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Grégoire Courtine

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Publications associées (147)

Confronting false discoveries in single-cell differential expression

Grégoire Courtine, Quentin Barraud, Mark Andrew Anderson, Claudia Kathe, Nicholas David James, Jordan Squair, Matthieu Pierre Gautier, Gioele La Manno, Thomas Haynes Hutson, Rémi Bernard René Hudelle, Michael Alexander Skinnider

Differential expression analysis of single-cell transcriptomics allows scientists to dissect cell-type-specific responses to biological perturbations. Here, the authors show that many commonly used methods are biased and can produce false discoveries. ...

Nature Portfolio2021

Neglected physical human-robot interaction may explain variable outcomes in gait neurorehabilitation research

Grégoire Courtine

During gait neurorehabilitation, many factors influence the quality of gait patterns, particularly the chosen body-weight support (BWS) device. Consequently, robotic BWS devices play a key role in gait rehabilitation of people with neurological disorders. ...

AMER ASSOC ADVANCEMENT SCIENCE2021

A system for providing neuromodulation, especially neurostimulation

Grégoire Courtine, Marco Capogrosso, Beatrice Barra, Katie Zhi Zhuang

A system (10) for providing neuromodulation, especially neurostimulation, comprising - at least one neuromodulator (12) for neuromodulation of the cervical spinal cord, - at least one dorsal neuromodulation array (14) for providing neuromodulation to the c ...

2020

Ultralong, complexly structured micro- and nanoscale metallic glasses and fibers

Inès Richard, Grégoire Courtine, Fabien Sorin, Wei Yan

The present invention and its embodiments propose a simple, unique, and scalable method for producing extremely long, highly uniform, and well-ordered micro- and nanoscale metallic glasses via thermal drawing the method comprising at least the steps of pre ...

2020

Soft, Implantable Bioelectronic Interfaces for Translational Research

Sébastien Jiguet, Giuseppe Schiavone, Nicolas Vachicouras, Florian Dylan Fallegger, Stéphanie Lacour, Grégoire Courtine, Marco Capogrosso, Evgenia Vladimirova Roussinova, Ivan Furfaro, Andreas Rowald, Beatrice Barra, Simon Borgognon, Jocelyne Bloch, Xiaoyang Kang, Ismael Seanez Gonzalez

The convergence of materials science, electronics, and biology, namely bioelectronic interfaces, leads novel and precise communication with biological tissue, particularly with the nervous system. However, the translation of lab‐based innovation toward cli ...

Wiley2020

Guidelines to Study and Develop Soft Electrode Systems for Neural Stimulation

Jérôme Gandar, Giuseppe Schiavone, Florian Dylan Fallegger, Stéphanie Lacour, Grégoire Courtine, Xiaoyang Kang

2020

System for closed loop control of autonomic function

Grégoire Courtine, Jordan Squair

A neuromodulation system (10,110) is disclosed, especially a neurostimulation system (10,110), for treating a patient, especially for enhancing at least one autonomous function such a blood circulation and/or respiration, wherein the system comprises • - a ...

2020

Low-Dimensional Motor Cortex Dynamics Preserve Kinematics Information During Unconstrained Locomotion in Nonhuman Primates (vol

Mehdi Aghagolzadeh, Grégoire Courtine, David Allenson Borton

FRONTIERS MEDIA SA2020

Structured nanoscale metallic glass fibres with extreme aspect ratios

Giuseppe Schiavone, Güven Kurtuldu, Inès Richard, Stéphanie Lacour, Grégoire Courtine, Dang Tùng Nguyen, Fabien Sorin, Wei Yan, Yunpeng Qu, Vasiliki Tileli, Nicholas David James, Jordan Squair, Reinis Ignatans

Micro- and nanoscale metallic glasses offer exciting opportunities for both fundamental research and applications in healthcare, micro-engineering, optics and electronics. The scientific and technological challenges associated with the fabrication and util ...

Nature Publishing Group2020

System and method for control of autonomic function

Grégoire Courtine, Jordan Squair

A system (10) for neuromodulation and/or neurostimulation, for the treatment of a mammal, at least comprising: - at least one control unit (12) configured and arranged to provide stimulation data; - at least one stimulation unit (14) configured and arrange ...

