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Grégoire Courtine

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Publications associées (147)

Inhaling xenon ameliorates l -dopa-induced dyskinesia in experimental parkinsonism

Tomislav Milekovic, Grégoire Courtine, Eduardo Martin Moraud, Shiqi Sun

Parkinson's disease motor symptoms are treated with levodopa, but long‐term treatment leads to disabling dyskinesia. Altered synaptic transmission and maladaptive plasticity of corticostriatal glutamatergic projections play a critical role in the pathophys ...

2018

Required growth facilitators propel axon regeneration across complete spinal cord injury

Sabry Leonardo Barlatey, Grégoire Courtine, Cheng Wang, Mark Andrew Anderson, Michael V. Sofroniew, Zhigang He, Nicholas David James

Transected axons fail to regrow across anatomically complete spinal cord injuries (SCI) in adults. Diverse molecules can partially facilitate or attenuate axon growth during development or after injury1,2,3, but efficient reversal of this regrowth failure ...

2018

Configuration of electrical spinal cord stimulation through real-time processing of gait kinematics

Tomislav Milekovic, Jérôme Gandar, Grégoire Courtine, Nikolaus Wenger, Eduardo Martin Moraud, Pavel Musienko, Marco Capogrosso, Natalia Pavlova, Fabien Bertrand Paul Wagner, Polina Shkorbatova, Jocelyne Bloch

Epidural electrical stimulation (EES) of the spinal cord and real-time processing of gait kinematics are powerful methods for the study of locomotion and the improvement of motor control after injury or in neurological disorders. Here, we describe equipmen ...

2018

Brain-controlled modulation of spinal circuits improves recovery from spinal cord injury

Silvestro Micera, Grégoire Courtine, Marco Bonizzato, Natalia Pavlova, Galyna Pidpruzhnykova, Polina Shkorbatova

The delivery of brain-controlled neuromodulation therapies during motor rehabilitation may augment recovery from neurological disorders. To test this hypothesis, we conceived a brain-controlled neuromodulation therapy that combines the technical and practi ...

Nature Publishing Group2018

Cortico–reticulo–spinal circuit reorganization enables functional recovery after severe spinal cord contusion

Bernard Schneider, Léonie Asboth, Grégoire Courtine, Janine Beauparlant, Lucia Florinda Friedli Wittler, Selin Anil, Quentin Barraud, Cristina Martinez Gonzalez, Julie Kreider, Laetitia Danielle Philippine Baud, Mark Andrew Anderson, Galyna Pidpruzhnykova, Elodie Rey, Polina Shkorbatova

Severe spinal cord contusions interrupt nearly all brain projections to lumbar circuits producing leg movement. Failure of these projections to reorganize leads to permanent paralysis. Here we modeled these injuries in rodents. A severe contusion abolished ...

2018

Selective Recruitment of Arm Motoneurons in Nonhuman Primates Using Epidural Electrical Stimulation of the Cervical Spinal Cord

Giuseppe Schiavone, Camille Roux, Stéphanie Lacour, Grégoire Courtine, Marco Capogrosso, Beatrice Barra, Jocelyne Bloch

Recovery of reaching and grasping ability is the priority for people with cervical spinal cord injury (SCI). Epidural electrical stimulation (EES) has shown promising results in improving motor control after SCI in various animal models and in humans. Nota ...

2018

A neurostimulation system for central nervous stimulation (cns) and peripheral nervous stimulation (pns)

Sophie Marie Marthe Wurth, Silvestro Micera, Grégoire Courtine

The present disclosure relates to a neuromodulation and/or neurostimulation system comprising at least the following components: at least one sensing unit, at least control unit, at least one stimulation unit, at least one Central Nervous System (CNS) stim ...

2018

Optical cuff for optogenetic control of the peripheral nervous system

Léonie Asboth, Frédéric Pierre Gérald Michoud, Stéphanie Lacour, Loïc Sottas, Grégoire Courtine

Objective. Nerves in the peripheral nervous system (PNS) contain axons with specific motor, somatosensory and autonomic functions. Optogenetics offers an efficient approach to selectively activate axons within the nerve. However, the heterogeneous nature o ...

