Publications associées à Design, Synthesis and in vitro Controlled Release of New Adamantanodiarylketone Antimycobacterials

IMPROVED REGULARITY OF SECOND DERIVATIVES FOR SUBHARMONIC FUNCTIONS

Riccardo Tione, Xavier Fernandez-Real Girona

In this note, we prove that if a subharmonic function Delta u >= 0 has pure second derivatives partial derivative(ii)u that are signed measures, then their negative part (partial derivative(ii)u)- belongs to L-1 (in particular, it is not singular). We then ...

Amer Mathematical Soc2023

Repurposed drug combination via high-throughput screening and dual drug delivery system development for the treatment of retinoblastoma

Po-Jen Tseng

The goal of retinoblastoma (RB) treatment is to save the child's life, eyes and functional vision, with that order of priority. The management of RB is complex and involves strategically chosen methods of surgical enucleation, external beam radiotherapy, i ...

EPFL2022

Stochastic derivative estimation for max-stable random fields

Erwan Fabrice Koch

We consider expected performances based on max-stable random fields and we are interested in their derivatives with respect to the spatial dependence parameters of those fields. Max-stable fields, such as the Brown-Resnick and Smith fields, are very popula ...

ELSEVIER2022

A computational workflow for the expansion of heterologous biosynthetic pathways to natural product derivatives

Vassily Hatzimanikatis, Jasmin Maria Hafner

Plant natural products (PNPs) and their derivatives are important but underexplored sources of pharmaceutical molecules. To access this untapped potential, the reconstitution of heterologous PNP biosynthesis pathways in engineered microbes provides a valua ...

Nature Research2021

Polarity Of Almost All Points For Systems Of Nonlinear Stochastic Heat Equations In The Critical Dimension

Robert Dalang

We study vector-valued solutions u(t, x) is an element of R-d to systems of nonlinear stochastic heat equations with multiplicative noise, ...

INST MATHEMATICAL STATISTICS-IMS2021

Towards the Development of Orally Available Peptide Therapeutics

Christian Heinis, Xudong Kong

Peptides have a number of attractive properties that make them an interesting modality for drug development, including their ability to bind challenging targets, their high target specificity, and their non-toxic metabolic products. However, a major limita ...

2021

Fabrication of micrometer-sized drops as templates for particles

Mathias Steinacher

Drops are omnipresent in our daily life for example in the form of rain drops or as oil drops in a salad dressing. On a technological basis, drops can be used to conduct chemical or biological reactions. These drops often serve as templates to produce mate ...

EPFL2021

On design strategies for binary dielectric metasurfaces based on the Fourier modal method

Kévin Müller

Binary dielectric metasurfaces are arrays of sub-wavelength structures that act as a thin layer of artificial material. They are generally lossless and relatively simple to fabricate since only a single structuring step is required. By carefully designing ...

EPFL2020

Local Non-Rigid Structure-from-Motion from Locally Diffeomorphic Mappings

Pascal Fua, Mathieu Salzmann, Shaifali Parashar

We propose a new formulation to the non-rigid structure-from-motion problem that only requires the deforming surface to meaning that its differential structure is preserved. This is a much weaker assumption than the traditional ones of isometry or conforma ...

2020

Catechol Containing Polyelectrolyte Complex Nanoparticles as Local Drug Delivery System for Bortezomib at Bone Substitute Materials

Martin Guillermo Mueller, Jeremy Pak Hei Wong

The proteasome inhibitor bortezomib (BZM) is one of the most potent anti-cancer drugs in the therapy of multiple myeloma. In this study, an adhesive drug delivery system (DDS) for BZM was developed. Therefore, we extended the present DDS concept of polyele ...

2020

A critically degenerate elliptic Dirichlet problem, spectral theory and bifurcation

Charles Stuart

In an open, bounded subset Omega of R-N such that 0 is an element of Omega we consider the nonlinear eigenvalue problem -Sigma(N)(i,j,=1) partial derivative(i){A(ij)(x)partial derivative(j)u} + V(x)u + n(x,del u)+ g(x, u) = lambda u in Omega integral(Omega ...

2020

On the choice of metric in gradient-based theories of brain function

Wulfram Gerstner, Jean-Pascal Théodor Pfister, Johanni Michael Brea

The idea that the brain functions so as to minimize certain costs pervades theoretical neuroscience. Because a cost function by itself does not predict how the brain finds its minima, additional assumptions about the optimization method need to be made to ...

2020

Optimal Spline Generators for Derivative Sampling

Michaël Unser, Shayan Aziznejad, Alireza Naderi

The goal of derivative sampling is to reconstruct a signal from the samples of the function and of its first-order derivative. In this paper, we consider this problem over a shift-invariant reconstruction subspace generated by two compact-support functions ...

IEEE2019

In vitro Controlled Release from Solid Pharmaceutical Formulations of two new Adamantane Aminoethers with Antitubercular Activity (I)

Stewart Cole, Anthony Vocat

The aim of the present investigation was to develop matrix tablet formulations for the in vitro controlled release of 2 new tuberculocidal adamantane aminoethers (compounds I and II), congeneric to the adamantane derivative SQ109 , which is in final clinic ...

Georg Thieme Verlag Kg2017

Contributions to Modelling Extremes of Spatial Data

Linda Frossard

The increasing interest in using statistical extreme value theory to analyse environmental data is mainly driven by the large impact extreme events can have. A difficulty with spatial data is that most existing inference methods for asymptotically justifie ...

EPFL2017

Noether Theorems and Quantum Anomalies

Tudor Ratiu

A quantum anomaly is the breaking of symmetry with respect to some transformations after the quantization of a classical Hamiltonian or Lagrangian system. It is shown that both the Noether theorems (including their infinite-dimensional versions) and the ex ...

Springer Verlag2017

Benzothiophene, benzyloxybenzylidene and indoline derivatives useful for the treatment of tuberculosis

Stewart Cole, Jan Lars Rybniker

The present invention relates to benzothiophene, benzyloxybenzylidene and indoline-2-one derivatives and the use of said derivatives in the treatment and/or prevention of tuberculosis. ...

2016

2-homopiperazine-1-yl-4h-1,3-benzothiazine-4-one derivatives and process for the preparation of 2- (homo)piperazine 1,3-benzothiazine-4-one hydrochlorides

2-homopiperazine-1-yl-4H-l, 3 -bensothiazine-4-one derivatives of formula (I) are provided. They are useful in the treatment of bacterial infections, in particular tuberculosis, buruli ulcer and leprosy. A process for the preparation of 2- (homo)piperazine ...

2016

Bifurcation without Frechet differentiability at the trivial solution

Charles Stuart

Criteria for the bifurcation of small solutions of an equation F(lambda,u) = 0 from a line {(lambda,0): lambda is an element of R} of trivial solutions are usually based on properties of the DuF(lambda,0) at the trivial solutions, where the partial derivat ...

Wiley-Blackwell2015

Discontinuous Galerkin method for fractional convection-diffusion equations

Jan Sickmann Hesthaven

We propose a discontinuous Galerkin method for convection-subdiffusion equations with a fractional operator of order alpha [1,2] defined through the fractional Laplacian. The fractional operator of order alpha is expressed as a composite of first order der ...

Society for Industrial and Applied Mathematics2014