Carbon-13 nuclear magnetic resonance spectroscopy in combination with the infusion of (13)C-labeled precursors is a unique approach to study in vivo brain energy metabolism. Incorporating the maximum information available from in vivo localized (13)C spect ...

Sage Publications Ltd2016

Glutathione deficit affects the integrity and function of the fimbria/fornix and anterior commissure in mice: relevance for schizophrenia

Rolf Gruetter, João Miguel das Neves Duarte, Yohan Van de Looij, Aline Monin, Alberto Corcoba, Kim Do

BACKGROUND: Structural anomalies of white matter (WM) are found in various brain regions of patients with schizophrenia, bipolar and other psychiatric disorders, but the causes at cellular and molecular levels remain unclear. Oxidative stress and redox dys ...

Oxford Univ Press2016

Compartmentalised energy metabolism supporting glutamatergic neurotransmission in response to increased activity in the rat cerebral cortex: A 13C MRS study in vivo at 14.1 T

Rolf Gruetter, João Miguel das Neves Duarte, Nathalie Just, Sarah Catherine Sonnay

Many tissues exhibit metabolic compartmentation. In the brain, while there is no doubt on the importance of functional compartmentation between neurons and glial cells, there is still debate on the specific regulation of pathways of energy metabolism at di ...

Nature Publishing Group2016

Adenosine A(1) receptors control the metabolic recovery after hypoxia in rat hippocampal slices

João Miguel das Neves Duarte

Adenosine is a neuromodulator that protects neurons from hypoxia. This effect is attributed to the ability of adenosine A(1) receptors (A(1)R) to inhibit excitatory synaptic transmission. However, A(1)R activation also protects non-brain tissues from hypox ...

Wiley-Blackwell2016

Observation of the rare B-s(0)->mu(+)mu(-) decay from the combined analysis of CMS and LHCb data

Horst Vogel, Christoph Frei, Peter Clarke, Jean Wicht, Alessandro Mapelli, Aurelio Bay, Minh Tâm Tran, Andrea Rizzi, Marc-Olivier Bettler, Cédric Potterat, Matthias Finger, Tatsuya Nakada, Guido Haefeli, Niko Neufeld, Olivier Schneider, Pierre Jaton, Hans Dijkstra, Julien Rouvinet, Charles Dietz, João Miguel das Neves Duarte, Frédéric Guillaume Dupertuis, Frédéric Teubert, Gerhard Raven, Quentin Python, Bastien Luca Muster, Joo Yeon Kim, Alexis Kalogeropoulos, Chitsanu Khurewathanakul, Frédéric Blanc, Matthew Needham, Lesya Shchutska, Liang Sun, Alexandre Aubin, Yixing Chen, Tian Cheng, Ioannis Papadopoulos, Wei Sun, Barinjaka Rakotomiaramanana, Xiaoxue Han, Qian Wang, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,

Brain energy metabolism measured by 13C magnetic resonance spectroscopy in vivo upon infusion of [3-13C]lactate

Rolf Gruetter, João Miguel das Neves Duarte, Freya-Merret Girault

The brain uses lactate produced by glycolysis as an energy source. How lactate originated from the blood stream is used to fuel brain metabolism is not clear. The current study measures brain metabolic fluxes and estimates the amount of pyruvate that becom ...

Wiley-Blackwell2015

Metabolic Alterations Associated to Brain Dysfunction in Diabetes

João Miguel das Neves Duarte

From epidemiological studies it is known that diabetes patients display increased risk of developing dementia. Moreover, cognitive impairment and Alzheimer's disease (AD) are also accompanied by impaired glucose homeostasis and insulin signalling. Although ...

Int Soc Aging & Disease2015

Imaging of prolonged BOLD response in the somatosensory cortex of the rat

Rolf Gruetter, João Miguel das Neves Duarte, Nathalie Just, Sarah Catherine Sonnay

Blood oxygenation level-dependent (BOLD) functional MRI is a widely employed methodology in experimental and clinical neuroscience, although its nature is not fully understood. To gain insights into BOLD mechanisms and take advantage of the new functional ...

Wiley-Blackwell2015

Energy metabolism in the rat cortex under deep thiopental anesthesia measured in vivo by 13C MRS at 14.1 T

Rolf Gruetter, João Miguel das Neves Duarte, Nathalie Just, Sarah Catherine Sonnay

Wiley-Blackwell2015

Metabolic deterioration underlying impaired memory performance in insulin resistance

João Miguel das Neves Duarte

Wiley-Blackwell2015

Evidence From Imaging Studies For Oxidative Stress Mechanisms In First Episode Schizophrenia

Jean-Philippe Thiran, Patric Hagmann, Rolf Gruetter, Lijing Xin, João Miguel das Neves Duarte, Alessandra Griffa, Yohan Van de Looij, Alexander Monin, Alberto Corcoba, Kim Do

Oxford Univ Press2015

Longitudinal neurochemical modifications in the aging mouse brain measured in vivo by 1H magnetic resonance spectroscopy

Rolf Gruetter, João Miguel das Neves Duarte, Kim Do

Alterations to brain homeostasis during development are reflected in the neurochemical profile determined noninvasively by (1)H magnetic resonance spectroscopy. We determined longitudinal biochemical modifications in the cortex, hippocampus, and striatum o ...

Elsevier Science Inc2014

MRS glucose mapping and PET joining forces: Re-evaluation of the lumped constant in the rat brain under isoflurane anaesthesia

Rolf Gruetter, João Miguel das Neves Duarte, Hongxia Lei, Malte Alf

Although numerous positron emission tomography (PET) studies with ((8) F-fluoro-deoxyglucose) FDG have reported quantitative results on cerebral glucose kinetics and consumption, there is a large variation between the absolute values found in the literatur ...

Wiley-Blackwell2014

Impaired White Matter Integrity in Fornix and Anterior Commissure in a Schizophrenia Mouse Model of Redox Dysregulation

Rolf Gruetter, João Miguel das Neves Duarte, Yohan Van de Looij, Alberto Corcoba, Kim Do

Elsevier Science Inc2014

Impact of insulin resistance on memory performance, brain morphology and neurochemical profiles of the cortex and hippocampus

Rolf Gruetter, João Miguel das Neves Duarte

Springer2014

Metabolic flux analysis of acetylcarnitine turnover and mitochondrial oxidation of [2-13C]acetate in rat skeletal muscle in vivo measured by 13C MRS

Rolf Gruetter, João Miguel das Neves Duarte, Josefina Adriana Maria Bastiaansen

2014

Glutamatergic and GABAergic energy metabolism measured in the rat brain by 13C NMR spectroscopy at 14.1 T

Rolf Gruetter, João Miguel das Neves Duarte

Energy metabolism supports both inhibitory and excitatory neurotransmission processes. This study investigated the specific contribution of astrocytic metabolism to γ-aminobutyric acid (GABA) synthesis and inhibitory GABAergic neurotransmission that remain ...

Wiley-Blackwell2013

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The standard model of particle physics describes the fundamental particles and their interactions via the strong, electromagnetic and weak forces. It provides precise predictions for measurable quantities that can be tested experimentally. The probabilitie ...

Nature Publishing Group2015