Publications de Liliane Glauser

Chromatin plasticity predetermines neuronal eligibility for memory trace formation

Liliane Glauser, Maria del Carmen Sandi Perez, Marion Leleu, Johannes Gräff, Simone Astori, Giulia Santoni

Memories are encoded by sparse populations of neurons but how such sparsity arises remains largely unknown. We found that a neuron’s eligibility to be recruited into the memory trace depends on its epigenetic state prior to encoding. Principal neurons in t ...

American Association for the Advancement of Science2024

An Epigenetic Contribution to Neuronal Competition During Memory Allocation

Liliane Glauser, Giulia Santoni, Ana Beatriz Reis dos Santos Marques

SPRINGERNATURE2021

Comprehensive analysis of PM20D1 QTL in Alzheimer's disease

Liliane Glauser, Johannes Gräff, Jose Vicente Sanchez Mut

Background Alzheimer's disease (AD) is a complex disorder caused by a combination of genetic and non-genetic risk factors. In addition, an increasing evidence suggests that epigenetic mechanisms also accompany AD. Genetic and epigenetic factors are not ind ...

2020

Membrane activity detection in cultured cells using phase-sensitive plasmonics

Liliane Glauser, Johannes Gräff, Xiaokang Li, Jose Vicente Sanchez Mut, Yasaman Jahani, Foziyeh Sohrabi, Ershad Mohammadi

Despite the existence of various neural recording and mapping techniques, there is an open territory for the emergence of novel techniques. The current neural imaging and recording techniques suffer from invasiveness, a time-consuming labeling process, poo ...

2020

PM20D1 is a quantitative trait locus associated with Alzheimer’s disease

Liliane Glauser, Bernard Schneider, Johannes Gräff, Lucie Pauline Dixsaut, Jose Vicente Sanchez Mut, Bianca Ambrogina Silva

2018

Reactivation of recall-induced neurons contributes to remote fear memory attenuation

Liliane Glauser, Victoire Gorden, Ossama Mohamed Salah El-Dien El-Sayed Ibrahim Khalaf, Johannes Gräff, Lucie Pauline Dixsaut, Siegfried Resch

American Association for the Advancement of Science2018

Parkin mediates the ubiquitination of VPS35 and modulates retromer-dependent endosomal sorting

Liliane Glauser, Darren Moore, Elpida Tsika

Mutations in a number of genes cause familial forms of Parkinson's disease (PD), including mutations in the vacuolar protein sorting 35 ortholog (VPS35) and parkin genes. In this study, we identify a novel functional interaction between parkin and VPS35. W ...

Oxford University Press2018

alpha-Synuclein-induced dopaminergic neurodegeneration in a rat model of Parkinson's disease occurs independent of ATP13A2 (PARK9)

Liliane Glauser, Bernard Schneider, Darren Moore, Alessandra Musso, Elpida Tsika, Aris Nikolaos Fiser, Guillaume Daniel

Mutations in the ATP13A2 (PARK9) gene cause early-onset, autosomal recessive Parkinson's disease (PD) and Kufor-Rakeb syndrome. ATP13A2 mRNA is spliced into three distinct isoforms encoding a P5-type ATPase involved in regulating heavy metal transport acro ...

Academic Press Inc Elsevier Science2015

A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity

Patrick Aebischer, Liliane Glauser, Bernard Schneider, Julien Dusonchet, Klodjan Stafa, Darren Moore

Mutations in LRRK2 are one of the primary genetic causes of Parkinson's disease (PD). LRRK2 contains a kinase and a GTPase domain, and familial PD mutations affect both enzymatic activities. However, the signaling mechanisms regulating LRRK2 and the pathog ...

Oxford University Press2014

Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration

Liliane Glauser, Bernard Schneider, Darren Moore, Elpida Tsika, Aris Nikolaos Fiser, Guillaume Daniel

Mutations in the vacuolar protein sorting 35 homolog (VPS35) gene at the PARK17 locus, encoding a key component of the retromer complex, were recently identified as a new cause of late-onset, autosomal dominant Parkinson's disease (PD). Here we explore the ...

