Publications de Alexey Nazarov

Ruthenium(II)–arene and triruthenium-carbonyl cluster complexes with new water-soluble phopsphites based on glucose: Synthesis, characterization and antiproliferative activity

Paul Joseph Dyson, Alexey Nazarov, Olivier Pierre Zava

New water-soluble 3,5,6-bicyclophosphite ligands based on glucose modified with uracil, 5-fluorouracil or thymine are reported. The phosphite ligands were subsequently reacted with bis[dichlorido(η6-p-cymene)ruthenium(II)] and trirutheniumdodecacarbonyl to ...

2020

Understanding the interactions of diruthenium anticancer agents with amino acids

Paul Joseph Dyson, Christian Hartinger, Alexey Nazarov, Muhammad Hanif

The dinuclear anticancer agents 1,n-bis{chlorido3-(oxo-kappa O)-2-methyl-4-(1H)-pyridinonato-kappa O4-ruthenium(II)}alkane (PyRu2n) exhibit high antiproliferative activity in human cancer cell. Reactivity studies with DNA and protein rev ...

SPRINGER2018

New highly cytotoxic organic and organometallic bexarotene derivatives

Paul Joseph Dyson, Alexey Nazarov, Mathurin Baquié

A series of bifunctional ruthenium(II) arene compounds modified with bexarotene, a retinoid that selectively activates retinoid X receptors inducing cell differentiation and apoptosis and preventing drug resistance, are described. The bexarotene is tethere ...

Elsevier2017

Antiproliferative activity of ruthenium and osmium clusters with phosphine ligands

Paul Joseph Dyson, Alexey Nazarov

New ruthenium and osmium carbonyl clusters with 1,3,5-triaza-7-phosphatricyclo-[3.3.1.13.7]decane and 3,7-diacetyl-1,3,7-triaza-5-phosphabicyclo[3.3.1]nonane ligands were synthesized using Me3NO as an initiator. The data on antiproliferative activity of ne ...

Springer Verlag2016

Protein ruthenation and DNA alkylation: chlorambucil-functionalized RAPTA complexes and their anticancer activity

Paul Joseph Dyson, Christian Hartinger, Alexey Nazarov, Olivier Pierre Zava

Chemotherapeutics for the treatment of tumorigenic conditions that feature novel modes of action are highly sought after to overcome the limitations of current chemotherapies. Herein, we report the conjugation of the alkylating agent chlorambucil to the RA ...

2015

Ruthenium clusters as new class of anti-angiogenic agent

Hubert van den Bergh, Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Alexey Nazarov

Springer2014

Ligand substitutions between ruthenium-cymene compounds can control protein versus DNA targeting and anticancer activity

Paul Joseph Dyson, Ursula Röthlisberger, Wee Han Ang, Pablo Campomanes Ramos, Alexey Nazarov, Michael Groessl, Catherine Marie Amélie Clavel

Ruthenium compounds have become promising alternatives to platinum drugs by displaying specific activities against different cancers and favourable toxicity and clearance properties. Nonetheless, their molecular targeting and mechanism of action are poorly ...

Nature Research2014

Opening the lid on piano-stool complexes: An account of ruthenium(II)-arene complexes with medicinal applications

Paul Joseph Dyson, Christian Hartinger, Alexey Nazarov

Interest in the medicinal properties of ruthenium(II)-arene compounds has grown rapidly over the last decade. In this account we describe the origins of the field and subsequently highlight developments in the field, including the design of compounds that ...

Elsevier Science Sa2014

Multinuclear Cytotoxic Metallodrugs: Synthesis and Biological Studies of Novel Bimetallic Titanium-Ruthenium and Gold Complexes

Alexey Nazarov, Angela Casini, Michael Groessl, Olivier Pierre Zava

Springer2014

Organometallic anticancer agents that interfere with cellular energy processes: a subtle approach to inducing cancer cell death

Rosario Scopelliti, Paul Joseph Dyson, Daniel Gardini, Alexey Nazarov, Mathurin Baquié

Two hybrid compounds comprising an antimetastatic rutheniumarene fragment tethered to an indazole-3-carboxylic acid derivative that inhibits aerobic glycolysis in cancer cells have been prepared and evaluated in a variety of cancer cell lines, including hi ...

Royal Society of Chemistry2013

Synthesis and characterization of a new class of anti-angiogenic agent based on ruthenium clusters

Hubert van den Bergh, Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Alexey Nazarov, Michael Groessl, Olivier Pierre Zava, Mathurin Baquié

New triruthenium-carbonyl clusters derivatized with glucose-modified bicyclophosphite ligands have been synthesized. These compounds were found to have cytostatic and cytotoxic activity and depending on the number of bicyclophosphite ligands, and could be ...

