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João Miguel das Neves Duarte

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Publications associées (130)

Metabolic Flux and Compartmentation Analysis in the Brain In vivo

Bernard Lanz, Rolf Gruetter, João Miguel das Neves Duarte

Through significant developments and progresses in the last two decades, in vivo localized nuclear magnetic resonance spectroscopy (MRS) became a method of choice to probe brain metabolic pathways in a non-invasive way. Beside the measurement of the total ...

2013

In vivo enzymatic activity of acetylCoA synthetase in skeletal muscle revealed by (13)C turnover from hyperpolarized [1-(13)C]acetate to [1-(13)C]acetylcarnitine

Arnaud Comment, Rolf Gruetter, João Miguel das Neves Duarte, Mor-Miri Mishkovsky, Tian Cheng, Josefina Adriana Maria Bastiaansen

BACKGROUND: Acetate metabolism in skeletal muscle is regulated by acetylCoA synthetase (ACS). The main function of ACS is to provide cells with acetylCoA, a key molecule for numerous metabolic pathways including fatty acid and cholesterol synthesis and the ...

Elsevier Science Bv2013

Which prior knowledge? Quantification of in vivo brain (13) C MR spectra following (13) C glucose infusion using AMARES

Nicolas Kunz, Bernard Lanz, Rolf Gruetter, João Miguel das Neves Duarte, Cristina Ramona Cudalbu

The recent developments in high magnetic field (13) C magnetic resonance spectroscopy with improved localization and shimming techniques have led to important gains in sensitivity and spectral resolution of (13) C in vivo spectra in the rodent brain, enabl ...

Wiley-Blackwell2013

The C57BL/6J Mouse Exhibits Sporadic Congenital Portosystemic Shunts

Rolf Gruetter, João Miguel das Neves Duarte, Hongxia Lei, Cristina Ramona Cudalbu

C57BL/6 mice are the most widely used strain of laboratory mice. Using in vivo proton Magnetic Resonance Spectroscopy (1H MRS), we have repeatedly observed an abnormal neurochemical profile in the brains of both wild-type and ge ...

Public Library of Science2013

Acetylcarnitine turnover in rat skeletal muscle measured in vivo using localized 13C NMR at 14.1 T

Arnaud Comment, Rolf Gruetter, João Miguel das Neves Duarte, Josefina Adriana Maria Bastiaansen

2013

Metabolism of [1,6-C-13]glucose in glutamatergic and GABAergic compartments in vivo in the rat brain

Rolf Gruetter, João Miguel das Neves Duarte

Wiley-Blackwell2013

Brain Glucose Transport and Phosphorylation Under Acute Insulin-Induced Hypoglycemia in Mice: An 18F-FDG PET Study

Rolf Gruetter, João Miguel das Neves Duarte, Malte Alf

We addressed the questions of how cerebral glucose transport and phosphorylation change under acute hypoglycemia and what the underlying mechanisms of adaptation are. Methods: Quantitative 18F-FDG PET combined with the acquisition of real-time arterial inp ...

2013

The neurochemical profile quantified by in vivo(1)H NMR spectroscopy

Rolf Gruetter, João Miguel das Neves Duarte, Hongxia Lei

Proton NMR spectroscopy is emerging from translational and preclinical neuroscience research as an important tool for evidence based diagnosis and therapy monitoring. It provides biomarkers that offer fingerprints of neurological disorders even in cases wh ...

2012

N-acetylcysteine normalizes neurochemical changes in the glutathione-deficient schizophrenia mouse model during development

Rolf Gruetter, João Miguel das Neves Duarte, Kim Do

Background: Glutathione (GSH) is the major cellular redox-regulator and antioxidant. Redox-imbalance due to genetically impaired GSH synthesis is among the risk factors for schizophrenia. Here we used a mouse model with chronic GSH deficit induced by knock ...

2012

Kinetic analysis of acetylCoA synthetase activity in skeletal muscle

Arnaud Comment, Rolf Gruetter, João Miguel das Neves Duarte, Mor-Miri Mishkovsky, Tian Cheng, Josefina Adriana Maria Bastiaansen

2012

Characterization of cerebral glucose dynamics in vivo with a four-state conformational model of transport at the blood-brain barrier

Rolf Gruetter, João Miguel das Neves Duarte

Determination of brain glucose transport kinetics in vivo at steady-state typically does not allow distinguishing apparent maximum transport rate (Tmax) from cerebral consumption rate. Using a four-state conformational model of glucose transport, we show t ...

Wiley-Blackwell2012

Metabolism of [1,6-C-13] glucose in glutamatergic and GABAergic compartments in vivo in the rat brain

Rolf Gruetter, João Miguel das Neves Duarte

Wiley-Blackwell2012

Cerebral glutamine metabolism under hyperammonemia determined in vivo by localized H-1 and N-15 NMR spectroscopy

Yves Pilloud, Bernard Lanz, Rolf Gruetter, João Miguel das Neves Duarte, Cristina Ramona Cudalbu

Brain glutamine synthetase (GS) is an integral part of the glutamate-glutamine cycle and occurs in the glial compartment. In vivo Magnetic Resonance Spectroscopy (MRS) allows noninvasive measurements of the concentrations and synthesis rates of metabolites ...

Nature Publishing Group2012

Brain metabolism in glutamatergic and GABAergic compartments detected by in vivo 13C NMR spectroscopy at 14.1 T

Rolf Gruetter, João Miguel das Neves Duarte

2012

Compartmentalized Cerebral Metabolism of [1,6-(13)C]Glucose Determined by in vivo (13)C NMR Spectroscopy at 14.1 T

Bernard Lanz, Rolf Gruetter, João Miguel das Neves Duarte

Cerebral metabolism is compartmentalized between neurons and glia. Although glial glycolysis is thought to largely sustain the energetic requirements of neurotransmission while oxidative metabolism takes place mainly in neurons, this hypothesis is matter o ...

Frontiers Research Foundation2011

Neurochemical profile in the hippocampus of aging mice as detected by in vivo 1H NMR spectroscopy at 14.1 T

Rolf Gruetter, João Miguel das Neves Duarte

2011

Impact of the prior knowledge on the quantification of in vivo 13C spectra using two different algorithms: LCModel and AMARES

Nicolas Kunz, Bernard Lanz, Rolf Gruetter, João Miguel das Neves Duarte, Cristina Ramona Cudalbu

2011

Dynamics of cerebral glucose analysed in vivo with a four-state conformational model

Rolf Gruetter, João Miguel das Neves Duarte

2011

In vivo 13C NMR spectroscopy at 14.1 T

Rolf Gruetter, João Miguel das Neves Duarte

2011

Neurochemical profile of the developing mouse cortex determined by in vivo1H NMR spectroscopy at 14.1 T and the effect of recurrent anaesthesia

Rolf Gruetter, João Miguel das Neves Duarte, Kim Do

P>The neurochemical profile of the cortex develops in a region and time specific manner, which can be distorted by psychiatric and other neurological pathologies. Pre-clinical studies often involve experimental mouse models. In this study, we determined th ...

Wiley-Blackwell2010

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