Publications de Julie Marie Russeil

Transcriptomic profiling of murine GnRH neurons reveals developmental trajectories linked to human reproduction and infertility

Bart Deplancke, Julie Marie Russeil, Daniel Alpern, Vincent Roland Julien Gardeux

Rationale: Neurons producing Gonadotropin-Releasing Hormone (GnRH) are essential for human reproduction and have to migrate from nose to brain during prenatal life. Impaired GnRH neuron biology results in alterations of the reproductive axis, including del ...

2025

Context transcription factors establish cooperative environments and mediate enhancer communication

Bart Deplancke, Julie Marie Russeil, Vincent Roland Julien Gardeux, Judith Franziska Kribelbauer, Guido Van Mierlo

Many enhancers control gene expression by assembling regulatory factor clusters, also referred to as condensates. This process is vital for facilitating enhancer communication and establishing cellular identity. However, how DNA sequence and transcription ...

2024

A human omentum-specific mesothelial-like stromal population inhibits adipogenesis through IGFBP2 secretion

Bart Deplancke, Pernille Yde Rainer, Radiana Ferrero, Julie Marie Russeil, Magda Zachara, Daniel Alpern, Vincent Roland Julien Gardeux, Jörn Pezoldt, Guido Van Mierlo

Although several mouse and human adipose SVF cellular subpopulations have by now been identified, we still lack an understanding of the cellular and functional variability of adipose stem and progenitor cell (ASPC) populations across human fat depots. To a ...

Cell Press2024

Mammalian adipogenesis regulator (Areg) cells use retinoic acid signalling to be non- and anti-adipogenic in age-dependent manner

Bart Deplancke, Pernille Yde Rainer, Radiana Ferrero, Julie Marie Russeil, Horia Hashimi, Magda Zachara, Daniel Alpern, Maria Litovchenko

Adipose stem and precursor cells (ASPCs) give rise to adipocytes and determine the composition and plasticity of adipose tissue. Recently, several studies have demonstrated that ASPCs partition into at least three distinct cell subpopulations, including th ...

WILEY2022

Deterministic scRNA-seq captures variation in intestinal crypt and organoid composition

Matthias Lütolf, Bart Deplancke, Saba Rezakhani, Esther Amstad, Riccardo Dainese, Julie Marie Russeil, Antonius Chrisnandy, Vincent Roland Julien Gardeux, Johannes Julius Bues, Marjan Biocanin, Rita Sarkis, Jörn Pezoldt

DisCo is a deterministic droplet microfluidics tool for single-cell analysis on low cell input samples, which is demonstrated to profile individual intestinal organoids and in vivo-derived small tissues. ...

NATURE PORTFOLIO2022

A Tead1-Apelin axis directs paracrine communication from myogenic to endothelial cells in skeletal muscle

Bart Deplancke, Maria Deak, Sonia Karaz, Umji Lee, Julie Marie Russeil, Benjamin D. Cosgrove

Apelin (Apln) is a myokine that regulates skeletal muscle plasticity and meta-bolism and declines during aging. Through a yeast one-hybrid transcription factor binding screen, we identified the TEA domain transcription factor 1 (Tead1) as a novel regulator ...

CELL PRESS2022

Postnatal expansion of mesenteric lymph node stromal cells towards reticular and CD34(+) stromal cell subsets

Bart Deplancke, Julie Marie Russeil, Wanze Chen, Vincent Roland Julien Gardeux, Maria Litovchenko, Marjan Biocanin, Jörn Pezoldt, Guido Van Mierlo

Gut-draining mesenteric lymph nodes (LN) provide the framework to shape intestinal adaptive immune responses. Based on the transcriptional signatures established by our previous work, the composition and immunomodulatory function of LN stromal cells (SC) v ...

Nature Portfolio2022

A leukemia-protective germline variant mediates chromatin module formation via transcription factor nucleation

Freddy Radtke, Ute Koch, Bart Deplancke, Riccardo Dainese, Julie Marie Russeil, Daniel Alpern, Vincent Roland Julien Gardeux, Maria Litovchenko, Gerard Llimos Aubach, Jörn Pezoldt, Judith Franziska Kribelbauer

Non-coding variants coordinate transcription factor (TF) binding and chromatin mark enrichment changes over regions spanning >100 kb. These molecularly coordinated regions are named "variable chromatin modules" (VCMs), providing a conceptual framework of h ...

