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Freddy Radtke

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Publications associées (117)

Pharmacological disruption of the Notch transcription factor complex

Freddy Radtke, Rajwinder Lehal, Ute Koch, Nadine Fournier, Linlin Cao, Michele Vigolo, Jelena Zaric

Notch pathway signaling is implicated in several human cancers. Aberrant activation and mutations of Notch signaling components are linked to tumor initiation, maintenance, and resistance to cancer therapy. Several strategies, such as monoclonal antibodies ...

National Academy of Sciences2020

A third Notch in colorectal cancer progression and metastasis

Freddy Radtke, Ute Koch

In this issue of JEM, Varga et al. (https://doi.org/10.1084/jem.20191515) describe a mouse model of invasive and metastatic colorectal cancer (CRC) closely resembling the human consensus molecular subtype (CMS) 4 associated with the poorest overall surviva ...

ROCKEFELLER UNIV PRESS2020

Direct targeting of NOTCH transcription complex by a novel small molecule CB-103 circumvents dose-limiting toxicities associated with pan-NOTCH inhibitors

Freddy Radtke, Charlotte Marie Urech-Varenne, Rajwinder Lehal, Maximilien Murone, Michele Vigolo, Jelena Zaric

AMER ASSOC CANCER RESEARCH2019

Notch2 Signaling Maintains NSC Quiescence in the Murine Ventricular-Subventricular Zone

Freddy Radtke

Neurogenesis continues in the ventricular-subventricular zone (V-SVZ) of the adult forebrain from quiescent neural stem cells (NSCs). V-SVZ NSCs are a reservoir for new olfactory bulb (OB) neurons that migrate through the rostral migratory stream (RMS). To ...

2018

AMPK promotes survival of c-Myc-positive melanoma cells by suppressing oxidative stress

Friedrich Beermann, Freddy Radtke, Marzia Armaro, Ute Koch, Marion Leleu, Alain Kfoury

2018

Pharmacological activity of CB-103: An oral pan-NOTCH inhibitor targeting the NOTCH transcription complex

Freddy Radtke, Rajwinder Lehal, Maximilien Murone

Oxford University Press2018

Characterization and profiling of CB-103, a novel small-molecule protein-protein interaction inhibitor targeting the NOTCH transcription complex

Freddy Radtke, Charlotte Marie Urech-Varenne, Rajwinder Lehal, Maximilien Murone, Michele Vigolo

AMER ASSOC CANCER RESEARCH2018

Donor T Cells Require Notch Signals but Not Alloantigen Presentation from Specialized Secondary Lymphoid Organ Fibroblasts to Drive Graft-Versus-Host Disease

Freddy Radtke, Ute Koch

AMER SOC HEMATOLOGY2018

Notch as a tumour suppressor

Freddy Radtke, Craig Nowell

The Notch signalling cascade is an evolutionarily conserved pathway that has a crucial role in regulating development and homeostasis in various tissues. The cellular processes and events that it controls are diverse, and continued investigation over recen ...

Nature Publishing Group2017

Signalling strength determines proapoptotic functions of STING

Freddy Radtke, Ute Koch, Andrea Ablasser, Muhammet Fatih Gülen

Mammalian cells use cytosolic nucleic acid receptors to detect pathogens and other stress signals. In innate immune cells the presence of cytosolic DNA is sensed by the cGAS-STING signalling pathway, which initiates a gene expression programme linked to ce ...

Springer Nature2017

Pharmacological activity of CB-103: An oral pan-NOTCH inhibitor with a novel mode of action

Manuel Bauer, Freddy Radtke, Rajwinder Lehal, Maximilien Murone

Oxford Univ Press2017

Corneal epithelial stem cells and their niche at a glance

Freddy Radtke, Craig Nowell

The corneal epitheliumacts as a protective barrier on the anterior ocular surface and is essential for maintaining transparency of the cornea and thus visual acuity. During both homeostasis and repair, the corneal epithelium is maintained by self-renewing ...

Company Of Biologists Ltd2017

Pharmacological Activity Of Cb-103-An Oral Pan-Notch Inhibitor With A Novel Mode Of Action

Manuel Bauer, Freddy Radtke, Rajwinder Lehal, Maximilien Murone

Ferrata Storti Foundation2017

Linking inflammation and mechanotransduction in stem cell regulation

Freddy Radtke, Craig Nowell

Taylor & Francis Inc2016

Chronic inflammation imposes aberrant cell fate in regenerating epithelia through mechanotransduction

Matthias Lütolf, Yann Barrandon, Freddy Radtke, Craig Nowell, Sylke Höhnel, Georg Fantner, Pascal Damian Odermatt, Luca Azzolin

Chronic inflammation is associated with a variety of pathological conditions in epithelial tissues, including cancer, metaplasia and aberrant wound healing. In relation to this, a significant body of evidence suggests that aberration of epithelial stem and ...

Nature Publishing Group2016

Notch Signaling Regulates the Homeostasis of Tissue-Restricted Innate-like T Cells

Freddy Radtke, Ute Koch

Although Notch signaling plays important roles in lineage commitment and differentiation of multiple cell types including conventional T cells, nothing is currently known concerning Notch function in innate-like T cells. We have found that the homeostasis ...

American Association of Immunologists ; Oxford University Press2016

Development Of A Novel First-In-Class Oral Inhibitor Of The Notch Pathway

Gerardo Turcatti, Freddy Radtke, Rajwinder Lehal, Viktoria Reinmüller

Ferrata Storti Foundation2016

Dicer1 imparts essential survival cues in Notch-driven T-ALL via miR-21-mediated tumor suppressor Pdcd4 repression

Freddy Radtke, Ute Koch, Antoine Matthieu Chabloz, Fabian Junker

The modulatory function of individual microRNAs (miRNAs) in Notch-driven T-cell acute lymphoblastic leukemias (T-ALLs) has recently been established. Although protumorigenic and tumor-suppressive miRNAs are implicated in disease onset in murine models of N ...

American Society of Hematology2015

Phage Selection of Bicyclic Peptide Ligands of the Notch1 Receptor

Christian Heinis, Freddy Radtke, Charlotte Marie Urech-Varenne

Precise regulation of the Notch signaling pathway is crucial, as increases or deficiencies in signaling are associated with diseases, including a wide range of cancers. Recent studies have demonstrated that monoclonal antibodies that bind and stabilize the ...

Wiley-Blackwell2015

Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses

Nicolas Fasnacht, Freddy Radtke, Floriane Auderset, Ute Koch

Fibroblast-like cells of secondary lymphoid organs (SLO) are important for tissue architecture. In addition, they regulate lymphocyte compartmentalization through the secretion of chemokines, and participate in the orchestration of appropriate cell-cell in ...

Rockefeller University Press2014

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