Recherche

Afficher tous les résultats pour

Accueil

Personne

Grégoire Courtine

À propos
Confidentialité
Mentions légales

Graph Chatbot

Publications associées (147)

Decoding bipedal locomotion from the rat sensorimotor cortex

Silvestro Micera, Grégoire Courtine, Lucia Florinda Friedli Wittler, Rubia van den Brand, Jacopo Rigosa

Objective. Decoding forelimb movements from the firing activity of cortical neurons has been interfaced with robotic and prosthetic systems to replace lost upper limb functions in humans. Despite the potential of this approach to improve locomotion and fac ...

Institute of Physics2015

Defining Ecological Strategies in Neuroprosthetics

Grégoire Courtine, Jocelyne Bloch

Neurological disorders disrupt the equilibrium within the brain and spinal cord ecosystems. Ecology reuses, recycles, and reduces to help maintain the balance across ecosystems. Likewise, neuroprosthetics can help the brain help itself with ecoprosthetic d ...

Elsevier2015

Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by alpha-synuclein overexpression

Grégoire Courtine, Isabel Laura Vollenweider, Laetitia Danielle Philippine Baud

Introduction: Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons as well as the presence of proteinaceous inclusions named Lewy bodies. alpha synuclein (alpha-syn) is a major constituent o ...

2015

Biomaterials. Electronic dura mater for long-term multimodal neural interfaces

Tomislav Milekovic, Léonie Asboth, Jérôme Gandar, Nicolas Vachicouras, Stéphanie Lacour, Arthur Edouard Hirsch, Silvestro Micera, Grégoire Courtine, Nikolaus Wenger, Ivan Rusev Minev, Quentin Barraud, Simone Ellen Joze Duis, Eduardo Martin Moraud, Pavel Musienko, Marco Capogrosso, Natalia Pavlova

The mechanical mismatch between soft neural tissues and stiff neural implants hinders the long-term performance of implantable neuroprostheses. Here, we designed and fabricated soft neural implants with the shape and elasticity of dura mater, the protectiv ...

American Association for the Advancement of Science2015

Leveraging biomedical informatics for assessing plasticity and repair in primate spinal cord injury

Grégoire Courtine

Recent preclinical advances highlight the therapeutic potential of treatments aimed at boosting regeneration and plasticity of spinal circuitry damaged by spinal cord injury (SCI). With several promising candidates being considered for translation into cli ...

Elsevier Science Bv2015

Muscle Spindle Feedback Directs Locomotor Recovery And Circuit Reorganization After Spinal Cord Injury

Grégoire Courtine, Isabel Laura Vollenweider

Mary Ann Liebert, Inc2015

Closed-loop neuromodulation of spinal sensorimotor circuits controls refined locomotion after complete spinal cord injury

Silvestro Micera, Grégoire Courtine, Nikolaus Wenger, Stanisa Raspopovic, Marco Bonizzato, Eduardo Martin Moraud, Pavel Musienko

Neuromodulation of spinal sensorimotor circuits improves motor control in animal models and humans with spinal cord injury. With common neuromodulation devices, electrical stimulation parameters are tuned manually and remain constant during movement. We de ...

American Association for the Advancement of Science2014

Modeling Spinal Cord Injury In The Primate

Grégoire Courtine

Mary Ann Liebert, Inc2014

Corticospinal neuroprostheses to restore locomotion after spinal cord injury

José del Rocio Millán Ruiz, Stéphanie Lacour, Silvestro Micera, Grégoire Courtine, Nikolaus Wenger, Ivan Rusev Minev, Marco Bonizzato, Janine Beauparlant, Eduardo Martin Moraud, Pavel Musienko, David Allenson Borton

In this conceptual review, we highlight our strategy for, and progress in the development of corticospinal neuroprostheses for restoring locomotor functions and promoting neural repair after thoracic spinal cord injury in experimental animal models. We spe ...

