Publications de Veronica Gambillara

Reduced cyclic stretch, endothelial dysfunction, and oxidative stress: an ex vivo model

Nikolaos Stergiopoulos, Veronica Gambillara, Paolo Silacci, Tyler Nerton Thacher, Rafaela Fernandes Da Silva

The objective of this study was to investigate whether reduction of cyclic circumferential stretch will impair endothelial function and elevate basal levels of oxidative stress, both known risk factors linked to cardiovascular disease. ...

2009

Regulation of arginase pathway in response to wall shear stress

Nikolaos Stergiopoulos, Veronica Gambillara, Paolo Silacci, Fabienne Riche, Tyler Nerton Thacher, Rafaela Fernandes Da Silva

Alterations of wall shear stress can predispose the endothelium to the development of atherosclerotic plaques. Ample evidence indicates that arginase expression and/or activity correlates with several risk factors for cardiovascular disease including ather ...

2009

Effects Of Reduced Compliance On Endothelial Functionality With Regards To Inflammation

Nikolaos Stergiopoulos, Veronica Gambillara, Paolo Silacci, Tyler Nerton Thacher, Rafaela Fernandes Da Silva

American Soc Mechanical Engineers, Three Park Avenue, New York, Ny 10016-5990 Usa2009

Effects of reduced cyclic stretch on vascular smooth muscle cell function of pig carotids perfused ex vivo

Nikolaos Stergiopoulos, Veronica Gambillara, Paolo Silacci, Tyler Nerton Thacher

With advancing age arteries stiffen, reducing arterial compliance and leading to the development of systolic hypertension and to a substantial increase in pulse pressure. An augmented pulse pressure can be a predictor of the development of hypertension, wh ...

Oxford University Press2008

Role of arginase pathway in response to shear stress: new potential therapeutic targets for atherosclerosis?

Nikolaos Stergiopoulos, Veronica Gambillara, Rafaela Fernandes Da Silva

Introduction: Alterations of wall shear stress can predispose the endothelium to the development of atherosclerotic plaques. Ample evidence indicates that arginase expression and/or activity correlates with several risk factors for cardiovascular disease i ...

2007

Oscillatory shear stress and reduced compliance impair vascular functions

Nikolaos Stergiopoulos, Veronica Gambillara, Paolo Silacci, Tyler Nerton Thacher, Rafaela Fernandes Da Silva

Shear stress has been shown to influence endothelial cell gene expression and morphology. In particular, low and bi-directional shear stress, mimicking conditions at plaque-prone areas, down-regulates the expression of several atheroprotective genes, and u ...

2007

Plaque-prone hemodynamics impair endothelial function in pig carotid arteries

Nikolaos Stergiopoulos, Veronica Gambillara, Paolo Silacci, Sylvain Roy

Hemodynamic forces play an active role in vascular pathologies, particularly in relation to the localization of atherosclerotic lesions. It has been established that low shear stress combined with cyclic reversal of flow direction (oscillatory shear stress ...

2006

Arterial wall response to ex vivo exposure to oscillatory shear stress

Nikolaos Stergiopoulos, Veronica Gambillara, Paolo Silacci

The aim of this study was to analyze the arterial wall response to plaque-prone hemodynamic environments, known to occur mainly in areas of arterial trees such as bifurcations and branching points. In these areas, the vasculature is exposed to cyclically r ...

2005

Effect of intimal shear and cyclic strech on arterial segments perfused in vitro

Veronica Gambillara

Hemodynamics have crucial role in the control of vascular tone, in the regulation of arterial remodeling, and in the production of mediators that maintain arterial function. Changes in hemodynamics forces induce profound alterations in vascular cell metabo ...

EPFL2005