Publications de Michele Giugliano

Markov Models of Ion Channels

Springer Science+Business Media2022

Locomotion modulates specific functional cell types in the mouse visual thalamus

The visual system is composed of diverse cell types that encode distinct aspects of the visual scene and may form separate processing channels. Here we present further evidence for that hypothesis whereby functional cell groups in the dorsal lateral genicu ...

Springer Nature2018

Dynamical response properties of neocortical neurons to conductance-driven time-varying inputs

Michele Giugliano

2018

Human Pluripotent Stem-Cell-Derived Cortical Neurons Integrate Functionally into the Lesioned Adult Murine Visual Cortex in an Area-Specific Way

Michele Giugliano

2018

Single-layer graphene modulates neuronal communication and augments membrane ion currents

Michele Giugliano

2018

Diamond microelectrode arrays for in vitro neuronal recordings

Michele Giugliano

A novel microfabrication technique for microelectrode arrays (MEAs) with a full diamond-cell interface is demonstrated. Boron-doped nano-crystalline diamond (BNCD) is used as a conductive electrode material on metal tracks insulated by intrinsic NCD. MEAs ...

Cambridge Univ Press2017

All-diamond functional surface micro-electrode arrays for brain-slice neural analysis

Ladislav Kavan, Michele Giugliano

Diamond-based microelectrode arrays were fabricated by using nanocrystalline diamond as an insulating layer and conductive boron-doped in order to used them for analysis of brain cortical slices. MEA surface is solely composed of diamond, exposed to the ce ...

Wiley-VCH Verlag2017

Brief wide-field photostimuli evoke and modulate oscillatory reverberating activity in cortical networks

Michele Giugliano

Cell assemblies manipulation by optogenetics is pivotal to advance neuroscience and neuroengineering. In in vivo applications, photostimulation often broadly addresses a population of cells simultaneously, leading to feed-forward and to reverberating respo ...

Nature Research2016

The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A

Michele Giugliano

Neuronal function is highly sensitive to changes in oxygen levels, but how hypoxia affects dendritic spine formation and synaptogenesis is unknown. Here we report that hypoxia, chemical inhibition of the oxygen-sensing prolyl hydroxylase domain proteins (P ...

Elsevier2016

On the Firing Rate Dependency of the Phase Response Curve of Rat Purkinje Neurons In Vitro

Michele Giugliano

Synchronous spiking during cerebellar tasks has been observed across Purkinje cells: however, little is known about the intrinsic cellular mechanisms responsible for its initiation, cessation and stability. The Phase Response Curve (PRC), a simple input-ou ...

Public Library Science2015

Adaptation of short-term plasticity parameters via error-driven learning may explain the correlation between activity-dependent synaptic properties, connectivity motifs and target specificity

Michele Giugliano, Eleni Vasilaki

The anatomical connectivity among neurons has been experimentally found to be largely non-random across brain areas. This means that certain connectivity motifs occur at a higher frequency than would be expected by chance. Of particular interest, short-ter ...

Frontiers Research Foundation2015

Duration of Purkinje cell complex spikes increases with their firing frequency

Michele Giugliano

Climbing fiber (CF) triggered complex spikes (CS) are massive depolarization bursts in the cerebellar Purkinje cell (PC), showing several high frequency spikelet components (+/- 600 Hz). Since its early observations, the CS is known to vary in shape. In th ...

Frontiers Research Foundation2015

alpha-Synuclein strains cause distinct synucleinopathies after local and systemic administration

Michele Giugliano

Misfolded protein aggregates represent a continuum with overlapping features in neurodegenerative diseases, but differences in protein components and affected brain regions(1). The molecular hallmark of synucleinopathies such as Parkinson's disease, dement ...

Nature Publishing Group2015

Carbon-based smart nanomaterials in biomedicine and neuroengineering (vol 5, pg 1849, 2014)

Michele Giugliano

Beilstein-Institut2015

Markov Models of Ion Channels

Michele Giugliano

Springer New York2015

Measuring Symmetry, Asymmetry and Randomness in Neural Network Connectivity

Michele Giugliano, Eleni Vasilaki

Cognitive functions are stored in the connectome, the wiring diagram of the brain, which exhibits non-random features, so-called motifs. In this work, we focus on bidirectional, symmetric motifs, i.e. two neurons that project to each other via connections ...

Public Library of Science2014

High Bandwidth Synaptic Communication and Frequency Tracking in Human Neocortex

Michele Giugliano

Neuronal firing, synaptic transmission, and its plasticity form the building blocks for processing and storage of information in the brain. It is unknown whether adult human synapses are more efficient in transferring information between neurons than roden ...

Public Library Science2014

Emergence of Connectivity Motifs in Networks of Model Neurons with Short- and Long-Term Plastic Synapses

Michele Giugliano, Eleni Vasilaki

Recent experimental data from the rodent cerebral cortex and olfactory bulb indicate that specific connectivity motifs are correlated with short-term dynamics of excitatory synaptic transmission. It was observed that neurons with short-term facilitating sy ...

Public Library of Science2014

QSpike tools: a generic framework for parallel batch preprocessing of extracellular neuronal signals recorded by substrate nnicroelectrode arrays

Michele Giugliano, Eleni Vasilaki

Micro-Electrode Arrays (MEAs) have emerged as a mature technique to investigate brain (dys)functions in vivo and in in vitro animal models. Often referred to as "smart" Petri dishes, MEAs have demonstrated a great potential particularly for medium-throughp ...

Frontiers Research Foundation2014

Command-line cellular electrophysiology for conventional and real-time closed-loop experiments

Michele Giugliano

Background: Current software tools for electrophysiological experiments are limited in flexibility and rarely offer adequate support for advanced techniques such as dynamic clamp and hybrid experiments, which are therefore limited to laboratories with a si ...

Elsevier Science Bv2014