Publications associées à Dependence of the spike-triggered average voltage on membrane response properties

Membrane specificity of the human cholesterol transfer protein STARD4

STARD4 regulates cholesterol homeostasis by transferring cholesterol between the plasma membrane and endoplasmic reticulum. The STARD4 structure features a helix-grip fold surrounding a large hydrophobic cavity holding the sterol. Its access is controlled ...

Academic Press Ltd- Elsevier Science Ltd2024

S-acylation and lipid exchange at the ER-Golgi membrane contact sites regulate pathogen entry in human cells

Muhammad Umair Anwar

Cells have evolved endocytic pathways to internalize different molecules, to regulate intra-cellular communication and their interaction with external environment. Pathogens have co-evolved with cells to exploit these processes for infections. In particula ...

EPFL2024

From Surfactants to 3D Printing: How Ion-Chelator Pair Interactions Affect the Mechanical Properties of Bioinspired Materials

Gaia De Angelis

The remarkable adaptability observed in marine ecosystems has often inspired researchers when developing new soft materials. The research undertaken in this thesis explores how ion chelator pair interactions influence the mechanical properties of bioinspir ...

EPFL2024

Global existence for perturbations of the 2D stochastic Navier-Stokes equations with space-time white noise

Martin Hairer

We prove global in time well-posedness for perturbations of the 2D stochastic Navier-Stokes equations partial derivative( t)u + u center dot del u = Delta u - del p + sigma + xi, u(0, center dot ) = u(0),div (u) = 0, driven by additive space-time white noi ...

Springernature2024

Large Libraries of Structurally Diverse Macrocycles Suitable for Membrane Permeation

Christian Heinis, Alessandro Angelini, Mischa Schüttel, Ganesh Kumar Mothukuri, Manuel Leonardo Merz, Zsolt Bognár, Xinjian Ji, Edward Jeffrey Will, Alexander Lund Nielsen, Anne Sofie Luise Zarda

Macrocycles offer an attractive format for drug development due to their good binding properties and potential to cross cell membranes. To efficiently identify macrocyclic ligands for new targets, methods for the synthesis and screening of large combinator ...

Wiley-VCH Verlag GmbH2024

Fast adaptation to rule switching using neuronal surprise

Wulfram Gerstner, Martin Louis Lucien Rémy Barry

In humans and animals, surprise is a physiological reaction to an unexpected event, but how surprise can be linked to plausible models of neuronal activity is an open problem. We propose a self-supervised spiking neural network model where a surprise signa ...

2024

Predicting Visual Stimuli From Cortical Response Recorded With Wide-Field Imaging in a Mouse

Silvestro Micera, Daniela De Luca

Neural decoding of the visual system is a subject of research interest, both to understand how the visual system works and to be able to use this knowledge in areas, such as computer vision or brain-computer interfaces. Spike-based decoding is often used, ...

Ieee-Inst Electrical Electronics Engineers Inc2024

Subcortical correlates of consciousness with human single neuron recordings

Michael Eric Anthony Pereira, Olaf Blanke, Nathan Quentin Faivre, Fosco Bernasconi

Subcortical brain structures such as the basal ganglia or the thalamus are involved in regulating motor and cognitive behavior. However, their contribution to perceptual consciousness is still unclear, due to the inherent difficulties of recording subcorti ...

2024

Effects of thermal, mechanical, and electrostatic perturbations on lipid membrane hydration investigated by second harmonic imaging

Seonwoo Lee

Hydrated lipid bilayer membranes are crucial components of cells and organelles, serving as the outer boundary that separates the cellular components from the extracellular environment. Lipid membranes regulate their structures and functions by dynamically ...

EPFL2023

Data for: "A Neural-Network-Based Convex Regularizer for Inverse Problems"

Michaël Unser, Stanislas Ducotterd, Pakshal Narendra Bohra, Alexis Marie Frederic Goujon, Sebastian Jonas Neumayer

Data for: "A Neural-Network-Based Convex Regularizer for Inverse Problems". The corresponding scripts can be accessed on GitHub (https://github.com/axgoujon/convex_ridge_regularizers). The data is organized as follows: - ct_data_sets.tar.gz: contains prepr ...

Zenodo2023

Principles of Network Plasticity in Neocortical Microcircuits

András Ecker

Synaptic plasticity underlies our ability to learn and adapt to the constantly changing environment. The phenomenon of synapses changing their efficacy in an activity-dependent manner is often studied in small groups of neurons in vitro or indirectly throu ...

