Publications de Fernando Romero Balestra

Sperm-contributed centrioles segregate stochastically into blastomeres of 4-cell stage Caenorhabditis elegans embryos

Whereas both sperm and egg contribute nuclear genetic material to the zygote in metazoan organisms, the inheritance of other cellular constituents is unequal between the 2 gametes. Thus, 2 copies of the centriole are contributed solely by the sperm to the ...

GENETICS SOCIETY AMERICA2023

TRIM37 prevents formation of centriolar protein assemblies by regulating Centrobin

Pierre Gönczy, Coralie Busso, Fernando Romero Balestra, Benita Wolf, Tessa Vivianne Averink, Alizée Buff

TRIM37 is an E3 ubiquitin ligase mutated in Mulibrey nanism, a disease with impaired organ growth and increased tumor formation. TRIM37 depletion from tissue culture cells results in supernumerary foci bearing the centriolar protein Centrin. Here, we chara ...

2021

ZYG-1 promotes limited centriole amplification in the C. elegans seam lineage

Pierre Gönczy, Fernando Romero Balestra, Benita Wolf, Antoine Jérôme Spahr

2018

Paternally contributed centrioles exhibit exceptional persistence in C-elegans embryos

Pierre Gönczy, Lukas von Tobel, Fernando Romero Balestra

Inst Biochemistry & Cell Biology2015

Multiciliogenesis: multicilin directs transcriptional activation of centriole formation

Pierre Gönczy, Fernando Romero Balestra

During differentiation of multiciliated cells, numerous centrioles are generated in each cell to act as templates for the formation of a corresponding number of cilia. A new study reveals that multicilin, a protein required for multiciliogenesis, is a key ...

Cell Press2014

Discovering Regulators of Centriole Biogenesis through siRNA-Based Functional Genomics in Human Cells

Pierre Gönczy, Petr Strnad, Isabelle Fluckiger, Fernando Romero Balestra

Centrioles are essential for forming cilia, flagella, and centrosomes and are thus critical for a range of fundamental cellular processes. Despite their importance, the mechanisms governing centriole biogenesis remain incompletely understood. We performed ...

Cell Press - Elsevier2013

Discovering Regulators of Centriole Biogenesis through siRNA-Based Functional Genomics in Human Cells

Fernando Romero Balestra

Centrioles are essential for forming cilia, flagella, and centrosomes and are thus critical for a range of fundamental cellular processes. Despite their importance, the mechanisms governing centriole biogenesis remain incompletely understood. We performed ...

EPFL Infoscience2013

Spindle positioning in human cells relies on proper centriole formation and on the microcephaly proteins CPAP and STIL

Pierre Gönczy, Debora Keller, Gregor Kohlmaier, Petr Strnad, Fernando Romero Balestra

Patients with MCPH (autosomal recessive primary microcephaly) exhibit impaired brain development, presumably due to the compromised function of neuronal progenitors. Seven MCPH loci have been identified, including one that encodes centrosome protein 4.1 as ...

Company of Biologists2011