Publications de Emile Dupont | EPFL Graph Search

Fluorescent magnetic bead and cell differentiation/counting using a CMOS SPAD matrix

Martinus Gijs, Caroline Vandevyver, Edoardo Charbon, Ulrike Lehmann, Emile Dupont

We present a monolithic silicon chip comprising a matrix of 84 single photon avalanche diodes (SPADs) to detect and discriminate fluorescent beads or fluorescently labeled single cells in a polydimethyl(-siloxane) (PDMS) cartridge that is positioned on top ...

Elsevier2012

Microelectronics Meets Biology : Manipulation and Detection of Microparticles and Cells Integrated On-Chip

Emile Dupont

Microfluidics plays a key role in the design of automated platforms for realizing biological assays in a miniaturized format. Several advantages are offered by a microfluidic system, namely, low sample and reagent consumption (typically a few microliters), ...

EPFL2010

Monolithic Silicon Chip for Immunofluorescence Detection on Single Magnetic Beads

Martinus Gijs, Caroline Vandevyver, Edoardo Charbon, Ulrike Lehmann, Emile Dupont

While fluorescence detection is widely used for bioassays owing to its high sensitivity, a complete fluorescent microscopy setup, comprised of a light source, optical filters, a microscope body, and a camera, still is bulky equipment, compromising its use ...

2010

NOA 63 as a UV-curable material for fabrication of microfluidic channels with native hydrophilicity

Martinus Gijs, Raphaelle Luisier, Emile Dupont

In this paper, we propose a method to create a natively hydrophilic microfluidic structure in a fast and simple way using an UV-curable polymer (NOA 63 from Norland Optics). This polymer can provide a substitute to PDMS microchannels offering high reproduc ...

2010

Microparticle photometry in a CMOS microsystem combining magnetic actuation and in-situ optical detection

Martinus Gijs, Cristiano Niclass, Edoardo Charbon, Ulrike Lehmann, Emile Dupont, Stefano Pietrocola

We present a hybrid CMOS-based microfluidic system that combines magnetic actuation of microparticles with in situ optical detection using single photon avalanche diodes (SPADs). The decoupling of the principles used for actuation and sensing permits a hig ...

2008

On-Chip Sandwich Immunoassay in an Integrated Magneto-Optical CMOS Microsystem

Martinus Gijs, Edoardo Charbon, Ulrike Lehmann, Emile Dupont

We report on an innovative approach to on-chip detection of single fluorescently-labeled magnetic micro-particles by means of Single Photon Avalanche Diode (SPAD) arrays. Our system enables particle separation through magnetic actuation and highly sensitiv ...

2008

Emile Dupont

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Fluorescent magnetic bead and cell differentiation/counting using a CMOS SPAD matrix

Microelectronics Meets Biology : Manipulation and Detection of Microparticles and Cells Integrated On-Chip

Monolithic Silicon Chip for Immunofluorescence Detection on Single Magnetic Beads

NOA 63 as a UV-curable material for fabrication of microfluidic channels with native hydrophilicity

Microparticle photometry in a CMOS microsystem combining magnetic actuation and in-situ optical detection

On-Chip Sandwich Immunoassay in an Integrated Magneto-Optical CMOS Microsystem

Active superparamagnetic bead manipulation for immunoassays on-chip

On-chip detection of sandwich immunoassay in an integrated magneto-optical CMOS microsystem

Detection of fluorescently labelled magnetic particles for lab-on-a-chip applications

Detection of Fluorescently Labelled Magnetic Particles for Lab-on-a-chip Applications