quarteroni, Christian Vergara

Coronary artery disease, caused by the buildup of atherosclerotic plaques in the coronary vessel wall, is one of the leading causes of death in the world. For high-risk patients, coronary artery bypass graft is the preferred treatment. Despite overall exce ...

Springer Heidelberg2017

A Monolithic Approach to Fluid–Composite Structure Interaction

Simone Deparis, Davide Forti, Annalisa Quaini

We study a nonlinear fluid–structure interaction (FSI) problem between an incompressible, viscous fluid and a composite elastic structure consisting of two layers: a thin layer (membrane) in direct contact with the fluid, and a thick layer (3D linearly ela ...

Springer Verlag2017

Computational comparison of aortic root stresses in presence of stentless and stented aortic valve bio-prostheses

Alfio Quarteroni, Christian Vergara, Elena Faggiano

We provide a computational comparison of the performance of stentless and stented aortic prostheses, in terms of aortic root displacements and internal stresses. To this aim, we consider three real patients; for each of them, we draw the two prostheses con ...

Taylor & Francis Ltd2017

Particle Imaging Velocimetry Evaluation of Intracranial Stents in Sidewall Aneurysm: Hemodynamic Transition Related to the Stent Design

Mohamed Farhat, Pierre Bouillot

We investigated the flow modifications induced by a large panel of commercial-off-the-shelf (COTS) intracranial stents in an idealized sidewall intracranial aneurysm (IA). Flow velocities in IA silicone model were assessed with and without stent implantati ...

Public Library of Science2014

Self-Navigation with Compressed Sensing for 2D translational Motion Correction in Free-Breathing Coronary MRI: a Feasibility Study

Yves Wiaux, Gilles Puy, Ruud van Heeswijk, Davide Piccini, Gabriele Vincenzo Bonanno

Purpose Respiratory motion correction remains a challenge in coronary magnetic resonance imaging (MRI) and current techniques, such as navigator gating, suffer from sub-optimal scan efficiency and ease-of-use. To overcome these limitations, an image-based ...

Public Library of Science2014

Flow diversion treatment: intra-aneurismal blood flow velocity and WSS reduction are parameters to predict aneurysm thrombosis

Philippe Reymond, Luca Augsburger, Daniel Ruefenacht

To evaluate the haemodynamic changes induced by flow diversion treatment in cerebral aneurysms, resulting in thrombosis or persisting aneurysm patency over time. Eight patients with aneurysms at the para-ophthalmic segment of the internal carotid artery we ...

Springer Verlag2012

Controlled release nanoparticle-embedded coatings reduce the tissue reaction to neuroprostheses

Philippe Renaud, André Mercanzini, Philippe Colin, Jeffrey Alan Hubbell, Jean-Charles Bensadoun, Sai Reddy

Controlled release coatings were developed for neuroprostheses with the aim of combating the tissue reaction following implantation in the brain. The coatings consist of poly(propylene sulfide) drug-eluting nanoparticles embedded in a poly(ethylene oxide) ...

Elsevier2010

Nanostructured ceramic coating for deformable medical implants such as stents

Arnaud Tourvieille de Labrouhe

Coronary artery disease is one of the main causes of death in western countries. The standard of care has become the implantation of a coronary stent, i.e. a small metal-mesh tube reopening the lumen of the artery and maintaining the blood flow to the hear ...

EPFL2009

Nanostructured Ceramic Coatings for Drug Delivery

Heinrich Hofmann, Laurent-Dominique Piveteau, Arnaud Tourvieille de Labrouhe, Karin Dittmar

Drug eluting stents (DES) have been successfully implemented in clinical practice in the treatment against coronary artery disease. Compared to the implantation of bare metal stents, restenosis rates decreased significantly after stenting of DES into coron ...

Materials Research Society, 506 Keystone Drive, Warrendale, Pa 15086-7573 Usa2009

Nanostructured titania coatings for drug-eluting medical implants

Karin Dittmar

Medical implants delivering drugs are used to ensure efficient medication at body sites, at which the conventional administration of drugs is insufficient. The application of drug-delivery coatings is a beneficial concept for implants exposed to mechanical ...

EPFL2009

VR simulation of interventional radiology and microsurgery

Fei Wang

Currently trainees typically learn surgery techniques directly on mocks, animals or cadavers. For safety, cost and ethics reasons, one cannot try all possible strategies to achieve efficient learning. Virtual Reality (VR) based surgery training systems int ...

EPFL2009

A Real-Time Simulator for Interventional Radiology

Hannes Bleuler, Lindo Robert Duratti, Evren Samur, Fei Wang

Interventional radiologists manipulate guidewires and catheters and steer stents through the patient’s vascular system under X-ray imaging for treatment of vascular diseases. The complexity of these procedures makes trainingmandatory in order to master han ...

2008

Reproducibility of haemodynamical simulations in a subject-specific stented aneurysm model - A report on the Virtual Intracranial Stenting Challenge 2007

Philippe Reymond, Luca Augsburger, Daniel Ruefenacht

This paper presents the results of the Virtual Intracranial Stenting Challenge (VISC) 2007, an international initiative whose aim was to establish the reproducibility of state-of-the-art haemodynamical simulation techniques in subject-specific stented mode ...

2008

Modélisation mécanique de fils pour la simulation chirurgicale

Lindo Robert Duratti

Minimally Invasive Surgery (MIS) represents one of the major progresses in surgery in the last decade. In general, it is based on the application of small body-cuts through which instruments are inserted into the patient's body allowing the surgeon to carr ...

EPFL2008

Haptic instrumentation for an interventional radiology simulator

Dejan Ilic

Low trauma, reduced costs and fast recovery are only a few factors why minimally invasive surgery (MIS) is taking over classical surgical methods. Interventional Radiology (IR) is a minimally invasive procedure where thin tubular instruments are steered th ...

EPFL2005