Publications associées à A Versatile Synthetic Path to Thiol Containing Polysiloxanes

Methods for high-throughput synthesis and screening of peptide libraries

Macrocycles provide an attractive modality for drug development but the identification of ligands to targets of interest is hindered by the lack of large macrocyclic compound libraries for high-throughput screening. A strategy to efficiently synthesize lar ...

EPFL2024

The Structural Dispersity of Oligoethylene Glycol-Containing Polymer Brushes Determines Their Interfacial Properties

Harm-Anton Klok, Alberto Ongaro, Irene Filipucci

Ought to their bioinert properties and facile synthesis, poly[(oligoethylene glycol)methacrylate]s (POEGMAs) have been raised as attractive alternatives to poly(ethylene glycols) (PEGs) in an array of (bio)material applications, especially when they are ap ...

Amer Chemical Soc2024

Supramolecular Modifications of Semicrystalline Polymers

Michael Alan Giffin

Supramolecular interactions play an important role in defining the structure and the resulting mechanical properties of materials. For instance, interchain hydrogen-bonding in PAs gives them superior strength and stiffness in engineering materials, while t ...

EPFL2023

High-Density Immobilization of TCEP on Silica Beads for Efficient Disulfide Reduction and Thiol Alkylation in Peptides

Christian Heinis

Tris-(2-carboxyethyl)phosphine (TCEP) linked to agarose beads is widely used for reducing disulfide bridges in proteins and peptides. The immobilization of TCEP on beads allows efficient removal after reduction to prevent its reaction with alkylating reage ...

2023

Tailor-made Piezoelectric Elastomer Materials

Francis Owusu

Recent advancements in miniature devices with higher computational capabilities and ultralow power consumption have accelerated the development of wearable sensors, actuators, and energy harvesters everywhere. The ultimate aim of such a technological revol ...

EPFL2023

Recyclable flame retardant phosphonated epoxy based thermosets enabled via a reactive approach

Véronique Michaud, Valentin Rougier

The development of reusable fire-safe polymers with a prolonged lifetime heralds the switch for a transition towards circular economy. In this framework, we report a novel phosphonated thermoset which is composed of networked phosphonate esters containing ...

ELSEVIER SCIENCE SA2023

Reinforced Supramolecular Networks of End Functionalized Polymers for Tailored Thermomechanical Property Profiles

Yevhen Hryshunin

Thermoset rubbers give rise to elastomers with tunable stiffness and high resilience but are not recyclable. Thermoplastic elastomers can address this problem but their broad applicability is impeded by either limited operating temperatures or inferior ela ...

EPFL2023

Solid-phase peptide synthesis on disulfide-linker resin followed by reductive release affords pure thiol-functionalized peptides

Christian Heinis, Ganesh Kumar Mothukuri, Manuel Leonardo Merz, Zsolt Bognár, Peter Matei Frisius Pânzar, Alexander Lund Nielsen

Thiol groups are suitable handles for site-selectively modifying, immobilizing or cyclizing individual peptides or entire peptide libraries. A limiting step in producing the thiol-functionalized peptides is the chromatographic purification, which is partic ...

2022

High Permittivity Siloxanes as Promising Materials for Dielectric Elastomer Transducers: From Synthesis to Application

Yauhen Sheima

The speed of change in the modern world is impressive. Within the last 50 years, many devices and technologies have significantly transformed their appearance, intrinsic characteristics and improved their performance. Computers have changed from the size o ...

EPFL2022

Extraction and controlled functionalization of lignin for materials applications

Stefania Bertella

Lignin is a renewable aromatic polymer that due to its abundance and unique chemical structure is a promising candidate to replace aromatic materials that are currently sourced from fossil oil. The same structure of lignin poses however drawbacks for its v ...

