Publications de Qingxia Zhong | EPFL Graph Search

Experimental adaptation of human echovirus 11 to ultraviolet radiation leads to tolerance to disinfection and resistance to ribavirin

Virginie Bachmann, Tamar Kohn, Hyunjin Shim, Qingxia Zhong, Jeffrey David Jensen, Anna Carratala Ripolles

Ultraviolet light in the UVC range is a commonly used disinfectant to control viruses in clinical settings and water treatment. Here, we employed an experimental evolution approach to investigate the adaptation of human echovirus 11 to disinfection by UVC, ...

2017

Resistance of echovirus 11 to ClO2 is associated with enhanced host receptor use, altered entry routes and high fitness

Virginie Bachmann, Tamar Kohn, Hyunjin Shim, Qingxia Zhong, Jeffrey David Jensen, Anna Carratala Ripolles

Waterborne viruses can exhibit resistance to common water disinfectants, yet the mechanisms that allow them to tolerate disinfection are poorly understood. Here, we generated echovirus 11 (E11) with resistance to chlorine dioxide (ClO2) by experimental evo ...

Amer Chemical Soc2017

Cross-resistance of UV- or chlorine dioxide-resistant echovirus 11 to other disinfectants

Virginie Bachmann, Tamar Kohn, Qingxia Zhong, Anna Carratala Ripolles, Rachele Ossola

The emergence of waterborne viruses with resistance to disinfection has been demonstrated in the laboratory and in the environment. Yet, the implications of such resistance for virus control remain obscure. In this study we investigate if viruses with resi ...

Frontiers Media SA2017

Genotypic, phenotypic and mechanistic insights into viruses with resistance to common water disinfectants

Qingxia Zhong

Infectious diseases caused by waterborne viruses contribute to the global disease burden. An effective barrier to prevent the discharge of waterborne viruses is a disinfection step, yet disinfection is not always efficient at inactivating viruses. This the ...

EPFL2017

Genetic, structural and phenotypic properties of MS2 coliphage with resistance to ClO2 disinfection

Virginie Bachmann, Tamar Kohn, Qingxia Zhong, Petr Leiman, Sergey Nazarov, Anna Carratala Ripolles, Laura Piccinini, Ricardo Cesar Guerrero Ferreira

Common water disinfectants like chlorine have been reported to select for resistant viruses, yet little attention has been devoted to characterizing disinfection resistance. Here, we investigated the resistance of MS2 coliphage to inactivation by chlorine ...

Amer Chemical Soc2016

On the cause of the tailing phenomenon during virus disinfection by chlorine dioxide

Anne Thérèse Sigstam, Tamar Kohn, Moritz Brennecke, Qingxia Zhong, Andreas Rohatschek

This study investigates the mechanisms underlying the deviation from Chick-Watson kinetics, namely a tailing curve, during the disinfection of viruses by chlorine dioxide (ClO2). Tailing has been previously reported, but is typically attributed to the deca ...

Elsevier2014