Publications de Arin Can Ülkü

Beneath the surface: revealing deep-tissue blood flow in human subjects with massively parallelized diffuse correlation spectroscopy

Claudio Bruschini, Edoardo Charbon, Arin Can Ülkü, Michael Alan Wayne

Significance: Diffuse correlation spectroscopy (DCS) allows label-free, non-invasive investigation of microvascular dynamics deep within tissue, such as cerebral blood flow (CBF). However, the signal-to-noise ratio (SNR) in DCS limits its effective cerebra ...

SPIE-Intl Soc Optical Eng2025

Subsurface fluorescence time-of-flight imaging using a large-format single-photon avalanche diode sensor for tumor depth assessment

Claudio Bruschini, Edoardo Charbon, Arin Can Ülkü, Yichen Feng

Significance: Fluorescence guidance is used clinically by surgeons to visualize anatomical and/or physiological phenomena in the surgical field that are difficult or impossible to detect by the naked eye. Such phenomena include tissue perfusion or molecula ...

SPIE Society of Photo-optical Instrumentation Engineers2024

SwissSPAD2/3: a family of natively digital, time gated SPAD cameras with continuous streaming at up to 100 kpfs and picosecond system-level synchronization for quantum imaging applications

Claudio Bruschini, Edoardo Charbon, Arin Can Ülkü, Andrei Ardelean, Paul Mos

The SwissSPAD2/3 camera family is based on quarter megapixel single-photon avalanche diode (SPAD) time gated imagers. The 16.38-µm low-noise pixels feature a single-bit memory and built-in all-solid-state nanosecond time gating without the need for externa ...

SPIE2024

Temporal Point Spread Function Deconvolution in Time-resolved Fluorescence Lifetime Imaging using Deep Learning Model

Claudio Bruschini, Edoardo Charbon, Arin Can Ülkü

We report a deep RNN model for temporal point spread function (TPSFs) deconvolution in multimodal imaging systems to extract true sample fluorescence decay rate. It’s performance has been validated in phantom and well-plate data. ...

Optical Society of America2024

Deep learning-based temporal deconvolution for photon time-of-flight distribution retrieval

Claudio Bruschini, Edoardo Charbon, Arin Can Ülkü

The acquisition of the time of flight (ToF) of photons has found numerous applications in the biomedical field. Over the last decades, a few strategies have been proposed to deconvolve the temporal instrument response function (IRF) that distorts the exper ...

2024

GPU-based data processing for speeding-up correlation plenoptic imaging

Claudio Bruschini, Edoardo Charbon, Samuel Burri, Arin Can Ülkü, Paul Mos, Michael Alan Wayne

Correlation plenoptic imaging (CPI) is a novel technological imaging modality enabling to overcome drawbacks of standard plenoptic devices, while preserving their advantages. However, a major challenge in view of real-time application of CPI is related to ...

2024

Time-resolved Laser Speckle Contrast Imaging (TR-LSCI) of Cerebral Blood Flow

Claudio Bruschini, Edoardo Charbon, Arin Can Ülkü, Paul Mos

To address many of the deficiencies in optical neuroimaging technologies, such as poor tempo-spatial resolution, low penetration depth, contact-based measurement, and time-consuming image reconstruction, a novel, noncontact, portable, time-resolved laser s ...

Institute of Electrical and Electronics Engineers2024

3D fluorescence molecular tomography utilizing a novel SPAD camera

Claudio Bruschini, Edoardo Charbon, Vikash Kumar Pandey, Arin Can Ülkü

3D Fluorescence Molecular Tomography (FMT) is an important pre-clinical tool for quantifying and characterizing molecular markers for different diseases. Herein, we demonstrate, for the first time, 3D K-Space FMT reconstructions using a large time-gated SP ...

SPIE2024

Heralded Spectroscopy: a new single-particle probe for nanocrystal photophysics

Claudio Bruschini, Edoardo Charbon, Samuel Burri, Ivan Michel Antolovic, Arin Can Ülkü

Semiconductor nanocrystals feature multiply-excited states that display intriguing physics and significantly impact nanocrystal-based technologies. Fluorescence supplies a natural probe to investigate these states. Still, direct observation of multiexciton ...

SPIE2023

Correlated-photon imaging at 10 volumetric images per second

Claudio Bruschini, Edoardo Charbon, Arin Can Ülkü, Paul Mos

The correlation properties of light provide an outstanding tool to overcome the limitations of traditional imaging techniques. A relevant case is represented by correlation plenoptic imaging (CPI), a quantum-inspired volumetric imaging protocol employing s ...

