Mitotic bookmarking transcription factors remain bound to chromosomes during mitosis and were proposed to regulate phenotypic maintenance of stem and progenitor cells at the mitosis-to-G1 (M-G1) transition. However, mitotic bookmarking remains largely unex ...

Cold Spring Harbor Laboratory2016

Room temperature strong coupling between a microwave oscillator and an ensemble of electron spins

Giovanni Boero, Jürgen Brugger, Jens Anders, Radoslaw Lisowski, Gabriele Gualco, David Michael Suter

We demonstrate theoretically and experimentally the possibility to achieve the strong coupling regime at room temperature with a microwave electronic oscillator coupled with an ensemble of electron spins. The coupled system shows bistable behaviour, with a ...

Academic Press Inc - Elsevier Science2013

Stimulus-induced modulation of transcriptional bursting in a single mammalian gene

Felix Naef, Benjamin Zoller, Rosamaria Cannavo, David Michael Suter

Mammalian genes are often transcribed discontinuously as short bursts of RNA synthesis followed by longer silent periods. However, how these "on" and "off" transitions, together with the burst sizes, are modulated in single cells to increase gene expressio ...

National Academy of Sciences2013

Circadian Dbp Transcription Relies on Highly Dynamic BMAL1-CLOCK Interaction with E Boxes and Requires the Proteasome

Felix Naef, David Michael Suter

The transcription factors BMAL1 and CLOCK drive the circadian transcription of clock and clock-controlled genes, such as Dbp. To investigate the kinetics of BMAL1 binding to target genes in real time, we generated a cell line harboring tandem arrays of Dbp ...

Elsevier2012

The mammalian circadian timing system: synchronization of peripheral clocks

David Michael Suter

Mammalian physiology has to adapt to daily alternating periods during which animals either forage and feed or sleep and fast. The adaptation of physiology to these oscillations is controlled by a circadian timekeeping system, in which a master pacemaker in ...

2011

Mammalian genes are transcribed with widely different bursting kinetics

Felix Naef, David Michael Suter

In prokaryotes and eukaryotes, most genes appear to be transcribed during short periods called transcriptional bursts, interspersed by silent intervals. We describe how such bursts generate gene-specific temporal patterns of messenger RNA (mRNA) synthesis ...

American Association for the Advancement of Science2011

Origins and consequences of transcriptional discontinuity

Felix Naef, David Michael Suter

In both prokaryotes and eukaryotes, transcription has been described as being temporally discontinuous, most genes being active mainly during short activity windows interspersed by silent periods. In mammalian cells, recent studies performed at the single ...

2011

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