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Michele Giugliano

Cette personne n’est plus à l’EPFL

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Publications associées (39)

Synaptic dynamics contribute to long-term single neuron response fluctuations

Michele Giugliano

Firing rate variability at the single neuron level is characterized by long-memory processes and complex statistics over a wide range of time scales (from milliseconds up to several hours). Here, we focus on the contribution of non-stationary efficacy of t ...

Frontiers Research Foundation2014

Carbon-based smart nanomaterials in biomedicine and neuroengineering

Michele Giugliano

The search for advanced biomimetic materials that are capable of offering a scaffold for biological tissues during regeneration or of electrically connecting artificial devices with cellular structures to restore damaged brain functions is at the forefront ...

Beilstein-Institut2014

Pyramidal Neurons Derived from Human Pluripotent Stem Cells Integrate Efficiently into Mouse Brain Circuits In Vivo

Michele Giugliano

The study of human cortical development has major implications for brain evolution and diseases but has remained elusive due to paucity of experimental models. Here we found that human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), ...

Cell Press2013

Hyperconnectivity and Slow Synapses during Early Development of Medial Prefrontal Cortex in a Mouse Model for Mental Retardation and Autism

Michele Giugliano

Neuronal theories of neurodevelopmental disorders (NDDs) of autism and mental retardation propose that abnormal connectivity underlies deficits in attentional processing. We tested this theory by studying unitary synaptic connections between layer 5 pyrami ...

Oxford University Press2012

Method for in-vitro monitoring of neuronal disorders and use thereof

Luca Gambazzi, Henry Markram, Michele Giugliano

The present invention relates to methods and neuronal cellular preparations allowing monitoring intracellular and transcellular molecular events on both short and long timescales in an ex vivo neuronal network of intact post-mitotic neurons. In particular, ...

2012

Accurate and Fast Simulation of Channel Noise in Conductance-Based Model Neurons by Diffusion Approximation

Michele Giugliano

Stochastic channel gating is the major source of intrinsic neuronal noise whose functional consequences at the microcircuit- and network-levels have been only partly explored. A systematic study of this channel noise in large ensembles of biophysically det ...

2011

Multiwalled Carbon-Nanotube-Functionalized Microelectrode Arrays Fabricated by Microcontact Printing: Platform for Studying Chemical and Electrical Neuronal Signaling

Luca Gambazzi, Michele Giugliano

A facile method is proposed for the deposition of multiwalled carbon nanotube (MWCNT) layers onto microelectrode arrays by means of a microcontact printing technique, leading to the fabrication of MEAs characterized by well defined electrical and morpholog ...

2011

Chloride Ions in the Pore of Glycine and GABA Channels Shape the Time Course and Voltage Dependence of Agonist Currents

Michele Giugliano

In the vertebrate CNS, fast synaptic inhibition is mediated by GABA and glycine receptors. We recently reported that the time course of these synaptic currents is slower when intracellular chloride is high. Here we extend these findings to measure the effe ...

2011

Micropatterning neural cell cultures in 3D with a multi-layered scaffold

Philippe Renaud, Anja Kunze, Michele Giugliano, Ana Valero

Cortical neurons, in their native state, are organized in six different cell layers; and the thickness of the cell layer ranges from 0.12 mm to 0.4 mm. The structure of cell layers plays an important role in neurodegenerative diseases or corticogenesis. We ...

2011

Enduring medial perforant path short-term synaptic depression at high pressure

Michele Giugliano

The high pressure neurological syndrome develops during deep-diving (> 1.1 MPa) involving impairment of cognitive functions, alteration of synaptic transmission and increased excitability in cortico-hippocampal areas. The medial perforant path (MPP), conne ...

2010

Long-Term Depression at Parallel Fiber to Golgi Cell Synapses

Michele Giugliano

Robberechts Q, Wijnants M, Giugliano M, De Schutter E. Longterm depression at parallel fiber to Golgi cell synapses. J Neurophysiol 104: 3413-3423, 2010. First published September 22, 2010; doi:10.1152/jn.00030.2010. Golgi cells (GoCs) are the primary inhi ...

2010

Diminished activity-dependent brain-derived neurotrophic factor expression underlies cortical neuron microcircuit hypoconnectivity resulting from exposure to mutant huntingtin fragments

Luca Gambazzi, Henry Markram, Heike Runne, Ozgün Gökce, Michele Giugliano, Elena Katsyuba

Although previous studies of Huntington's disease (HD) have addressed many potential mechanisms of striatal neuron dysfunction and death, it is also known, based on clinical findings, that cortical function is dramatically disrupted in HD. With respect to ...

American Society for Pharmacology and Experimental Therapeutics2010

Substrate arrays of iridium oxide microelectrodes for in-vitro neuronal interfacing

Marc Olivier Heuschkel, Shady Didier Gawad, Philippe Renaud, Henry Markram, Michele Giugliano

The design of novel bidirectional interfaces for in vivo and in vitro nervous systems is an important step towards future functional neuroprosthetics. Small electrodes, structures and devices are necessary to achieve high-resolution and target-selectivity ...

2009

Carbon nanotubes might improve neuronal performance by favouring electrical shortcuts

Luca Gambazzi, Henry Markram, Michele Giugliano

Carbon nanotubes have been applied in several areas of nerve tissue engineering to probe and augment cell behaviour, to label and track subcellular components, and to study the growth and organization of neural networks. Recent reports show that nanotubes ...

Nature Publishing Group2009

The dynamical response properties of neocortical neurons to temporally modulated noisy inputs in vitro

Michele Giugliano

Cortical neurons are often classified by current-frequency relationship. Such a static description is inadequate to interpret neuronal responses to time-varying stimuli. Theoretical studies suggested that single-cell dynamical response properties are neces ...

Oxford University Press2008

Inferring connection proximity in networks of electrically coupled cells by subthreshold frequency response analysis

Henry Markram, Michele Pignatelli, Thomas Berger, Michele Giugliano, Corrado Cali

Electrical synapses continuously transfer signals bi-directionally from one cell to another, directly or indirectly via intermediate cells. Electrical synapses are common in many brain structures such as the inferior olive, the subcoeruleus nucleus and the ...

Springer US2008

The response of cortical neurons to in vivo-like input current: theory and experiment

Walter Senn, Michele Giugliano

The study of several aspects of the collective dynamics of interacting neurons can be highly simplified if one assumes that the statistics of the synaptic input is the same for a large population of similarly behaving neurons (mean field approach). In part ...

2008

The response of cortical neurons to in vivo-like input current: theory and experiment: II. Time-varying and spatially distributed inputs

Walter Senn, Michele Giugliano

The response of a population of neurons to time-varying synaptic inputs can show a rich phenomenology, hardly predictable from the dynamical properties of the membrane's inherent time constants. For example, a network of neurons in a state of spontaneous a ...

Springer-Verlag2008

Interfacing neurons with carbon nanotubes: electrical signal transfer and synaptic stimulation in cultured brain circuits

Luca Gambazzi, Henry Markram, Michele Giugliano

The unique properties of single-wall carbon nanotubes (SWNTs) and the application of nanotechnology to the nervous system may have a tremendous impact in the future developments of microsystems for neural prosthetics as well as immediate benefits for basic ...

2007

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