Publications de Torgil Elias Friman

Endogenous fluctuations of OCT 4 and SOX 2 bias pluripotent cell fate decisions

Cédric Deluz, David Michael Suter, Daniel Strebinger, Andrea Brigitta Alber, Torgil Elias Friman, Subashika Govindan

SOX2 and OCT4 are pioneer transcription factors playing a key role in embryonic stem (ES) cell self‐renewal and differentiation. How temporal fluctuations in their expression levels bias lineage commitment is unknown. Here, we generated knock‐in reporter f ...

2019

Mitotic chromosome binding predicts transcription factor properties in interphase

Cédric Deluz, Mahé Cécile Raccaud, David Michael Suter, Andrea Brigitta Alber, Torgil Elias Friman

Mammalian transcription factors (TFs) differ broadly in their nuclear mobility and sequence-specific/non-specific DNA binding. How these properties affect their ability to occupy specific genomic sites and modify the epigenetic landscape is unclear. The as ...

Nature Research2019

Dynamic regulation of chromatin accessibility by pluripotency transcription factors across the cell cycle

Cédric Deluz, Bart Deplancke, David Michael Suter, Antonio Carlos Alves Meireles Filho, Torgil Elias Friman, Vincent Roland Julien Gardeux, Subashika Govindan

The pioneer activity of transcription factors allows for opening of inaccessible regulatory elements and has been extensively studied in the context of cellular differentiation and reprogramming. In contrast, the function of pioneer activity in self-renewi ...

2019

The role of OCT4 and SOX2 in regulating chromatin accessibility and cell fate across the cell cycle in embryonic stem cells

Torgil Elias Friman

Precise spatiotemporal regulation of gene expression is essential for development and homeostasis of complex organisms. This is achieved in large part by sequence-specific transcription factors (TF) that bind to genomic regulatory elements to activate or r ...

EPFL2019

Quantitative relationships between SMAD dynamics and target gene activation kinetics in single live cells

Felix Naef, Onur Tidin, David Michael Suter, Torgil Elias Friman

The transduction of extracellular signals through signaling pathways that culminate in a transcriptional response is central to many biological processes. However, quantitative relationships between activities of signaling pathway components and transcript ...

Nature Research2019

OCT4 and SOX2 are required at the M-G1 transition to re-establish chromatin accessibility at enhancers in pluripotent stem cells

Cédric Deluz, David Michael Suter, Antonio Carlos Alves Meireles Filho, Torgil Elias Friman, Vincent Roland Julien Gardeux

MARY ANN LIEBERT, INC2018

Endogenous fluctuations of OCT4 and SOX2 bias pluripotent cell fate decisions

Cédric Deluz, David Michael Suter, Daniel Strebinger, Andrea Brigitta Alber, Torgil Elias Friman, Subashika Govindan

MARY ANN LIEBERT, INC2018

Mitotic chromosome association predicts genome-wide transcription factor occupancy and impact on local chromatin accessibility

Cédric Deluz, Mahé Cécile Raccaud, David Michael Suter, Andrea Brigitta Alber, Torgil Elias Friman

MARY ANN LIEBERT, INC2018

A role for mitotic bookmarking of SOX2 in pluripotency and differentiation

Cédric Deluz, Mahé Cécile Raccaud, Suliana Manley, Marion Leleu, Aleksandr Benke, Andrea Callegari, David Michael Suter, Daniel Strebinger, Torgil Elias Friman

Mitotic bookmarking transcription factors remain bound to chromosomes during mitosis and were proposed to regulate phenotypic maintenance of stem and progenitor cells at the mitosis-to-G1 (M-G1) transition. However, mitotic bookmarking remains largely unex ...

Cold Spring Harbor Laboratory2016