Publications de Jocelin Grosse

Urolithin A abolishes high anxiety and rescues the associated mitochondria-related transcriptomic signatures and synaptic function

Maria del Carmen Sandi Perez, Olivia Zanoletti, Jocelin Grosse, Marie-Isabelle Guillot de Suduiraut, Dogukan Hazar Ülgen, Davide D'Amico, Simone Astori

Background: Chronic anxiety is common, disabling, and often refractory to current therapies. Mounting evidence implicates mitochondrial abnormalities in anxiety-related phenotypes. Urolithin A (UA), a gut microbiota-derived metabolite known to enhance mito ...

Elsevier BV2025

Mitofusin-2 in nucleus accumbens D2-MSNs regulates social dominance and neuronal function

Bernard Schneider, Maria del Carmen Sandi Perez, Olivia Zanoletti, Jocelin Grosse, Elias Georges Gebara, Marie-Isabelle Guillot de Suduiraut, Simone Astori, Sriparna Ghosal, Eva Ramos Fernandez, Alessandro Chioino

The nucleus accumbens (NAc) is a brain hub regulating motivated behaviors, including social competitiveness. Mitochondrial function in the NAc links anxiety with social competitiveness, and the mitochondrial fusion protein mitofusin 2 (Mfn2) in NAc neurons ...

2023

Blunted Glucocorticoid Responsiveness to Stress Causes Behavioral and Biological Alterations That Lead to Posttraumatic Stress Disorder Vulnerability

Maria del Carmen Sandi Perez, Olivia Zanoletti, Jocelin Grosse, Sophie Elizabeth Walker, Marie-Isabelle Guillot de Suduiraut, Simone Astori, Silvia Monari

Background: Understanding why only a subset of trauma-exposed individuals develop posttraumatic stress disorder is critical for advancing clinical strategies. A few behavioral (deficits in fear extinction) and biological (blunted glucocorticoid levels, sma ...

2023

Deletion of Crtc1 leads to hippocampal neuroenergetic impairments associated with depressive-like behavior

Bernard Lanz, Maria del Carmen Sandi Perez, Rolf Gruetter, Carole Poitry-Yamate, Antoine Timothée Cherix, Olivia Zanoletti, Jocelin Grosse

Mood disorders (MD) are a major burden on society as their biology remains poorly understood, challenging both diagnosis and therapy. Among many observed biological dysfunctions, homeostatic dysregulation, such as metabolic syndrome (MeS), shows considerab ...

SPRINGERNATURE2022

Creatine transporter-deficient rat model shows motor dysfunction, cerebellar alterations, and muscle creatine deficiency without muscle atrophy

Maria del Carmen Sandi Perez, Jocelin Grosse

Creatine (Cr) is a nitrogenous organic acid and plays roles such as fast phosphate energy buffer to replenish ATP, osmolyte, antioxidant, neuromodulator, and as a compound with anabolic and ergogenic properties in muscle. Cr is taken from the diet or endog ...

WILEY2022

Opposite effects of stress on effortful motivation in high and low anxiety are mediated by CRHR1 in the VTA

Maria del Carmen Sandi Perez, Olivia Zanoletti, Jocelin Grosse, Marie-Isabelle Guillot de Suduiraut, Ioannis Zalachoras, Simone Astori, Mandy Meijer

Individuals frequently differ in their behavioral and cognitive responses to stress. However, whether motivation is differently affected by acute stress in different individuals remains to be established. By exploiting natural variation in trait anxiety in ...

2022

eNAMPT actions through nucleus accumbens NAD + /SIRT1 link increased adiposity with sociability deficits programmed by peripuberty stress

Maria del Carmen Sandi Perez, Johan Auwerx, Olivia Zanoletti, Jocelin Grosse, Marie-Isabelle Guillot de Suduiraut, Wei Huang, Laia Morato Fornaguera, Ioannis Zalachoras, Simone Astori, João Pedro de Matos Rodrigues, Sriparna Ghosal, Lei Cao

Obesity is frequently associated with impairments in the social domain, and stress at puberty can lead to long-lasting changes in visceral fat deposition and in social behaviors. However, whether stress-induced changes in adipose tissue can affect fat-to-b ...

2022

A new rat model of creatine transporter deficiency reveals behavioral disorder and altered brain metabolism

Maria del Carmen Sandi Perez, Cristina Ramona Cudalbu, Jocelin Grosse, Dunja Simicic

Creatine is an organic compound used as fast phosphate energy buffer to recycle ATP, important in tissues with high energy demand such as muscle or brain. Creatine is taken from the diet or endogenously synthetized by the enzymes AGAT and GAMT, and specifi ...

Nature Research2021

Probiotics improve the neurometabolic profile of rats with chronic cholestatic liver disease

Cristina Ramona Cudalbu, Jocelin Grosse, Emmanuelle Ines Flatt, Veronika Rackayová

Chronic liver disease leads to neuropsychiatric complications called hepatic encephalopathy (HE). Current treatments have some limitations in their efficacy and tolerability, emphasizing the need for alternative therapies. Modulation of gut bacterial flora ...

Nature Research2021

Metabolic signature in nucleus accumbens for anti-depressant-like effects of acetyl-L-carnitine

Maria del Carmen Sandi Perez, Rolf Gruetter, Antoine Timothée Cherix, Jocelin Grosse, Thomas Didier Larrieu, João Pedro de Matos Rodrigues

Emerging evidence suggests that hierarchical status provide vulnerability to develop stress-induced depression. Energy metabolic changes in the nucleus accumbens (NAc) were recently related to hierarchical status and vulnerability to develop depression-lik ...