Nature Portfolio2022

Disparate temperature-dependent virus-host dynamics for SARS-CoV-2 and SARS-CoV in the human respiratory epithelium

Bastien Mangeat, Bart Deplancke, Julie Marie Russeil, Daniel Alpern, Vincent Roland Julien Gardeux, Elisa Cora, Jörn Pezoldt

Since its emergence in December 2019, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has spread globally and become a major public health burden. Despite its close phylogenetic relationship to SARS-CoV, SARS-CoV-2 exhibits increased human-to- ...

2021

Extensive tissue-specific expression variation and novel regulators underlying circadian behavior

Michael Vincent Frochaux, Bart Deplancke, Matteo Dal Peraro, Antonio Carlos Alves Meireles Filho, Roel Paulus Josephus Bevers, Alessio Prunotto, Julie Marie Russeil, Virginie Sandra Braman, Vincent Roland Julien Gardeux, Maria Litovchenko, Brian Dennis Hollis

Natural genetic variation affects circadian rhythms across the evolutionary tree, but the underlying molecular mechanisms are poorly understood. We investigated population-level, molecular circadian clock variation by generating >700 tissue-specific transc ...

2021

The Hippo pathway controls myofibril assembly and muscle fiber growth by regulating sarcomeric gene expression

Bart Deplancke, Julie Marie Russeil, Daniel Alpern

Skeletal muscles are composed of gigantic cells called muscle fibers, packed with force-producing myofibrils. During development, the size of individual muscle fibers must dramatically enlarge to match with skeletal growth. How muscle growth is coordinated ...

2021

Mitochondrial gene signature in the prefrontal cortex for differential susceptibility to chronic stress

Maria del Carmen Sandi Perez, Rolf Gruetter, Bart Deplancke, Antoine Timothée Cherix, Jocelin Grosse, Julie Marie Russeil, Daniel Alpern, Meltem Weger, Sriparna Ghosal

Mitochondrial dysfunction was highlighted as a crucial vulnerability factor for the development of depression. However, systemic studies assessing stress-induced changes in mitochondria-associated genes in brain regions relevant to depression symptomatolog ...

2020

BRB-seq: ultra-affordable high-throughput transcriptomics enabled by bulk RNA barcoding and sequencing

David Hacker, Bastien Mangeat, Bart Deplancke, Antonio Carlos Alves Meireles Filho, Julie Marie Russeil, Daniel Alpern, Vincent Roland Julien Gardeux

Despite its widespread use, RNA-seq is still too laborious and expensive to replace RT-qPCR as the default gene expression analysis method. We present a novel approach, BRB-seq, which uses early multiplexing to produce 3 cDNA libraries for dozens of sample ...

2019

Systems-Genetics-Based Inference of a Core Regulatory Network Underlying White Fat Browning

Bart Deplancke, Petra Catalina Schwalie, Julie Marie Russeil

Recruitment of brite/beige cells, known as browning of white adipose tissue (WAT), is an efficient way to turn an energy-storing organ into an energy-dissipating one and may therefore be of therapeutic value in combating obesity. However, a comprehensive u ...

2019

ZFP30 promotes adipogenesis through the KAP1-mediated activation of a retrotransposon-derived Pparg2 enhancer

Carine Delattre-Gubelmann, Didier Trono, Julien Léonard Duc, Bart Deplancke, Sunil Kumar Raghav, Marco Cassano, Michaël Imbeault, Petra Catalina Schwalie, Suk Min Jang, Riccardo Dainese, Julie Marie Russeil, Wanze Chen, Evgeniia Pankevich

Krüppel-associated box zinc finger proteins (KZFPs) constitute the largest family of mammalian transcription factors, but most remain completely uncharacterized. While initially proposed to primarily repress transposable elements, recent reports have revea ...

Nature Research2019

A stromal cell population that inhibits adipogenesis in mammalian fat depots

Bart Deplancke, Petra Catalina Schwalie, Julie Marie Russeil, Magda Zachara, Daniel Alpern

2018

Dissecting the brown adipogenic regulatory network using integrative genomics

Bart Deplancke, Sunil Kumar Raghav, Rachana Narendra Pradhan, Petra Catalina Schwalie, Julie Marie Russeil, Wanze Chen, Daniel Alpern, Vincent Roland Julien Gardeux, Johannes Julius Bues

Brown adipocytes regulate energy expenditure via mitochondrial uncoupling, which makes them attractive therapeutic targets to tackle obesity. However, the regulatory mechanisms underlying brown adipogenesis are still poorly understood. To address this, we ...

Springer Nature2017