Publications de Benjamin John Marsland

Infection with a small intestinal helminth, Heligmosomoides polygyrus bakeri, consistently alters microbial communities throughout the murine small and large intestine

Alexis Rapin, Luc Xavier Marie Lebon, Nicola Harris, Benjamin John Marsland, Mario Michael Zaiss, Audrey Geneviève Chuat

Increasing evidence suggests that intestinal helminth infection can alter intestinal microbial communities with important impacts on the mammalian host. However, all of the studies to date utilize different techniques to study the microbiome and access dif ...

2020

Dietary Fiber Confers Protection against Flu by Shaping Ly6c(-) Patrolling Monocyte Hematopoiesis and CD8(+) T Cell Metabolism

Céline Pattaroni, Benjamin John Marsland, Eva Sabrina Gollwitzer

2018

Enteric helminth-induced type I interferon signaling protects against pulmonary virus infection through interaction with the microbiota

Nicola Harris, Benjamin John Marsland, Eva Sabrina Gollwitzer

BACKGROUND: Helminth parasites have been reported to have beneficial immunomodulatory effects in patients with allergic and autoimmune conditions and detrimental consequences in patients with tuberculosis and some viral infections. Their role in coinfectio ...

Elsevier2017

Microbiota Analysis Using an Illumina MiSeq Platform to Sequence 16S rRNA Genes

Alexis Rapin, Céline Pattaroni, Nicola Harris, Benjamin John Marsland

The microbiota have been shown to play an important role in diverse biological processes including immunity, metabolism, and digestion. Assessing the exact composition of the microbiota has proven challenging due to the often unknown growth specificities o ...

2017

Immune Antibodies and Helminth Products Drive CXCR2-Dependent Macrophage-Myofibroblast Crosstalk to Promote Intestinal Repair

Jérôme Bürgi, Nicola Harris, Benjamin John Marsland, Julia Esser-von Bieren, Beatrice Volpe, Duncan-Bruce Sutherland

Helminth parasites can cause considerable damage when migrating through host tissues, thus making rapid tissue repair imperative to prevent bleeding and bacterial dissemination particularly during enteric infection. However, how protective type 2 responses ...

Public Library Science2015

The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation

Alexis Rapin, Jacques Rougemont, Laure Menin, Luc Xavier Marie Lebon, Ilaria Mosconi, Nicola Harris, Benjamin John Marsland, Mario Michael Zaiss, Lalit Kumar Dubey, Alessandra Piersigilli, Andrew J. Macpherson

Intestinal helminths are potent regulators of their host's immune system and can ameliorate inflammatory diseases such as allergic asthma. In the present study we have assessed whether this anti-inflammatory activity was purely intrinsic to helminths, or w ...

Elsevier2015

Antibody-Mediated Trapping of Helminth Larvae Requires CD11b and Fc gamma Receptor I

Manuel Kulagin, Arne Seitz, Nicola Harris, Benjamin John Marsland, Julia Esser-von Bieren, Romain Guiet, Beatrice Volpe, Duncan-Bruce Sutherland

Infections with intestinal helminths severely impact on human and veterinary health, particularly through the damage that these large parasites inflict when migrating through host tissues. Host immunity often targets the motility of tissue-migrating helmin ...

American Association of Immunologists ; Oxford University Press2015

Nanoparticle conjugation enhances the immunomodulatory effects of intranasally delivered CpG in house dust mite-allergic mice

Jeffrey Alan Hubbell, Melody Swartz, Alexandre de Titta, Marie Ballester, Laura Jeanbart, Benjamin John Marsland

An emerging strategy in preventing and treating airway allergy consists of modulating the immune response induced against allergens in the lungs. CpG oligodeoxynucleotides have been investigated in airway allergy studies, but even if promising, efficacy re ...

Nature Publishing Group2015

Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis

Nicola Harris, Benjamin John Marsland, Eva Sabrina Gollwitzer

Metabolites from intestinal microbiota are key determinants of host-microbe mutualism and, consequently, the health or disease of the intestinal tract. However, whether such host-microbe crosstalk influences inflammation in peripheral tissues, such as the ...

Nature Publishing Group2014

Thymic stromal lymphopoietin plays divergent roles in murine models of atopic and nonatopic airway inflammation

Ilaria Mosconi, Nicola Harris, Benjamin John Marsland

BackgroundThymic stromal lymphopoietin (TSLP) is a cytokine primarily produced by epithelial cells, which has been shown to be a potent inducer of T-helper 2 (Th2)-type responses. However, TSLP has pleiotropic effects upon immune cells, and although extens ...

Wiley-Blackwell2014

IL-1β Suppresses Innate IL-25 and IL-33 Production and Maintains Helminth Chronicity

Nadine Guenat, Ilaria Mosconi, Nicola Harris, Benjamin John Marsland, Mario Michael Zaiss

Approximately 2 billion people currently suffer from intestinal helminth infections, which are typically chronic in nature and result in growth retardation, vitamin A deficiency, anemia and poor cognitive function. Such chronicity results from co-evolution ...

Public Library Science2013

TSLP promotes influenza-specific CD8+ T-cell responses by augmenting local inflammatory dendritic cell function

Nicola Harris, Benjamin John Marsland

Thymic stromal lymphopoietin (TSLP) is a mucosal tissue-associated cytokine that has been widely studied in the context of T helper type 2 (Th2)-driven inflammatory disorders. Although TSLP is also produced upon viral infection in vitro, the role of TSLP i ...

Nature Publishing Group2013

Dysregulation of Allergic Airway Inflammation in the Absence of Microbial Colonization

Nicola Harris, Tina Herbst, Benjamin John Marsland

RATIONALE: The incidence of allergic disorders is increasing in developed countries and has been associated with reduced exposure to microbes and alterations in the commensal bacterial flora. OBJECTIVES: To ascertain the relevance of commensal bacteria upo ...

2011

Nanoparticle conjugation of antigen enhances cytotoxic T-cell responses in pulmonary vaccination

Jeffrey Alan Hubbell, Melody Swartz, Marie Ballester, Armando Stano, Karen Dane, Benjamin John Marsland

The ability of vaccines to induce memory cytotoxic T-cell responses in the lung is crucial in stemming and treating pulmonary diseases caused by viruses and bacteria. However, most approaches to subunit vaccines produce primarily humoral and only to a less ...

National Academy of Sciences2011