Grégoire Courtine

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Publications associées (147)

Methods for Functional Assessment After C7 Spinal Cord Hemisection in the Rhesus Monkey

Grégoire Courtine

Background. Reliable outcome measures are essential for preclinical modeling of spinal cord injury (SCI) in primates. Measures need to be sensitive to both increases and decreases in function in order to demonstrate potential positive or negative effects o ...

2012

Animal Models of Neurologic Disorders: A Nonhuman Primate Model of Spinal Cord Injury

Grégoire Courtine

Primates are an important and unique animal resource. We have developed a nonhuman primate model of spinal cord injury (SCI) to expand our knowledge of normal primate motor function, to assess the impact of disease and injury on sensory and motor function, ...

2012

Versatile robotic interface to evaluate, enable and train locomotion and balance after neuromotor disorders

Grégoire Courtine, Lucia Florinda Friedli Wittler, Rubia van den Brand, Pavel Musienko

Central nervous system (CNS) disorders distinctly impair locomotor pattern generation and balance, but technical limitations prevent independent assessment and rehabilitation of these subfunctions. Here we introduce a versatile robotic interface to evaluat ...

Nature Publishing Group2012

Restoring Voluntary Control of Locomotion after Paralyzing Spinal Cord Injury

Silvestro Micera, Grégoire Courtine, Lucia Florinda Friedli Wittler, Rubia van den Brand, Quentin Barraud, Kay Alexander Bartholdi, Simone Ellen Joze Duis, Eduardo Martin Moraud, Isabel Laura Vollenweider, Pavel Musienko

Half of human spinal cord injuries lead to chronic paralysis. Here, we introduce an electrochemical neuroprosthesis and a robotic postural interface designed to encourage supraspinally-mediated movements in rats with paralyzing lesions. Despite the interru ...

American Association for the Advancement of Science2012

Response to Comment on "Restoring Voluntary Control of Locomotion After Paralyzing Spinal Cord Injury"

Grégoire Courtine, Janine Beauparlant, Rubia van den Brand

Slawinska et al. questioned the involvement of supraspinal centers in restoring locomotion after multisystem neuroprosthetic training in rats with paralyzing spinal cord injury. Here, we clarify misconceptions and present additional results illustrating th ...

American Association for the Advancement of Science2012

Plasticity of functional connectivity in the adult spinal cord

Grégoire Courtine

This paper emphasizes several characteristics of the neural control of locomotion that provide opportunities for developing strategies to maximize the recovery of postural and locomotor functions after a spinal cord injury (SCI). The major points of this p ...

2006

Kinematic and EMG Determinants in Quadrupedal Locomotion of a Non-Human Primate (Rhesus)

Grégoire Courtine

We hypothesized that the activation patterns of flexor and extensor muscles and the resulting kinematics of the forelimbs and hindlimbs during locomotion in the Rhesus would have unique characteristics relative to other quadrupedal mammals. Adaptations of ...

2005

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