Publications associées à Human genetic enhancement

Identifying genetic and dietary modulators of metabolic disorders using systems genetics

Long-term consumption of lipid-rich foods can contribute to common metabolic diseases and systemic low-grade inflammation. However, dietary responses and the development of non-communicable diseases are shaped by genetic factors and gene-by-environment int ...

EPFL2023

The present and future of neural interfaces

Marcello Ienca

The 2020's decade will likely witness an unprecedented development and deployment of neurotechnologies for human rehabilitation, personalized use, and cognitive or other enhancement. New materials and algorithms are already enabling active brain monitoring ...

FRONTIERS MEDIA SA2022

Optogenetic control of Neisseria meningitidis Cas9 genome editing using an engineered, light-switchable anti-CRISPR protein

Bruno Emanuel Ferreira De Sousa Correia, Zander Harteveld, Julius Valten Upmeier Zu Belzen

Optogenetic control of CRISPR-Cas9 systems has significantly improved our ability to perform genome perturbations in living cells with high precision in time and space. As new Cas orthologues with advantageous properties are rapidly being discovered and en ...

2021

Efficient viral transduction in mouse inner ear hair cells with utricle injection and AAV9-PHP.B

Bernard Schneider, Paola Andrea Solanes Vega

Viral delivery of exogenous coding sequences into the inner ear has the potential for therapeutic benefit for patients suffering genetic or acquired hearing loss. To devise improved strategies for viral delivery, we investigated two injection techniques, r ...

2020

Genetic-optimised aperiodic code for distributed optical fibre sensors

Luc Thévenaz, Marcelo Alfonso Soto Hernandez, Zhisheng Yang, Simon Adrien Zaslawski, Sheng Wang, Jian Wu

Distributed optical fibre sensors deliver a map of a physical quantity along an optical fibre, providing a unique solution for health monitoring of targeted structures. Considerable developments over recent years have pushed conventional distributed sensor ...

Nature Research2020

Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism

Johan Auwerx, Martin Rainer Wohlwend

Obesity and type 2 diabetes (T2D) are metabolic disorders influenced by lifestyle and genetic factors that are characterized by insulin resistance in skeletal muscle, a prominent site of glucose disposal. Numerous genetic variants have been associated with ...

Nature Research2020

Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss

Bernard Schneider, Paola Andrea Solanes Vega, Sofia Carmen Suzanne Spataro

Since most dominant human mutations are single nucleotide substitutions(1,2), we explored gene editing strategies to disrupt dominant mutations efficiently and selectively without affecting wild-type alleles. However, single nucleotide discrimination can b ...

NATURE PUBLISHING GROUP2019

Analysis of Inherited Optic Neuropathies

Background Inherited optic neuropathies (IONs) cover a spectrum of clinically and genetically heterogenic conditions. Genetic evaluation of patients with IONs may enable their better clinico-diagnostic assessment and management of the disease. The aim of t ...

2019

Overload blunts baroreflex only in overreached athletes

Jean-Marc Vesin, Grégoire Millet, Sasan Yazdani, Masih Nilchian

Heart rate variability (HRV) is commonly used to diagnose overreaching and monitor athletes’ responses to training. Baroreflex sensitivity (BRS) is modified by changes in training load and might be another means to detect overreaching. The goal of this stu ...

2018

Engineered anti-CRISPR proteins for optogenetic control of CRISPR-Cas9

Bruno Emanuel Ferreira De Sousa Correia, Zander Harteveld

Anti-CRISPR proteins are powerful tools for CRISPR-Cas9 regulation; the ability to precisely modulate their activity could facilitate spatiotemporally confined genome perturbations and uncover fundamental aspects of CRISPR biology. We engineered optogeneti ...

NATURE PUBLISHING GROUP2018

Tidal Interactions and Mergers in Intermediate-redshift EDisCS Clusters

Pascale Jablonka

We study the fraction of tidal interactions and mergers (TIMs) with well-identified observability timescales (f(TIM)) in group, cluster, and accompanying field galaxies and its dependence on redshift (z), cluster velocity dispersion (sigma), and environmen ...

IOP PUBLISHING LTD2018

Image and video denoising for distributed optical fibre sensors

Luc Thévenaz, Marcelo Alfonso Soto Hernandez

A technique based on a multi-dimensional signal processing approach is here described for performance enhancement of distributed optical fibre sensors. In particular, the main features of linear and nonlinear image denoising techniques are described for si ...

Ieee2017

AAV based gene therapy for rare diseases : targeting astrocytes for functional recovery in Amyotrophic Lateral Sclerosis

Cylia Cloé Rochat

Of the seven thousand diseases that are described as rare, 80% of them have an identified genetic cause. With this in the mind, the development of technologies, such as gene therapy, to address the genetic factors involved in these pathologies, might be a ...

EPFL2017

A transparent silk-fibroin-based triboelectric microgenerator for airflow energy harvesting

Jürgen Brugger, Xiao Sheng Zhang, Ya Wang, Yinben Guo

We present a new transparent high-performance triboelectric microgenerator (TEMG) based on an emerging material, silk fibroin. Silk fibroin has a strong ability to lose electrons and occupies a top-level positive position in the triboelectric series. It th ...

IEEE Xplore2017

Remarkable enhancement of bacterial inactivation in wastewater through promotion of solar photo-Fenton at near-neutral pH by natural organic acids

César Pulgarin, Stefanos Giannakis, Paola Villegas Guzman

In this work, the near-neutral photo-Fenton process, as a means of wastewater disinfection, was enhanced by the addition of Organic Acids (OAs), namely citric, ascorbic, tartaric and caffeic acid. The addition of OAs exhibited significant bacterial inactiv ...

Elsevier2017

Cell-mediated delivery of synthetic nano- and microparticles funding

Harm-Anton Klok, Maxime Ayer

Cell mediated delivery of synthetic nano- and microparticle based drug carriers is a very promising strategy to enhance control over the distribution of drugs and improve targeting. This article will present an overview of work, which has been done to expl ...

2017

Collection, access and use of human genetic information for precision medicines: Risk governance considerations

Marie-Valentine Renée Agnès Florin

Gene technologies and their application by industry are developing rapidly, particularly in the US and in China. Yet, governance of the field of genomic for precision medicine is developing more slowly and needs to catch up. The rapid developments in scien ...

International Risk Governance Council (IRGC)2016

Identification and Characterization of Tyrosine Kinase Nonreceptor 2 Mutations in Leukemia through Integration of Kinase Inhibitor Screening and Genomic Analysis

Oliver Hantschel, Sina Maren Reckel

The amount of genomic information about leukemia cells currently far exceeds our overall understanding of the precise genetic events that ultimately drive disease development and progression. Effective implementation of personalized medicine will require t ...

American Association for Cancer Research2016

Cognetics: Robotic Interfaces for the Conscious Mind

Olaf Blanke, Giulio Rognini

Cognetics joins the cognitive neuroscience of bodily awareness with robotics to study, control, and enhance perception, cognition, and consciousness. We highlight robot-controlled bodily perception, conscious states, and social interactions and sketch how ...

Elsevier2016

Intensifying the response of distributed optical fibre sensors using 2D and 3D image restoration

Luc Thévenaz, Marcelo Alfonso Soto Hernandez

Distributed optical fibre sensors possess the unique capability of measuring the spatial and temporal map of environmental quantities that can be of great interest for several field applications. Although existing methods for performance enhancement have e ...

Nature Publishing Group2016