Elsevier2014

Domains Of Neural Control Of Walking In Human Spinal Cord Injury

Grégoire Courtine

Mary Ann Liebert, Inc2014

Wireless Neurosensor for Full-Spectrum Electrophysiology Recordings during Free Behavior

Yao Lu, Grégoire Courtine, David Allenson Borton, Jean François Pierre Laurens, Hao Li

Brain recordings in large animal models and humans typically rely on a tethered connection, which has restricted the spectrum of accessible experimental and clinical applications. To overcome this limitation, we have engineered a compact, lightweight, high ...

Cell Press2014

Development of a Database for Translational Spinal Cord Injury Research

Grégoire Courtine

Efforts to understand spinal cord injury (SCI) and other complex neurotrauma disorders at the pre-clinical level have shown progress in recent years. However, successful translation of basic research into clinical practice has been slow, partly because of ...

Mary Ann Liebert2014

Muscle Spindle Feedback Directs Locomotor Recovery and Circuit Reorganization after Spinal Cord Injury

Grégoire Courtine, Isabel Laura Vollenweider

Spinal cord injuries alter motor function by disconnecting neural circuits above and below the lesion, rendering sensory inputs a primary source of direct external drive to neuronal networks caudal to the injury. Here, we studied mice lacking functional mu ...

Elsevier2014

Undirected compensatory plasticity contributes to neuronal dysfunction after severe spinal cord injury

Grégoire Courtine, Janine Beauparlant, Lucia Florinda Friedli Wittler, Rubia van den Brand, Quentin Barraud, Pavel Musienko

Severe spinal cord injury in humans leads to a progressive neuronal dysfunction in the chronic stage of the injury. This dysfunction is characterized by premature exhaustion of muscle activity during assisted locomotion, which is associated with the emerge ...

Oxford University Press2013

Soft Robot for Gait Rehabilitation of Spinalized Rodents

Silvestro Micera, Jamie Paik, Grégoire Courtine, Yi Sun, Joachim von Zitzewitz, Rubia van den Brand, Yun Seong Song

Soft actuators made of highly elastic polymers allow novel robotic system designs, yet application-specific soft robotic systems are rarely reported. Taking notice of the characteristics of soft pneumatic actuators (SPAs) such as high customizability and l ...

Ieee2013

Personalized neuroprosthetics

José del Rocio Millán Ruiz, Silvestro Micera, Grégoire Courtine, David Allenson Borton

Decades of technological developments have populated the field of neuroprosthetics with myriad replacement strategies, neuromodulation therapies, and rehabilitation procedures to improve the quality of life for individuals with neuromotor disorders. Despit ...

American Association for the Advancement of Science2013

A real-time platform for studying the modulatory capacity of epidural stimulation after spinal cord injury

Jérôme Gandar, Silvestro Micera, Grégoire Courtine, Nikolaus Wenger, Eduardo Martin Moraud, Pavel Musienko

Epidural electrical stimulation (EES) showed promises to improve standing and walking after neurological disorders. To date, EES has been delivered continuously, although time-dependent stimulations would likely be more efficient to activate specific subse ...

Ieee2013

Brain–machine interface: closer to therapeutic reality?

José del Rocio Millán Ruiz, Silvestro Micera, Grégoire Courtine

Elsevier Science Inc2013

A Computational Model for Epidural Electrical Stimulation of Spinal Sensorimotor Circuits

Silvestro Micera, Grégoire Courtine, Nikolaus Wenger, Stanisa Raspopovic, Janine Beauparlant, Pavel Musienko, Marco Capogrosso

Epidural electrical stimulation (EES) of lumbosacral segments can restore a range of movements after spinal cord injury. However, the mechanisms and neural structures through which EES facilitates movement execution remain unclear. Here, we designed a comp ...

Society for Neuroscience2013

Multisystem Neuroprosthetic Training Improves Bladder Function After Severe Spinal Cord Injury

Daniel Eberli, Grégoire Courtine, Janine Beauparlant, Rubia van den Brand

Severe spinal cord injury leads to neurogenic bladder dysfunction. We recently developed a multisystem neuroprosthetic training program that promotes plastic changes capable of restoring refined locomotion in rats with severe spinal cord injury. We investi ...

Elsevier Science Inc2013

Page 7 sur 8