Nature Portfolio2023

Method and device for performing spectrally and temporally resolved spectroscopy of single photon emission in a quantum device

Claudio Bruschini, Edoardo Charbon, Arin Can Ülkü

A light spectrometer including a laser configured to provide for a laser pulse (12), a quantum dot (30), an objective (21) configured to focus the laser pulse (12) onto the quantum dot (30) such that a fluorescent light beam is emitted from the quantum dot ...

2023

LinoSPAD2: a 512x1 linear SPAD camera with system-level 135-ps SPTR and a reconfigurable computational engine for time-resolved single-photon imaging

Claudio Bruschini, Edoardo Charbon, Samuel Burri, Arin Can Ülkü, Tommaso Milanese

The LinoSPAD2 camera combines a 512×1 linear single-photon avalanche diode (SPAD) array with an FPGA-based photon-counting and time-stamping platform, to create a reconfigurable sensing system capable of detecting single photons. The read-out is fully para ...

SPIE2023

Massively parallel, real-time multispeckle diffuse correlation spectroscopy using a 500 × 500 SPAD camera

Claudio Bruschini, Edoardo Charbon, Francesco Marsili, Arin Can Ülkü, Andrei Ardelean, Paul Mos, Michael Alan Wayne

Diffuse correlation spectroscopy (DCS) is a promising noninvasive technique for monitoring cerebral blood flow and measuring cortex functional activation tasks. Taking multiple parallel measurements has been shown to increase sensitivity, but is not easily ...

2023

NIR Fluorescence lifetime macroscopic imaging with a time-gated SPAD camera

Claudio Bruschini, Edoardo Charbon, Arin Can Ülkü

The performance of SwissSPAD2 (SS2), a large scale, widefield time-gated CMOS SPAD imager developed for fluorescence lifetime imaging, has recently been described in the context of visible range and fluorescence lifetime imaging microscopy (FLIM) of dyes w ...

SPIE-INT SOC OPTICAL ENGINEERING2022

In vitro and in vivo NIR fluorescence lifetime imaging with a time-gated SPAD camera

Claudio Bruschini, Edoardo Charbon, Arin Can Ülkü

Near-infrared (NIR) fluorescence lifetime imaging (FLI) provides a unique contrast mechanism to monitor biological parameters and molecular events in vivo. Single-photon avalanche diode (SPAD) cameras have been recently demonstrated in FLI microscopy (FLIM ...

Optica Publishing Group2022

Light detection and ranging with entangled photons

Edoardo Charbon, Arin Can Ülkü, Jiuxuan Zhao

Single-photon light detection and ranging (LiDAR) is a key technology for depth imaging through complex environments. Despite recent advances, an open challenge is the ability to isolate the LiDAR signal from other spurious sources including background lig ...

OPTICAL SOC AMER2022

Using Heralded Spectrometry to Measure the Biexciton Binding Energy of an Individual Quantum Dot

Claudio Bruschini, Edoardo Charbon, Samuel Burri, Ivan Michel Antolovic, Arin Can Ülkü

Spectrometry of a quantum state of light is a fundamental challenge with practical implications. Here, we demonstrate how such a technique can super-resolve the exciton and biexciton energies in a single quantum dot at room temperature. ...

Optica2022

A 500 x 500 Dual-Gate SPAD Imager With 100% Temporal Aperture and 1 ns Minimum Gate Length for FLIM and Phasor Imaging Applications

Claudio Bruschini, Edoardo Charbon, Arin Can Ülkü, Andrei Ardelean, Paul Mos, Michael Alan Wayne

In this article, we report on SwissSPAD3 (SS3), a 500 x 500 pixel single-photon avalanche diode (SPAD) array, fabricated in 0.18-mu m CMOS technology. In this sensor, we introduce a novel dual-gate architecture with two contiguous temporal windows, or gate ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2022

Characterization of a large gated SPAD array for widefield NIR fluorescence lifetime imaging in vitro and in vivo

Claudio Bruschini, Edoardo Charbon, Arin Can Ülkü

CELL PRESS2022

Towards Quantum 3D Imaging Devices

Claudio Bruschini, Edoardo Charbon, Samuel Burri, Arin Can Ülkü, Paul Mos, Michael Alan Wayne

We review the advancement of the research toward the design and implementation of quantum plenoptic cameras, radically novel 3D imaging devices that exploit both momentum–position entanglement and photon–number correlations to provide the typical refocusin ...

2021