Oxford University Press2014

Functional interaction of Parkinsons disease-associated LRRK2 with members of the dynamin GTPase superfamily

Liliane Glauser, Amy Jones, Klodjan Stafa, Darren Moore, Alessandra Musso, Elpida Tsika

Mutations in LRRK2 cause autosomal dominant Parkinsons disease (PD). LRRK2 encodes a multi-domain protein containing GTPase and kinase domains, and putative proteinprotein interaction domains. Familial PD mutations alter the GTPase and kinase activity of L ...

Oxford University Press2014

Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration

Liliane Glauser, Graham Knott, Darren Moore, Elpida Tsika, Meghna Kannan, Shi-Yan Caroline Foo

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause late-onset, autosomal dominant Parkinson's disease (PD). The clinical and neurochemical features of LRRK2-linked PD are similar to idiopathic disease although neuropathology is somewhat heter ...

Elsevier2014

GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2

Liliane Glauser, Darren Moore, Alzbeta Trancikova

Oxford University Press2013

PARK9-associated ATP13A2 localizes to intracellular acidic vesicles and regulates cation homeostasis and neuronal integrity

Liliane Glauser, Sarah Catherine Sonnay, Klodjan Stafa, Darren Moore, David Ramonet Jimenez, Agata Podhajska, Alzbeta Trancikova, Elpida Tsika

Mutations in the ATP13A2 gene (PARK9, OMIM 610513) cause autosomal recessive, juvenile-onset Kufor-Rakeb syndrome and early-onset parkinsonism. ATP13A2 is an uncharacterized protein belonging to the P-5-type ATPase subfamily that is predicted to regulate t ...

Oxford University Press2012

GTPase Activity and Neuronal Toxicity of Parkinson's Disease-Associated LRRK2 Is Regulated by ArfGAP1

Liliane Glauser, Klodjan Stafa, Darren Moore, Alzbeta Trancikova

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common cause of autosomal dominant familial Parkinson's disease (PD) and also contribute to idiopathic PD. LRRK2 encodes a large multi-domain protein with GTPase and kinase activity. I ...

Public Library of Science2012

Common Pathogenic Effects of Missense Mutations in the P-Type ATPase ATP13A2 (PARK9) Associated with Early-Onset Parkinsonism

Liliane Glauser, Sarah Catherine Sonnay, Klodjan Stafa, Darren Moore, Agata Podhajska, Alessandra Musso, Alzbeta Trancikova

Mutations in the ATP13A2 gene (PARK9) cause autosomal recessive, juvenile-onset Kufor-Rakeb syndrome (KRS), a neurodegenerative disease characterized by parkinsonism. KRS mutations produce truncated forms of ATP13A2 with impaired protein stability resultin ...

Public Library of Science2012

Phosphorylation of 4E-BP1 in the Mammalian Brain Is Not Altered by LRRK2 Expression or Pathogenic Mutations

Liliane Glauser, Klodjan Stafa, Darren Moore, Alzbeta Trancikova, Elpida Tsika

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are a common cause of autosomal dominant familial Parkinson's disease (PD). LRRK2 encodes a multi-domain protein containing GTPase and kinase enzymatic domains. Disease-associated mutations in LRRK ...

Public Library of Science2012

Parkin promotes the ubiquitination and degradation of the mitochondrial fusion factor mitofusin 1

Liliane Glauser, Sarah Catherine Sonnay, Klodjan Stafa, Darren Moore

Mutations in the parkin gene cause early-onset, autosomal recessive Parkinson's disease. Parkin functions as an E3 ubiquitin ligase to mediate the covalent attachment of ubiquitin monomers or linked chains to protein substrates. Substrate ubiquitination ca ...

2011

Dopaminergic Neuronal Loss, Reduced Neurite Complexity and Autophagic Abnormalities in Transgenic Mice Expressing G2019S Mutant LRRK2

Liliane Glauser, Klodjan Stafa, Darren Moore, David Ramonet Jimenez, Ying Liu

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause late-onset, autosomal dominant familial Parkinson's disease (PD) and also contribute to idiopathic PD. LRRK2 mutations represent the most common cause of PD with clinical and neurochemical fe ...

Public Library of Science2011

Subunit-specific surface mobility of differentially labeled AMPA receptor subunits

Kai Johnsson, Liliane Glauser, Harald Hirling, Karina Kulangara, Guillaume Rey, Michel Kropf

Elsevier2008