2020

Soft Printable Electrode Coating for Neural Interfaces

Florian Dylan Fallegger, Elvira Pirondini, Stéphanie Lacour, Arnaud Bichat, Grégoire Courtine, Quentin Barraud, Michael Shur

The mechanical mismatch between implantable interfaces and neural tissues may be reduced by employing soft polymeric materials. Here, we report on a simple strategy to prepare and pattern a soft electrode coating of neural interfacing devices based on a sc ...

2020

Automatic clustering of spinal reflexes evoked by epidural electrical stimulation of the cervical spinal cord in non-human primates

Giuseppe Schiavone, Stéphanie Lacour, Grégoire Courtine, Marco Capogrosso, Sara Conti, Beatrice Barra, Katie Zhi Zhuang, Jocelyne Bloch

Epidural electrical stimulation of the spinal cord elicits motor responses by recruiting large sensory afferents in the posterior roots. Divergence of excitatory inputs provided by these fibers generates a variety of shapes, latencies and amplitudes in the ...

2019

Transcriptional Dynamics Of Neurorehabilitation In Spinal Cord Injury At Single-Nucleus Resolution

Grégoire Courtine, Laetitia Danielle Philippine Baud, Claudia Kathe, Jordan Squair, Michael Alexander Skinnider

MARY ANN LIEBERT, INC2019

A system for planning and/or providing neuromodulation

Vincent Delattre, Grégoire Courtine, Marco Capogrosso, Fabien Bertrand Paul Wagner, Karen Minassian

The present invention relates to a system for planning and/or providing neuromodulation (10), especially neurostimulation, comprising - a stimulation related basic data storage module (28) for storing the stimulation related basic data, - a stimulation rel ...

2019

A system for planning and/or providing neuromodulation

Vincent Delattre, Grégoire Courtine, Marco Capogrosso, Fabien Bertrand Paul Wagner, Karen Minassian

The present invention relates to a system for planning and/or providing neuromodulation (10), especially neurostimulation, comprising: - first data input module (26) for stimulation related basic data, - a stimulation related basic data storage module (28) ...

2019

System for planning and/or providing neuromodulation, especially neurostimulation

Vincent Delattre, Grégoire Courtine, Miroslav Caban, Marco Capogrosso, Fabien Bertrand Paul Wagner, Karen Minassian

The present invention relates system for planning and/or providing neuromodulation (10), especially neurostimulation, comprising - a neurostimulator (24) comprising a least one electrode (22), - functional mapping module (38) configured and arranged such t ...

2019

A system for planning and/or providing neurostimulation for a patient

Vincent Delattre, Tomislav Milekovic, Grégoire Courtine, Marco Capogrosso, Flavio Raschella, Fabien Bertrand Paul Wagner

The present invention relates to a system (10) for planning and/or providing neurostimulation for a patient, comprising: - a pathological spinal cord map storage module (48) for storing at least one pathological spinal cord map (49) describing the activati ...

2019

Cbp-dependent histone acetylation mediates axon regeneration induced by environmental enrichment in rodent spinal cord injury models

Grégoire Courtine, Quentin Barraud, Kay Alexander Bartholdi, Claudia Kathe, Thomas Haynes Hutson

After a spinal cord injury, axons fail to regenerate in the adult mammalian central nervous system, leading to permanent deficits in sensory and motor functions. Increasing neuronal activity after an injury using electrical stimulation or rehabilitation ca ...

AMER ASSOC ADVANCEMENT SCIENCE2019

System for selective spatiotemporal stimulation of the spinal cord

Silvestro Micera, Grégoire Courtine, Nikolaus Wenger, Marco Capogrosso, Jocelyne Bloch

The present disclosure refers to systems for electrical neurostimulation of a spinal cord of a subject in need of nervous system function support. In one example, a system comprises a signal processing device configured to receive signals from the subject ...

2019

Advantages of soft subdural implants for the delivery of electrochemical neuromodulation therapies to the spinal cord

Jérôme Gandar, Stéphanie Lacour, Grégoire Courtine, Nikolaus Wenger, Ivan Rusev Minev, Eduardo Martin Moraud, Pavel Musienko, Marco Capogrosso, Polina Shkorbatova, Nathan Antoine Greiner

Objective. We recently developed soft neural interfaces enabling the delivery of electrical and chemical stimulation to the spinal cord. These stimulations restored locomotion in animal models of paralysis. Soft interfaces can be placed either below or abo ...

2018

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