Nature Publishing Group2013

Maleimide-functionalised organoruthenium anticancer agents and their binding to thiol-containing biomolecules

Paul Joseph Dyson, Yury Tsybin, Christian Hartinger, Alexey Nazarov, Michael Groessl, Muhammad Hanif

Ru-II(arene) anticancer compounds with maleimide functionality were prepared to allow selective interaction with thiol-containing biomolecules and thereby enforcing the selective delivery of the compounds to the tumour. ...

Royal Society of Chemistry2012

Synthesis of [Ru-II(eta(6)-p-cymene)(PPh3)(L)Cl]PF6 complexes with carbohydrate-derived phosphites, imidazole or indazole co-ligands

Christian Hartinger, Alexey Nazarov, Muhammad Hanif

Ru-II(arene) complexes of the general formula [Ru-II(eta(6)-p-cymene)(PPh3)(L)Cl]PF6 with L = P- or N-donor systems have been synthesized and characterized. Carbohydrate-derived phosphites, imidazole or indazole have been chosen as co-ligands and different ...

Elsevier2012

Anthracene-Tethered Ruthenium(II) Arene Complexes as Tools To Visualize the Cellular Localization of Putative Organometallic Anticancer Compounds

Rosario Scopelliti, Paul Joseph Dyson, Wee Han Ang, Julie Risse, Christian Hartinger, Alexey Nazarov, Michael Groessl, Olivier Pierre Zava, Albert Ruggi, Frédéric Schmitt

Anthracene derivatives of ruthenium(II) arene compounds with 1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane (pta) or a sugar phosphite ligand, viz., 3,5,6-bicyclophosphite1,2-O-isopropylidene-alpha-D-glucofuranoside, were prepared in order to evaluate their ...

2012

Organometallic Ruthenium(II) Arene Compounds with Antiangiogenic Activity

Hubert van den Bergh, Georges Wagnières, Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Alexey Nazarov, Angela Casini

The antimetastatic ruthenium (II) compounds [Ru(eta(6)-p-cymene)Cl-2(PTA)] (PTA = 1,3,5-triaza-7-phosphaadamantane) (RAPTA-C) and [Ru(eta(6)-toluene)Cl-2(PTA)] (RAPTA-T), as well as their analogues [Ru(eta(6)-p-cymene)Cl-2(DAPTA)] (DAPTA = (3,7-diacetyl-1, ...

2011

Specific DNA structural attributes modulate platinum anticancer drug site selection and cross-link generation

Paul Joseph Dyson, Alexey Nazarov

Heavy metal compounds have toxic and medicinal potential through capacity to form strong specific bonds with macromolecules, and the interaction of platinum drugs at the major groove nitrogen atom of guanine bases primarily underlies their therapeutic acti ...

Oxford University Press2011

Polynuclear Ruthenium, Osmium and Gold Complexes. The Quest for Innovative Anticancer Chemotherapeutics

Andrew Douglas Phillips, Christian Hartinger, Alexey Nazarov

Polynuclear compounds are a relatively new and successful approach in metal-based cancer chemotherapy as typified by the trinuclear Pt compound BBR3464 which was evaluated in clinical trials. In this review, we discuss newer developments of polynuclear rut ...

2011

DNA Reactivity Profile of trans-Platinum Planar Amine Derivatives

Alexey Nazarov

New trans-platinum planar amines (TPAs) represent a family of platinum-based drugs with cytotoxicity equivalent to that of cisplatin, but with negligible cross-resistance. According to the substitution pattern around the metal center, distinct DNA adducts ...

2011

Thermoresponsive Chlorambucil Derivatives for Tumour Targeting

Paul Joseph Dyson, Alexey Nazarov, Olivier Pierre Zava, Catherine Marie Amélie Clavel, Frédéric Schmitt

Wiley-VCH Verlag GmbH2011

Mannich products of kojic acid and N-heterocycles and their Ru(II)-arene complexes: Synthesis, characterization and stability

Paul Joseph Dyson, Christian Hartinger, Alexey Nazarov

Ru(II)-η6-p-cymene compds. bearing pyrone-derived ligands, which were obtained by Mannich reactions between kojic acid and piperidine or morpholine analogs, have been synthesized. The compds. were characterized by NMR spectroscopy, mass spectrometry, therm ...

Elsevier2010