Publications de Julia Esser-von Bieren

beta-Glucan receptors on IL-4 activated macrophages are required for hookworm larvae recognition and trapping

Nicola Harris, Julia Esser-von Bieren, Beatrice Volpe, Tiffany Babette Angélique Bouchery, Mati André Marie Moyat

Recent advances in the field of host immunity against parasitic nematodes have revealed the importance of macrophages in trapping tissue migratory larvae. Protective immune mechanisms against the rodent hookworm Nippostrongylus brasiliensis (Nb) are mediat ...

WILEY2022

Acetate, a metabolic product of Heligmosomoides polygyrus, facilitates intestinal epithelial barrier breakdown in a FFAR2-dependent manner

Luc Xavier Marie Lebon, Nicola Harris, Mario Michael Zaiss, Julia Esser-von Bieren, Lalit Kumar Dubey

Approximately 2 billion people worldwide and a significant part of the domestic livestock are infected with soil-transmitted helminths, of which many establish chronic infections causing substantial eco-nomic and welfare burdens. Beside intensive research ...

2022

Immune serum-activated human macrophages coordinate with eosinophils to immobilize Ascaris suum larvae

Nicola Harris, Julia Esser-von Bieren, Beatrice Volpe, Kathleen Shah, Tiffany Babette Angélique Bouchery

Helminth infection represents a major health problem causing approximately 5 million disability-adjusted life years worldwide. Concerns that repeated anti-helminthic treatment may lead to drug resistance render it important that vaccines are developed but ...

WILEY2020

House dust mite drives proinflammatory eicosanoid reprogramming and macrophage effector functions

Nicola Harris, Julia Esser-von Bieren, Tiffany Babette Angélique Bouchery

Background Eicosanoid lipid mediators play key roles in type 2 immune responses, for example in allergy and asthma. Macrophages represent major producers of eicosanoids and they are key effector cells of type 2 immunity. We aimed to comprehensively track e ...

WILEY2019

A parasitic immunomodulator reprograms the arachidonic acid metabolism of macrophages via a p38 map kinase-dependent pathway

Nicola Harris, Julia Esser-von Bieren

2018

Helminth products limit type 2 inflammation by directly suppressing granulocyte activation

Nicola Harris, Julia Esser-von Bieren

2018

Concerted Activity of IgG1 Antibodies and IL-4/IL-25-Dependent Effector Cells Trap Helminth Larvae in the Tissues following Vaccination with Defined Secreted Antigens, Providing Sterile Immunity to Challenge Infection

Nicola Harris, Julia Esser-von Bieren

Over 25% of the world's population are infected with helminth parasites, the majority of which colonise the gastrointestinal tract. However, no vaccine is yet available for human use, and mechanisms of protective immunity remain unclear. In the mouse model ...

Public Library of Science2015

Immune Antibodies and Helminth Products Drive CXCR2-Dependent Macrophage-Myofibroblast Crosstalk to Promote Intestinal Repair

Jérôme Bürgi, Nicola Harris, Benjamin John Marsland, Julia Esser-von Bieren, Beatrice Volpe, Duncan-Bruce Sutherland

Helminth parasites can cause considerable damage when migrating through host tissues, thus making rapid tissue repair imperative to prevent bleeding and bacterial dissemination particularly during enteric infection. However, how protective type 2 responses ...

Public Library Science2015

Antibody-Mediated Trapping of Helminth Larvae Requires CD11b and Fc gamma Receptor I

Manuel Kulagin, Arne Seitz, Nicola Harris, Benjamin John Marsland, Julia Esser-von Bieren, Romain Guiet, Beatrice Volpe, Duncan-Bruce Sutherland

Infections with intestinal helminths severely impact on human and veterinary health, particularly through the damage that these large parasites inflict when migrating through host tissues. Host immunity often targets the motility of tissue-migrating helmin ...

American Association of Immunologists ; Oxford University Press2015

Parasite Proximity Drives the Expansion of Regulatory T Cells in Peyer's Patches following Intestinal Helminth Infection

Luc Xavier Marie Lebon, Ilaria Mosconi, Nicola Harris, Mario Michael Zaiss, Julia Esser-von Bieren, Beatrice Volpe, Lalit Kumar Dubey

Helminth infections are typically chronic in nature; however, the exact molecular mechanisms by which these parasites promote or thwart host immunity remain unclear. Worm expulsion requires the differentiation of CD4(+) T cells into Th2 cells, while regula ...

American Society for Microbiology2015

Antibodies Trap Tissue Migrating Helminth Larvae and Prevent Tissue Damage by Driving IL-4Rα-Independent Alternative Differentiation of Macrophages

Fei Chen, Arne Seitz, Ilaria Mosconi, Nicola Harris, Julia Esser-von Bieren, Romain Guiet, Beatrice Volpe, Alessandra Piersigilli

Approximately one-third of the world's population suffers from chronic helminth infections with no effective vaccines currently available. Antibodies and alternatively activated macrophages (AAM) form crucial components of protective immunity against chall ...

Public Library of Science2013

Antibodies and IL-3 support helminth-induced basophil expansion

Manuel Kulagin, Nicola Harris, Tina Herbst, Mario Michael Zaiss, Julia Esser-von Bieren

Basophils are powerful mediators of Th2 immunity and are present in increased numbers during allergic inflammation and helminth infection. Despite their ability to potentiate Th2 immunity the mechanisms regulating basophil development remain largely unknow ...

National Academy of Sciences2012