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Patrick Aebischer

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Publications associées (172)

Genetic engineering of cell lines using lentiviral vectors to achieve antibody secretion following encapsulated implantation

Patrick Aebischer, Bernard Schneider, Marc Moniatte, Aurélien Lathuilière

The controlled delivery of antibodies by immunoisolated bioimplants containing genetically engineered cells is an attractive and safe approach for chronic treatments. To reach therapeutic antibody levels there is a need to generate renewable cell lines, wh ...

Elsevier2014

Focal expression of adeno-associated viral-mutant tau induces widespread impairment in an APP mouse model

Patrick Aebischer, Jean-Charles Bensadoun, Bernard Schneider

Adeno-associated virus serotype 6 (AAV6) viral vectors encoding mutant and normal tau were used to produce focal tau pathology. Two mutant forms of tau were used; the P301S tau mutation is associated with neurofibrillary tangle formation in humans, and the ...

Elsevier Science Inc2013

Synergistic Effects of GDNF and VEGF on Lifespan and Disease Progression in a Familial ALS Rat Model

Patrick Aebischer, Michaël Meyer

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motor neurons in the brain and spinal cord. We have recently shown that human mesenchymal stem cells (hMSCs) modified to release glial cell li ...

Nature Publishing Group2013

Direct and Retrograde Transduction of Nigral Neurons with AAV6, 8, and 9 and Intraneuronal Persistence of Viral Particles

Patrick Aebischer, Bernard Schneider

Recombinant adeno-associated viral (AAV) vectors of serotypes 6, 8, and 9 were characterized as tools for gene delivery to dopaminergic neurons in the substantia nigra for future gene therapeutic applications in Parkinson's disease. While vectors of all th ...

Mary Ann Liebert2013

An in vivo ultrahigh field 14.1 T (1) H-MRS study on 6-OHDA and α-synuclein-based rat models of Parkinson's disease: GABA as an early disease marker

Patrick Aebischer, Bernard Schneider, Rolf Gruetter, Meret Gaugler, Philippe Guillaume Coune, Mélanie Craveiro

The detection of Parkinson's disease (PD) in its preclinical stages prior to outright neurodegeneration is essential to the development of neuroprotective therapies and could reduce the number of misdiagnosed patients. However, early diagnosis is currently ...

Wiley-Blackwell2013

Astrocyte–neuron co-culture on microchips based on the model of SOD mutation to mimic ALS

Patrick Aebischer, Philippe Renaud, Sylvain Eric Lengacher, Pierre Magistretti, Anja Kunze, Elisabeth Anne Dirren

Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease. ALS is believed to be a non-cell autonomous condition, as other cell types, including astrocytes, have been implicated in disease pathogenesis. Hence, to facilitate the developmen ...

Royal Soc Chemistry2013

Nigrostriatal overabundance of alpha-synuclein leads to decreased vesicle density and deficits in dopamine release that correlate with reduced motor activity

Patrick Aebischer, Marco Cantoni, Jean-Charles Bensadoun, Graham Knott, Safa Mohanna, Ralf Schneggenburger, Özgür Genç, Wojciech Janusz Bobela

alpha-Synuclein (alpha-syn) is a presynaptic protein present at most nerve terminals, but its function remains largely unknown. The familial forms of Parkinson's disease associated with multiplications of the alpha-syn gene locus indicate that overabundanc ...

Springer-Verlag2012

Imaging brain amyloid deposition using grating-based differential phase contrast tomography

Patrick Aebischer, Jean-Charles Bensadoun, Peter Modregger, Marco Stampanoni

One of the core pathological features of Alzheimer's disease (AD) is the accumulation of amyloid plaques in the brain. Current efforts of medical imaging research aim at visualizing amyloid plaques in living patients in order to evaluate the progression of ...

