Vincent Roland Julien Gardeux

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Publications associées (28)

Sex-dependent and sex-independent regulatory systems of size variation in natural populations

Bart Deplancke, Ernst Hafen, Vincent Roland Julien Gardeux

Size of organs/organisms is a polygenic trait. Many of the growth-regulatory genes constitute conserved growth signaling pathways. However, how these multiple genes are orchestrated at the systems level to attain the natural variation in size including sex ...

2019

Epigenomic landscape defines immuno-modulatory properties across lymph node stromal cell subsets

Bart Deplancke, Vincent Roland Julien Gardeux, Maria Litovchenko, Jörn Pezoldt

WILEY2019

Dynamic regulation of chromatin accessibility by pluripotency transcription factors across the cell cycle

Cédric Deluz, Bart Deplancke, David Michael Suter, Antonio Carlos Alves Meireles Filho, Torgil Elias Friman, Vincent Roland Julien Gardeux, Subashika Govindan

The pioneer activity of transcription factors allows for opening of inaccessible regulatory elements and has been extensively studied in the context of cellular differentiation and reprogramming. In contrast, the function of pioneer activity in self-renewi ...

2019

OCT4 and SOX2 are required at the M-G1 transition to re-establish chromatin accessibility at enhancers in pluripotent stem cells

Cédric Deluz, David Michael Suter, Antonio Carlos Alves Meireles Filho, Torgil Elias Friman, Vincent Roland Julien Gardeux

MARY ANN LIEBERT, INC2018

Dissecting the brown adipogenic regulatory network using integrative genomics

Bart Deplancke, Sunil Kumar Raghav, Rachana Narendra Pradhan, Petra Catalina Schwalie, Julie Marie Russeil, Wanze Chen, Daniel Alpern, Vincent Roland Julien Gardeux, Johannes Julius Bues

Brown adipocytes regulate energy expenditure via mitochondrial uncoupling, which makes them attractive therapeutic targets to tackle obesity. However, the regulatory mechanisms underlying brown adipogenesis are still poorly understood. To address this, we ...

Springer Nature2017

ASAP: a web-based platform for the analysis and interactive visualization of single-cell RNA-seq data

Bart Deplancke, Adrian Shajkofci, Petra Catalina Schwalie, Vincent Roland Julien Gardeux

Motivation: Single-cell RNA-sequencing (scRNA-seq) allows whole transcriptome profiling of thousands of individual cells, enabling the molecular exploration of tissues at the cellular level. Such analytical capacity is of great interest to many research gr ...

Oxford University Press2017

Profiling of Single-Cell Transcriptomes

Bart Deplancke, Antonio Carlos Alves Meireles Filho, Wanze Chen, Vincent Roland Julien Gardeux

Complex biological systems are composed of multiple cell types whose transcriptional activity can vary due to differences in cell state, environmental stimulation or intrinsic programs. Conventional bulk analysis methods capture the average transcriptional ...

2017

The Genetics of Transcription Factor DNA Binding Variation

Bart Deplancke, Daniel Alpern, Vincent Roland Julien Gardeux

Most complex trait-associated variants are located in non-coding regulatory regions of the genome, where they have been shown to disrupt transcription factor (TF)-DNA binding motifs. Variable TF-DNA interactions are therefore increasingly considered as key ...

Elsevier2016

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