EPFL2023

High throughput wide field second harmonic imaging of giant unilamellar vesicles

Sylvie Roke, Pierre-Marc Jean Marie Dansette, Maksim Eremchev, David Roesel

Cell-sized giant unilamellar vesicles (GUVs) are an ideal tool for understanding lipid membrane structure and properties. Label-free spatiotemporal images of their membrane potential and structure would greatly aid the quantitative understanding of membran ...

AIP Publishing2023

Simultaneous membrane and RNA binding by Tick-Borne Encephalitis Virus capsid protein

Sarah Victoria Barrass

Tick-borne encephalitis virus is an enveloped, pathogenic, RNA virus in the family Flaviviridae, genus Flavivirus. Viral particles are formed when the nucleocapsid, consisting of an RNA genome and multiple copies of the capsid protein, buds through the end ...

PUBLIC LIBRARY SCIENCE2023

Assemblies, synapse clustering and network topology interact with plasticity to explain structure-function relationships of the cortical connectome

James Gonzalo King, Eilif Benjamin Muller, Michael Reimann, Marwan Muhammad Ahmed Abdellah, Giuseppe Chindemi, Pramod Shivaji Kumbhar, András Ecker, Daniela Egas Santander, Ioannis Magkanaris, Sirio Bolaños Puchet, Jorge Blanco Alonso, James Bryden Isbister

Synaptic plasticity underlies the brain’s ability to learn and adapt. While experiments in brain slices have revealed mechanisms and protocols for the induction of plasticity between pairs of neurons, how these synaptic changes are coordinated in biologica ...

2024

On a Finite-Size Neuronal Population Equation

Valentin Marc Schmutz, Tilo Schwalger, Eva Löcherbach

Population equations for infinitely large networks of spiking neurons have a long tradition in theoret-ical neuroscience. In this work, we analyze a recent generalization of these equations to populations of finite size, which takes the form of a nonlinear ...

SIAM PUBLICATIONS2023

Simultaneous Electrophysiology and Imaging Reveal Changes in Lipid Membrane Thickness and Tension upon Uptake of Amphiphilic Gold Nanoparticles

Francesco Stellacci, Paulo Henrique Jacob Silva, Camilla Servidio, Xufeng Xu

Amphiphilic gold core nanoparticles (AmNPs) striped with hydrophilic 11-mercapto-1-undecanesulfonate (MUS) and hydrophobic 1-octanethiol (OT) ligands are promising candidates for drug carriers that passively and nondisruptively enter cells. Yet, how they i ...

Amer Chemical Soc2023

Modeling and simulation of neocortical micro- and mesocircuitry. Part II: Physiology and experimentation

Henry Markram, Felix Schürmann, James Gonzalo King, Rajnish Ranjan, Srikanth Ramaswamy, Alexis Arnaudon, Eilif Benjamin Muller, Daniel Keller, Michael Reimann, Vishal Sood, Jean-Denis Georges Emile Courcol, Werner Alfons Hilda Van Geit, Giuseppe Chindemi, Michael Emiel Gevaert, Pramod Shivaji Kumbhar, Armando Romani, Christian Andreas Rössert, Judit Planas Carbonell, Genrich Ivaska, András Ecker, Daniela Egas Santander, Natali Barros Zulaica, Alexander Dietz, Omar Awile, Samuel Lieven D. Lapere, Matthias Wolf, Sirio Bolaños Puchet, Thomas Brice Delemontex, Jorge Blanco Alonso, Mustafa Anil Tuncel, Tanguy Pierre Louis Damart, Maria Reva, James Bryden Isbister, Darshan Mandge, Weina Ji, Aleksandra Zuzanna Teska, Polina Litvak, Gianluca Ficarelli, Joni Henrikki Herttuainen, ,

Disentangling 1/f noise from confined ion dynamics

Théo Denis Tobias Emmerich

Ion transport through biological and solid-state nanochannels is known to be a highly noisy process. The power spectrum of current fluctuations is empirically known to scale like the inverse of frequency, following the long-standing yet poorly understood H ...

ROYAL SOC CHEMISTRY2023

Structure of a membrane-bound menaquinol:organohalide oxidoreductase

Henning Paul-Julius Stahlberg, Christof Holliger, Julien Maillard, Lorenzo Cimmino, Dongchun Ni, Babatunde Edukpe Ekundayo

Organohalide-respiring bacteria are key organisms for the bioremediation of soils and aquifers contaminated with halogenated organic compounds. The major players in this process are respiratory reductive dehalogenases, corrinoid enzymes that use organohali ...

Nature Research2023

Capturing Types

Martin Odersky, Ondrej Lhoták, Aleksander Slawomir Boruch-Gruszecki

Type systems usually characterize the shape of values but not their free variables. However, many desirable safety properties could be guaranteed if one knew the free variables captured by values. We describe CC

Assoc Computing Machinery2023