2020

Mitochondrial gene signature in the prefrontal cortex for differential susceptibility to chronic stress

Maria del Carmen Sandi Perez, Rolf Gruetter, Bart Deplancke, Antoine Timothée Cherix, Jocelin Grosse, Julie Marie Russeil, Daniel Alpern, Meltem Weger, Sriparna Ghosal

Mitochondrial dysfunction was highlighted as a crucial vulnerability factor for the development of depression. However, systemic studies assessing stress-induced changes in mitochondria-associated genes in brain regions relevant to depression symptomatolog ...

2020

The glucocorticoid receptor in the nucleus accumbens plays a crucial role in social rank attainment in rodents

Maria del Carmen Sandi Perez, Olivia Zanoletti, Jocelin Grosse, Fiona Hollis, Alexandre Claude Gustave Bacq, Ioannis Zalachoras, Thomas Didier Larrieu, Meltem Weger

Social hierarchy in social species is usually established through competitive encounters with conspecifics. It determines the access to limited resources and, thus, leads to reduced fights among individuals within a group. Despite the known importance of s ...

2020

Astrocytic release of ATP through type 2 inositol 1,4,5‐trisphosphate receptor calcium signaling and social dominance behavior in mice

Maria del Carmen Sandi Perez, Jocelin Grosse, Fiona Hollis, Marie-Isabelle Guillot de Suduiraut, Eva Ramos Fernandez

Brain mitochondrial function is critical for numerous neuronal processes. We recently identified a link between brain energy and social dominance, where higher levels of mitochondrial function resulted in increased social competitive ability. The underlyin ...

2020

Low vagal tone in two rat models of psychopathology involving high or low corticosterone stress responses

Maria del Carmen Sandi Perez, Damien Sébastien Huzard, Jocelin Grosse, Sriparna Ghosal

The two stress-responsive physiological systems, autonomic nervous system (ANS) and hypothalamus-pituitary-adrenal (HPA) axis exert complementary and interrelated actions in the organism. Individuals that suffer stress-related psychopathologies frequently ...

2019

Peripubertal stress-induced heightened aggression: modulation of the glucocorticoid receptor in the central amygdala and normalization by mifepristone treatment

Maria del Carmen Sandi Perez, Stamatina Tzanoulinou, Vandana Veenit, Olivia Zanoletti, Jocelin Grosse, Orbicia Riccio Wicht

Despite the enormous negative impact of excessive aggression for individuals and societies, there is a paucity of treatments. Here, using a peripubertal stress model of heightened aggression in rats, we investigated the involvement of the glucocorticoid sy ...

2019

Longitudinal neurometabolic changes in the hippocampus of a rat model of chronic hepatic encephalopathy

Katarzyna Pierzchala, Cristina Ramona Cudalbu, Jocelin Grosse, Veronika Rackayová

Background & Aims: The sequence of events in hepatic encephalopathy (HE) remains unclear. Using the advantages of in vivo 1H-MRS (9.4T) we aimed to analyse the time-course of disease in an established model of type C HE by analysing the longitudinal change ...

2019

Diazepam actions in the VTA enhance social dominance and mitochondrial function in the nucleus accumbens by activation of accumbal dopamine D1 receptors

Maria del Carmen Sandi Perez, Carlos Canto Alvarez, Olivia Zanoletti, Jocelin Grosse, Michael van der Kooij, Fiona Hollis, Laura Lozano Montes, Marie-Isabelle Guillot de Suduiraut, Ioannis Zalachoras, Sonia Abad Florensa

Benzodiazepines can ameliorate social disturbances and increase social competition, particularly in high-anxious individuals. However, the neural circuits and mechanisms underlying benzodiazepines’ effects in social competition are not understood. Convergi ...

Nature Publishing Group2018

Increased brain glucocorticoid actions following social defeat in rats facilitates the long-term establishment of social subordination

Maria del Carmen Sandi Perez, Olivia Zanoletti, Jocelin Grosse, Meltem Weger

Social rank is frequently established through aggressive encounters between new conspecifics. Despite increasing evidence suggesting that social rank is critical for the well-being of both humans and animals, knowledge about the factors influencing social ...

2018

Peripubertal stress increases play fighting at adolescence and modulates nucleus accumbens CB1 receptor expression and mitochondrial function in the amygdala

Maria del Carmen Sandi Perez, Olivia Zanoletti, Jocelin Grosse

Play fighting is a highly rewarding behavior that helps individuals to develop social skills. Early-life stress has been shown to alter play fighting in rats and hamsters as well as to increase aggressive behaviors at adulthood. However, it is not known wh ...

2018

Amygdala GluN2B-NMDAR dysfunction is critical in abnormal aggression of neurodevelopmental origin induced by St8sia2 deficiency

Graham Knott, Maria del Carmen Sandi Perez, Olivia Zanoletti, Jocelin Grosse, Elias Georges Gebara, Wei Tang, Alexandre Claude Gustave Bacq, Johannes Gräff, Catherine Maclachlan, Jose Vicente Sanchez Mut, Bianca Ambrogina Silva, Simone Astori

Aggression is frequently observed in neurodevelopmental psychiatric disorders such as schizophrenia, autism, and bipolar disorder. Due to a lack of understanding of its underlying mechanisms, effective treatments for abnormal aggression are still missing. ...

2020