Elsevier2012

Proton and phosphorus magnetic resonance spectroscopy of a mouse model of Alzheimer's disease

Patrick Aebischer, Bernard Schneider, Rolf Gruetter, Hongxia Lei, Cristina Ramona Cudalbu, Sharon Janssens, Lili Sun-Reimer

The development of new diagnostic criteria for Alzheimer's disease (AD) requires new in vivo markers reflecting early pathological changes in the brain of patients. Magnetic resonance (MR) spectroscopy has been shown to provide useful information about the ...

Ios Press2012

Parkinson's Disease: Gene Therapies

Patrick Aebischer, Bernard Schneider, Philippe Guillaume Coune

With the recent development of effective gene delivery systems, gene therapy for the central nervous system is finding novel applications. Here, we review existing viral vectors and discuss gene therapy strategies that have been proposed for Parkinson's di ...

Cold Spring Harbor Lab Press, Publications Dept2012

How to build science capacity

Patrick Aebischer

Nature Publishing Group2012

Use of viral vectors to create animal models for Parkinson's disease

Patrick Aebischer

Parkinson's disease is a neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons in the substantia nigra. While sporadic in the majority of cases. PD-linked dominant mutations in the a-synuclein and LRRK-2 genes, and recess ...

Elsevier2012

System and Method For In Vivo Delivery of Antibodies and Fragments Thereof

Patrick Aebischer, Nicolas Bouche, Maurizio Molinari

The present invention is directed to devices and methods for in situ delivering an antibody or a fragment thereof to a host. In particular, the invention relates to devices and methods for in situ delivering an antibody or a fragment thereof to patient suf ...

2011

Chronic delivery of antibody fragments using immunoisolated cell implants as a passive vaccination tool

Patrick Aebischer, Nicolas Bouche, Jean-Charles Bensadoun, Maria del Carmen Sandi Perez, Rolf Gruetter, Maria Isabel Cordero Campana, Osiris Marroquin Belaunzaran, Veronica Setola, Maurizio Molinari

BACKGROUND: Monoclonal antibodies and antibody fragments are powerful biotherapeutics for various debilitating diseases. However, high production costs, functional limitations such as inadequate pharmacokinetics and tissue accessibility are the current pri ...

Public Library of Science2011

Proton and phosphorus MRS of a 5xFAD mouse model of Alzheimer's disease

Patrick Aebischer, Bernard Schneider, Rolf Gruetter, Hongxia Lei, Sharon Janssens, Lili Sun-Reimer

2011

Use of igf-1 and nt-3 in the treatment of x-linked adrenoleukodystrophy

Patrick Aebischer, Jean-Charles Bensadoun

The present invention is directed to new compositions uses thereof and related methods for the treatment of X- linked adrenoleukodystrophy. ...

2010

Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions

Patrick Aebischer, Bernard Schneider, Hilal Lashuel, Adrian Schmid, Marc Moniatte, Diego Chiappe, Abid Oueslati, Magdalena Zweckstetter

Increasing evidence suggests that phosphorylation may play an important role in the oligomerization, fibrillogenesis, Lewy body (LB) formation, and neurotoxicity of alpha-synuclein (alpha-syn) in Parkinson disease. Herein we demonstrate that alpha-syn is p ...

2010

Neurodegenerative Disorders: Gene Therapy on Clinical Trial

Patrick Aebischer

Frontiers Research Foundation2010

Neuroprotection by Gene Therapy Targeting Mutant SOD1 in Individual Pools of Motor Neurons Does not Translate Into Therapeutic Benefit in fALS Mice

Patrick Aebischer, Bernard Schneider, Christopher Towne, Veronica Setola

A major challenge in neurological gene therapy is delivery of the transgene to sufficient cell numbers in an atraumatic manner. This is particularly difficult for motor neuron (MN) diseases that have cells located across the entire spinal cord, brain stem, ...

Elsevier2010

Efficient transduction of non-human primate motor neurons after intramuscular delivery of recombinant AAV serotype 6

Patrick Aebischer, Bernard Schneider, Christopher Towne

Retrograde transport of viral vectors in the rodent spinal cord provides a powerful means to administer a therapeutic transgene from the innervated musculature. With the aim of scaling up this approach to non-human primates, we have injected recombinant ad ...

2010

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