Julien Dusonchet

Cette personne n’est plus à l’EPFL

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Mentions légales

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Publications associées (4)

Exogenous LRRK2(G2019S) induces parkinsonian-like pathology in a nonhuman primate

Bernard Schneider, Julien Dusonchet

2018

A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity

Patrick Aebischer, Liliane Glauser, Bernard Schneider, Julien Dusonchet, Klodjan Stafa, Darren Moore

Mutations in LRRK2 are one of the primary genetic causes of Parkinson's disease (PD). LRRK2 contains a kinase and a GTPase domain, and familial PD mutations affect both enzymatic activities. However, the signaling mechanisms regulating LRRK2 and the pathog ...

Oxford University Press2014

Modeling Parkinson's Disease in Adult Rats Using Viral Vectors as Gene Delivery Tools

Julien Dusonchet

Animal models of human pathologies remain invaluable tools for unraveling disease mechanisms and evaluating potential therapeutic strategies. For a number of diseases, the lack of a reliable animal model represents an important limiting step towards the de ...

EPFL2010

Targeted overexpression of the parkin substrate Pael-R in the nigrostriatal system of adult rats to model Parkinson's disease

Patrick Aebischer, Jean-Charles Bensadoun, Bernard Schneider, Julien Dusonchet

Loss of function of parkin, an ubiquitin ligase, is responsible for autosomal recessive juvenile parkinsonism (AR-JP). Parkin-associated endothelin receptor-like receptor (Pael-R) was identified as an authentic substrate of parkin and is thought to accumul ...

2009

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