2018

Targeted neurotechnology restores walking in humans with spinal cord injury

Vincent Delattre, Camille Georgette Marie Le Goff-Mignardot, Salif Axel Komi, Elvira Pirondini, Roman Heimgartner, Grégoire Courtine, Miroslav Caban, Joachim von Zitzewitz, Marco Capogrosso, Jean-Baptiste Mignardot, Fabien Bertrand Paul Wagner, Robin Jonathan Demesmaeker, Andreas Rowald, Karen Minassian, Esra Neufeld, Jocelyne Bloch, Ismael Seanez Gonzalez, Hendrik Lambert, Anne Marie Lucienne Watrin, Perrine Seguin, Laura Ann McCracken, Molywan Vat, Edoardo Paoles

2018

Closed-loop control of trunk posture improves locomotion through the regulation of leg proprioceptive feedback after spinal cord injury

Jenifer Cléa Miehlbradt, Sophie Marie Marthe Wurth, Silvestro Micera, Grégoire Courtine, Joachim von Zitzewitz, Eduardo Martin Moraud, Emanuele Formento, Marco Capogrosso

Nature Research2018

Long-term functionality of a soft electrode array for epidural spinal cord stimulation in a minipig model

Giuseppe Schiavone, Nicolas Vachicouras, Florian Dylan Fallegger, Stéphanie Lacour, Grégoire Courtine, Marco Capogrosso, Fabien Bertrand Paul Wagner, Beatrice Barra, Jocelyne Bloch, Xiaoyang Kang

IEEE2018

Two-phase calibration of a neuroprosthetic system

Tomislav Milekovic, Jérôme Gandar, Grégoire Courtine, Eduardo Martin Moraud, Marco Capogrosso, Fabien Bertrand Paul Wagner

Methods and systems are provided for triggering electrical stimulation of a spinal cord during execution of a motor event. In one example, a method comprises monitoring motor cortex activity while execution of a desired motor movement is attempted during a ...

2018

Reducing neuronal inhibition restores locomotion in paralysed mice

Grégoire Courtine

2018

A sensory information compliant spinal cord stimulation system for the rehabilitation of motor functions

Silvestro Micera, Grégoire Courtine, Emanuele Formento, Marco Capogrosso, Karen Minassian

The present invention refers to a system for stimulation of the spinal cord for the rehabilitation of motor function in subjects with spinal cord injury or other motor disorders. Said system comprises a programmable implantable pulse generator (IPG), opera ...

2018

Targeted neurotechnologies enabling walking after paralysis

Grégoire Courtine

MARY ANN LIEBERT, INC2018

Apparatus comprising a support system for a user and its operation in a gravity-assist mode

Camille Georgette Marie Le Goff-Mignardot, Grégoire Courtine, Joachim von Zitzewitz, Jean-Baptiste Mignardot

The present application relates to devices and systems for rehabilitation of the locomotor system, for example limbs. In particular, the present application discloses an apparatus, more in particular a robotic platform capable of optimizing gravity-depende ...

2018

Long-term functionality of a soft electrode array for epidural spinal cord stimulation in a minipig model

Giuseppe Schiavone, Nicolas Vachicouras, Florian Dylan Fallegger, Stéphanie Lacour, Grégoire Courtine, Marco Capogrosso, Fabien Bertrand Paul Wagner, Beatrice Barra, Jocelyne Bloch, Xiaoyang Kang

Long-term biointegration of man-made neural interfaces is influenced by the mechanical properties of the implant materials. Substantial experimental work currently aims at replacing conventional hard implant materials with soft alternatives that can favour ...

IEEE2018

System to deliver adaptive epidural and/or subdural electrical spinal cord stimulation to facilitate and restore locomotion after a neuromotor impairment

Silvestro Micera, Grégoire Courtine, Nikolaus Wenger, Marco Bonizzato, Eduardo Martin Moraud

The present disclosure provides a closed-loop system for real-time control of epidural and/or subdural electrical stimulation comprising means for applying to a subject neuromodulation with adjustable stimulation parameters, said means being operatively co ...

2018

Electrical spinal cord stimulation must preserve proprioception to enable locomotion in humans with spinal cord injury

Camille Georgette Marie Le Goff-Mignardot, Silvestro Micera, Grégoire Courtine, Emanuele Formento, Marco Capogrosso, Jean-Baptiste Mignardot, Fabien Bertrand Paul Wagner, Andreas Rowald, Karen Minassian, Jocelyne Bloch

Epidural electrical stimulation (EES) of the spinal cord restores locomotion in animal models of spinal cord injury but is less effective in humans. Here we hypothesized that this interspecies discrepancy is due to interference between EES and propriocepti ...

2018

Applying Whole Organ Clearing Techniques To Spinal Cord Injury: A Survey Of Techniques

Olivier Burri, Thierry Laroche, Laura Battista, Grégoire Courtine, Romain Guiet, Quentin Barraud, Newton Cho

MARY ANN LIEBERT2018

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