Publications de Frédéric Bruno Martin Gachon

Mice with humanized livers reveal the role of hepatocyte clocks in rhythmic behavior

Cédric Gobet, Sylviane Métairon, Frédéric Bruno Martin Gachon, Benjamin Dieter Weger

The synchronization of circadian clock depends on a central pacemaker located in the suprachiasmatic nuclei. However, the potential feedback of peripheral signals on the central clock remains poorly characterized. To explore whether peripheral organ circad ...

AMER ASSOC ADVANCEMENT SCIENCE2023

Systematic analysis of differential rhythmic liver gene expression mediated by the circadian clock and feeding rhythms

Felix Naef, Cédric Gobet, Fabrice David, Frédéric Bruno Martin Gachon, Benjamin Dieter Weger, Nicholas Edward Phillips

The circadian clock and feeding rhythms are both important regulators of rhythmic gene expression in the liver. To further dissect the respective contributions of feeding and the clock, we analyzed differential rhythmicity of liver tissue samples across se ...

National Academy of Sciences2021

Robust landscapes of ribosome dwell times and aminoacyl-tRNAs in response to nutrient stress in liver

Felix Naef, Cédric Gobet, Frédéric Bruno Martin Gachon, Benjamin Dieter Weger, Nagammal Neelagandan

Translation depends on messenger RNA (mRNA)-specific initiation, elongation, and termination rates. While translation elongation is well studied in bacteria and yeast, less is known in higher eukaryotes. Here we combined ribosome and transfer RNA (tRNA) pr ...

National Academy of Sciences2020

Chronotype: Implications for Epidemiologic Studies on Chrono-Nutrition and Cardiometabolic Health

Frédéric Bruno Martin Gachon

Chrono-nutrition is an emerging research field in nutritional epidemiology that encompasses 3 dimensions of eating behavior: timing, frequency, and regularity. To date, few studies have investigated how an individual's circadian typology, i.e., one's chron ...

OXFORD UNIV PRESS2019

At the Intersection of Microbiota and Circadian Clock: Are Sexual Dimorphism and Growth Hormones the Missing Link to Pathology? Circadian Clock and Microbiota: Potential Egffect on Growth Hormone and Sexual Development

Frédéric Bruno Martin Gachon, Benjamin Dieter Weger

Reciprocal interactions between the host circadian clock and the microbiota are evidenced by recent literature. Interestingly, dysregulation of either the circadian clock or microbiota is associated with common human pathologies such as obesity, type 2 dia ...

WILEY2019

The Mouse Microbiome Is Required for Sex-Specific Diurnal Rhythms of Gene Expression and Metabolism

Felix Naef, Cédric Gobet, Jake Yeung, Frédéric Bruno Martin Gachon, Benjamin Dieter Weger

The circadian clock and associated feeding rhythms have a profound impact on metabolism and the gut microbiome. To what extent microbiota reciprocally affect daily rhythms of physiology in the host remains elusive. Here, we analyzed transcriptome and metab ...

Cell Press2019

Microbiota and the clock: sexual dimorphism matters!

Frédéric Bruno Martin Gachon, Benjamin Dieter Weger

IMPACT JOURNALS LLC2019

Circadian Regulation of Cochlear Sensitivity to Noise by Circulating Glucocorticoids

Frédéric Bruno Martin Gachon, Benjamin Dieter Weger

The cochlea possesses a robust circadian clock machinery that regulates auditory function. How the cochlear clock is influenced by the circadian system remains unknown. Here, we show that cochlear rhythms are system driven and require local Bmal1 as well a ...

2019

Clock-dependent chromatin topology modulates circadian transcription and behavior

Felix Naef, Cédric Gobet, Damien Lionel Nicolas, Kyle Gustafson, Jake Yeung, Clémence Yumie Syloun Hurni, Jérôme Mermet, Celine Jouffe, Daniel Alain Dominique Marie Mauvoisin, Frédéric Bruno Martin Gachon

Cold Spring Harbor Laboratory Press2018

Transcription factor activity rhythms and tissue-specific chromatin interactions explain circadian gene expression across organs

Felix Naef, Jake Yeung, Jérôme Mermet, Celine Jouffe, Frédéric Bruno Martin Gachon

Cold Spring Harbor Laboratory Press2018

Transcriptomic analyses reveal rhythmic and CLOCK-driven pathways in human skeletal muscle

Cédric Gobet, Frédéric Bruno Martin Gachon, Benjamin Dieter Weger

2018

Cross-regulatory circuits linking inflammation, high-fat diet, and the circadian clock

Felix Naef, Jake Yeung, Frédéric Bruno Martin Gachon

Mammalian physiology resonates with the daily changes in the external environment, allowing processes such as rest-activity cycles, metabolism, and body temperature to synchronize with daily changes in the surroundings. Studies have identified the molecula ...

COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT2018

Pancreatic α- and β-Cellular Clocks Have Distinct Molecular Properties and Impact on Islet Hormone Secretion and Gene Expression

Michaël Unser, Daniel Sage, Cédric Gobet, Frédéric Bruno Martin Gachon

A critical role of circadian oscillators in orchestrating insulin secretion and islet gene transcription has been demonstrated recently. However, these studies focused on whole islets and did not explore the interplay between α-cell and β-cell clocks. We p ...

2017

Transcriptional regulatory logic of the diurnal cycle in the mouse liver

Felix Naef, Jonathan Aryeh Sobel, Guillaume Rey, Irina Krier, Nouria Hernandez, Bart Deplancke, Matteo Dal Peraro, Sunil Kumar Raghav, Frédéric Bruno Martin Gachon, Alexandra Styliani Kalantzi, Benjamin Dieter Weger

Many organisms exhibit temporal rhythms in gene expression that propel diurnal cycles in physiology. In the liver of mammals, these rhythms are controlled by transcription-translation feedback loops of the core circadian clock and by feeding-fasting cycles ...

Public Library of Science2017

Regulation of Mammalian Physiology by interconnected Circadian and Feeding Rhythms

Cédric Gobet, Florian Atger, Daniel Alain Dominique Marie Mauvoisin, Frédéric Bruno Martin Gachon, Benjamin Dieter Weger

Circadian clocks are endogenous timekeeping systems that adapt in an anticipatory fashion the physiology and behavior of most living organisms. In mammals, the master pacemaker resides in the suprachiasmatic nucleus and entrains peripheral clocks using a w ...

Frontiers Media Sa2017

Lipidomics reveals diurnal lipid oscillations in human skeletal muscle persisting in cellular myotubes cultured in vitro

Marc Moniatte, Howard Riezman, Jonathan Paz Montoya, Frédéric Bruno Martin Gachon, Benjamin Dieter Weger

Circadian clocks play an important role in lipid homeostasis, with impact on various metabolic diseases. Due to the central role of skeletal muscle in whole-body metabolism, we aimed at studying muscle lipid profiles in a temporal manner. Moreover, it has ...

National Academy of Sciences2017

Nuclear Proteomics Uncovers Diurnal Regulatory Landscapes in Mouse Liver

Felix Naef, Loïc Dayon, Martin Kussmann, Jingkui Wang, Florian Atger, Daniel Alain Dominique Marie Mauvoisin, Frédéric Bruno Martin Gachon, Federico Sizzano

Diurnal oscillations of gene expression controlled by the circadian clock and its connected feeding rhythm enable organisms to coordinate their physiologies with daily environmental cycles. While available techniques yielded crucial insights into regulatio ...

Cell Press2017

The genomic landscape of human cellular circadian variation points to a novel role for the signalosome

Daniel Alain Dominique Marie Mauvoisin, Frédéric Bruno Martin Gachon, Konstantin Popadin

The importance of natural gene expression variation for human behavior is undisputed, but its impact on circadian physiology remains mostly unexplored. Using umbilical cord fibroblasts, we have determined by genome-wide association how common genetic varia ...

Elife Sciences Publications Ltd2017

Circadian and Feeding Rhythms Orchestrate the Diurnal Liver Acetylome

Felix Naef, Loïc Dayon, Carlos Canto Alvarez, Martin Kussmann, Jingkui Wang, Sebastiano Collino, Florian Atger, Daniel Alain Dominique Marie Mauvoisin, Frédéric Bruno Martin Gachon, Joanna Ratajczak

Lysine acetylation is involved in various biological processes and is considered a key reversible post-translational modification in the regulation of gene expression, enzyme activity, and subcellular localization. This post-translational modification is t ...

Elsevier2017

Diurnal Oscillations in Liver Mass and Cell Size Accompany Ribosome Assembly Cycles

Jingkui Wang, Daniel Alain Dominique Marie Mauvoisin, Frédéric Bruno Martin Gachon

The liver plays a pivotal role in metabolism and xenobiotic detoxification, processes that must be particularly efficient when animals are active and feed. A major question is how the liver adapts to these diurnal changes in physiology. Here, we show that, ...

Cell Press2017