Publications de Michal Dabros | EPFL Graph Search

Reactor Dynamics Investigation Based On Calorimetric Data

Thierry Meyer, Francis Stoessel, Michal Dabros, Charles Ibrahim Guinand

A simple and general procedure has been developed to determine the thermal behaviour of a reactor based on heat balance, PID temperature control, and jacket behaviour. Using only temperature heating/cooling ramps followed by isothermal stages, such a proce ...

Wiley-Blackwell2017

Thermal Process Safety Based on Reaction Kinetics and Reactor Dynamics

Thierry Meyer, Francis Stoessel, Michal Dabros, Charles Ibrahim Guinand

The specific problem of non-converted reactant accumulation encountered in fed-batch reactor is a challenging task of process safety. In order to avoid such situation that may lead to a runaway reaction, the reaction kinetics and reactor dynamic must be kn ...

Aidic Servizi Srl2016

Data Reconciliation of Concentration Estimates from Mid-Infrared and Dielectric Spectral Measurements for Improved On-Line Monitoring of Bioprocesses

Michael Amrhein, Dominique Bonvin, Ian William Marison, Urs von Stockar, Michal Dabros

Real-time data reconciliation of concentration estimates of process analytes and biomass in microbial fermentations is investigated. A Fourier-transform mid-infrared spectrometer predicting the concentrations of process metabolites is used in parallel with ...

2009

Cole-Cole, linear and multivariate modeling of capacitance data for on-line monitoring of biomass

Ian William Marison, Urs von Stockar, Danielle Dennewald, Michal Dabros

This work evaluates three techniques of calibrating capacitance (dielectric) spectrometers used for on-line monitoring of biomass: modeling of cell properties using the theoretical Cole-Cole equation, linear regression of dual-frequency capacitance measure ...

Springer-Verlag2009

Robust model development and enhancement techniques for improved on-line spectroscopic monitoring of bioprocesses

Michal Dabros

The recent phenomenal growth of the field of biotechnology has contributed to a mounting pressure to improve process efficiency and productivity and to increase the quality and safety of end-products. This demand gave rise to the discipline of on-line biop ...

EPFL2008

On-Line Recalibration of Spectral Measurements Using Metabolite Injections and Dynamic Orthogonal Projection

Michael Amrhein, Urs von Stockar, Michal Dabros, Pamandeep Singh Gujral

Spectrometers are enjoying increasing popularity in bioprocess monitoring due to their non-invasiveness and in-situ sterilizability. Their on-line applicability and high measurement frequency create an interesting opportunity for process control and optimi ...

2007