EPFL2022

Fluorinated Tetraarylethenes: Universal Tags for the Synthesis of Solid State Luminogens

Kay Severin, Rosario Scopelliti, Euro Solari, Albert Ruggi, Farzaneh Fadaei Tirani, Abdusalom Suleymanov, Thibault Jacques Marie Damiens Vanrapenbusch, Barbara Maja Kraus

The aggregation-induced emission properties of tetraarylethenes (TAEs) have led to numerous applications in chemistry, biology, and materials science. Herein, we describe two fluorinated tetraarylethenes, which can be employed as universal tags for the syn ...

Wiley-VCH Verlag GmbH2022

Cyclic Behaviour of Unidirectional Hybrid Interlayer Glass/Carbon and Carbon/Carbon Composites

Anastasios Vassilopoulos, José Manuel de Sena Cruz

The lack of ductility is a major drawback of fibre reinforced polymer (FRP) materials. As it is known, these materials are stiff and strong, but brittle with little or no warning before final failure. In the last decades, some solutions have been proposed ...

SPRINGER-VERLAG SINGAPORE PTE LTD2022

From vesicles to materials: bioinspired strategies for fabricating hierarchically structured soft matter

Esther Amstad

Certain organisms including species of mollusks, polychaetes, onychophorans and arthropods produce exceptional polymeric materials outside their bodies under ambient conditions using concentrated fluid protein precursors. While much is understood about the ...

ROYAL SOC2021

Reversible and Broad-Range Oxygen Sensing Based on Purely Organic Long-Lived Photoemitters

Esther Amstad, Efe Armagan, René M. Rossi

The detection of oxygen (O-2) by optical sensors is of growing importance, for example, in biology, life science, environmental science, and aerodynamics, where the composition of gases is crucial for many applications. Purely organic optical O-2 sensors a ...

2021

Stiff, Strong, Tough, and Highly Stretchable Hydrogels Based on Dual Stimuli-Responsive Semicrystalline Poly(urethane–urea) Copolymers

Pascal Alexander Schouwink, Nicolas Candau, Adrien Julien Demongeot, Oguzhan Oguz

There has been a considerable interest in developing stiff, strong, tough, and highly stretchable hydrogels in various fields of science and technology including biomedical and sensing applications. However, simultaneous optimization of stiffness, strength ...

2021

Increased electromechanical sensitivity of polysiloxane elastomers by chemical modification with thioacetic groups

Yee Song Ko

Chemically cross-linked polydimethylsiloxane (PDMS) elastomers have gained importance as a dielectric in elastic capacitor actuators, which elongate when electrically charged. Common PDMS elastomers have a dielectric permittivity of only about 3 and thus e ...

2020

Reversibly Cross-Linking Polymer Brushes Using Interchain Disulfide Bonds

Harm-Anton Klok, Piotr Mocny

The introduction of interchain cross-links in surface-grafted polymer brushes increases the robustness and mechanical properties of these thin polymer films. In most cases, cross-linked polymer brushes contain permanent interchain cross-links. The use of r ...

American Chemical Society2020

Mechanical and Morphological Properties of Lignin-Based Thermosets

Cédric Terrier

The need for renewable alternatives for fossil-based aromatic material constituents is evident for a more sustainable society. Lignin is the largest source of naturally occurring aromatic compounds but has mainly been considered as waste material or energy ...

2020

Towards the Sarpagine-Ajmaline-Macroline Family of Indole Alkaloids: Enantioselective Synthesis of an N-Demethyl Alstolactone Diastereomer

Qian Wang, Jieping Zhu, Dylan Jean Robert Dagoneau

the strategy involving the use of functionalized tetrahydro-6H-cycloocta[b]indol-6-one is reported as a key intermediate for synthesis of members of the sarpagine-ajmaline-macroline family of monoterpene indole alkaloids. The desired tricycle was synthesiz ...

WILEY-V C H VERLAG GMBH2020

Advancing computational and data-driven methods for the design and discovery of nanoporous materials

Seyedmohamad Moosavi

Metal-organic framework (MOFs) and related nanoporous materials have emerged as promising candidates for a variety of applications, such as gas separation and storage, catalysis, sensing, etc. Their building block structure allows us to generate a huge num ...

EPFL2020