Publications de Simone Bonazzi

Anguinomycins and Derivatives: Total Syntheses, Modeling, and Biological Evaluation of the Inhibition of Nucleocytoplasmic Transport

Simone Bonazzi, Karl Gademann, Jean-Yves Wach, Ivo Zemp

The preparation of the polyketide natural products anguinomycin C and D is reported based on key steps such as Negishi stereoinversion cross coupling, Jacobsen Cr(III)-catalyzed Hetero Diels−Alder reaction, Evans B-mediated syn-aldol chemistry, and B-alkyl ...

2010

Synthetic Studies on the Sporolides: Exploration of the Enediyne Route

Massimo Binaghi, Simone Bonazzi, Cindy Fellay, Karl Gademann, Jean-Yves Wach

Synthetic studies towards the construction of the cyclopenta[a]indene fragment of the heptacyclic marine metabolite sporolide are reported based on a hypothetical biosynthesis. The key step of this biogenetic proposal includes a Bergman cyclization of an e ...

Georg Thieme Verlag2010

Antimalarial and antitubercular nostocarboline and eudistomin derivatives: synthesis, in vitro and in vivo biological evaluation

Simone Bonazzi, Luc Patiny, Rosario Scopelliti, Karl Gademann, Stewart Cole

The synthesis of nine nostocarboline derivatives with substitutions of the 2-methyl group by alkyl, aryl and functionalized residues, 10 symmetrical bis cationic dimers linking 6-Cl-norharmane through the 2-position and fifteen derivatives of the marine al ...

2010

Antimicrobial Surfaces through Natural Product Hybrids

Simone Bonazzi, Karl Gademann, Jean-Yves Wach

The power of two! A natural product hybrid (see structure) composed of a siderophore and an antibiotic separated by a poly(ethylene glycol) linker enables the preparation of antimicrobial and cell-resistant surfaces by a simple dip-and-rinse procedure. The ...

Wiley-VCH Verlag GmbH2008

Protein-Resistant Surfaces through Mild Dopamine Surface Functionalization

Simone Bonazzi, Karl Gademann, Jean-Yves Wach

The synthesis and evaluation of new dopamine-based catechol anchors coupled to poly(ethylene glycol) (PEG) for surface modification of TiO2 are reported. Dopamine is modified by dimethylamine-methylene or trimethylammonium- methylene groups, and the prepar ...

2008

Total Synthesis, Configuration, and Biological Evaluation of Anguinomycin C

Simone Bonazzi, Karl Gademann, Ivo Zemp

Immunofluorescence assays indicate that anguinomycin C is a potent inhibitor of protein export from the nucleus. Key features in the total synthesis of this antitumor natural product include a Cr-catalyzed enantioselective hetero-Diels– Alder reaction, a N ...

Wiley-VCH Verlag GmbH2007

Simone Bonazzi

Graph Chatbot

Anguinomycins and Derivatives: Total Syntheses, Modeling, and Biological Evaluation of the Inhibition of Nucleocytoplasmic Transport

Synthetic Studies on the Sporolides: Exploration of the Enediyne Route

Antimalarial and antitubercular nostocarboline and eudistomin derivatives: synthesis, in vitro and in vivo biological evaluation

Antimicrobial Surfaces through Natural Product Hybrids

Protein-Resistant Surfaces through Mild Dopamine Surface Functionalization

Total Synthesis, Configuration, and Biological Evaluation of Anguinomycin C

Total Synthesis of Complex Cyanobacterial Alkaloids Without Using Protecting Groups

Combining Devices and Drugs by Synthetic Natural Product Hybrids

Bridged Dihydroxypyridine Ligands for the Synthesis of Expanded Helicates