Publications associées à Nicotine increases sleep spindle activity

Anthony C Davison and Igor Rodionov's contribution to the Discussion of 'Estimating means of bounded random variables by betting' by Waudby-Smith and Ramdas

Anthony Christopher Davison, Igor Rodionov

We derive confidence intervals (CIs) and confidence sequences (CSs) for the classical problem of estimating a bounded mean. Our approach generalizes and improves on the celebrated Chernoff method, yielding the best closed-form "empirical-Bernstein" CSs and ...

Oxford Univ Press2024

Mechanistic Understanding of Neurobehavioral Effects of Insecticides on the Larvae of Zebrafish (Danio rerio)

Sarah-Katharina Könemann

Due to conservation of neuronal functioning across phyla, molecular targets of insecticides are similar in insects and vertebrates. Insecticides thus pose a risk to aquatic vertebrates, such as fish, and potentially cause neurotoxic effects. Although these ...

EPFL2022

Neuromodulation of neocortical microcircuitry: a multi-scale framework to model the effects of cholinergic release

Cristina Colangelo

Neuromodulation of neocortical microcircuits is one of the most fascinating and mysterious aspects of brain physiology. Despite over a century of research, the neuroscientific community has yet to uncover the fundamental biological organizing principles un ...

EPFL2022

Preliminary evidence that daily light exposure enhances the antibody response to influenza vaccination in patients with dementia

Jean-Louis Scartezzini

Enhancing lighting conditions in institutions for individuals with dementia improves their sleep, circadian rhythms and well-being. Here, we report first findings that exposure to brighter light during daytime may support the immune response to the annual ...

ELSEVIER2022

Genetic selection for low glucocorticoid responsiveness recapitulates PTSD-related phenotypes: a behavioral, neuroimaging and sleep-physiology study

Silvia Monari

Humans show inter-individual differences in vulnerability to develop post-traumatic stress disorder (PTSD) following exposure to trauma. Several critical biobehavioral features have been consistently described in PTSD patients, including blunted cortisol l ...

EPFL2022

Is There a Cap on Longevity? A Statistical Review

Anthony Christopher Davison, Léo Raymond-Belzile

There is sustained and widespread interest in understanding the limit, if there is any, to the human life span. Apart from its intrinsic and biological interest, changes in survival in old age have implications for the sustainability of social security sys ...

ANNUAL REVIEWS2022

A note on universal inference

Anthony Christopher Davison, Timmy Rong Tian Tse

Universal inference enables the construction of confidence intervals and tests without regularity conditions by splitting the data into two parts and appealing to Markov's inequality. Previous investigations have shown that the cost of this generality is a ...

WILEY2022

REM sleep and muscle atonia in brainstem stroke: A quantitative polysomnographic and lesion analysis study

Lukas Heydrich, Eva Blondiaux

Important brainstem regions are involved in the regulation of rapid eye movement sleep. We hypothesized that brainstem stroke is associated with dysregulated rapid eye movement sleep and related muscle activity. We compared quantitative/qualitative polysom ...

WILEY2022

Cell-type-specific nicotinic input disinhibits mouse barrel cortex during active sensing

Carl Petersen, Sylvain Crochet, Célia Roxane Gasselin, Benoît Hohl

Fast synaptic transmission relies upon the activation of ionotropic receptors by neurotransmitter release to evoke postsynaptic potentials. Glutamate and GABA play dominant roles in driving highly dynamic activity in synaptically connected neuronal circuit ...

CELL PRESS2021

Contactless Sleep Monitoring for Early Detection of Health Deteriorations in Community-Dwelling Older Adults: Exploratory Study

Philipp Buluschek, Daniel Gatica-Perez, Bruno Pais

Background: Population aging is posing multiple social and economic challenges to society. One such challenge is the social and economic burden related to increased health care expenditure caused by early institutionalizations. The use of modern pervasive ...

JMIR PUBLICATIONS, INC2021

Asymmetric opening of the homopentameric 5-HT3A serotonin receptor in lipid bilayers

Horst Vogel, Shuguang Yuan

Pentameric ligand-gated ion channels (pLGICs) of the Cys-loop receptor family are key players in fast signal transduction throughout the nervous system. They have been shown to be modulated by the lipid environment, however the underlying mechanism is not ...

Nature Research2021

NREM sleep stages specifically alter dynamical integration of large-scale brain networks

Dimitri Nestor Alice Van De Ville, Anjali Bagunu Tarun

Functional dissociations in the brain observed during non-rapid eye movement (NREM) sleep have been associated with reduced information integration and impaired consciousness that accompany increasing sleep depth. Here, we explored the dynamical properties ...

CELL PRESS2021

Integrating non-visual effects of light in the automated daylight-responsive control of blinds and electric lighting

Marta Benedetti

The use of daylight in buildings is important because it contributes to energy savings by reducing the use of electric lighting and space heating. It also impacts on biological functions and on well-being. Indeed, light not only allows vision, but has non- ...

EPFL2021

Electrochemical determination of nicotine in smokers' sweat

Sandro Carrara, Tugba Kilic

In this work, we report the demonstration of the capability of electrochemical sensors to provide measurements directly on the sweat of volunteers to successfully discriminate heavy smokers by light ones. Since its importance as pharmaceutical treatment-ag ...

ELSEVIER2020

Accuracy of Molecular Simulation-Based Predictions of k(off) Values: A Metadynamics Study

Ursula Röthlisberger, Michele Parrinello, Paolo Carloni, Simone Meloni, Viacheslav Bolnykh

The k(off) values of ligands unbinding to proteins are key parameters for drug discovery. Their predictions based on molecular simulation may under- or overestimate experiment in a system- and/or technique-dependent way. Here we use an established method-i ...

AMER CHEMICAL SOC2020

Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans

Johan Auwerx, Richardus Houtkooper

Background: Nicotinamide riboside (NR) is an NAD(+) precursor that boosts cellular NAD(+) concentrations. Preclinical studies have shown profound metabolic health effects after NR supplementation. ...

OXFORD UNIV PRESS2020

Cellular, Synaptic and Network Effects of Acetylcholine in the Neocortex

Henry Markram, Srikanth Ramaswamy, Daniel Keller, Cristina Colangelo, Polina Shichkova

The neocortex is densely innervated by basal forebrain (BF) cholinergic neurons. Long-range axons of cholinergic neurons regulate higher-order cognitive function and dysfunction in the neocortex by releasing acetylcholine (ACh). ACh release dynamically rec ...

2019

Associations between genetic variations and global motion perception

Michael Herzog

The cholinergic system is known to strongly modulate perceptual and cognitive processes, and the alpha7 subunit of the cholinergic nicotinic receptor (CHRNA7) is broadly expressed within the visual system. Here, we assessed whether genetic variations of CH ...

2019

Sleep-wake-driven and circadian contributions to daily rhythms in gene expression and chromatin accessibility in the murine cortex

Felix Naef, Maxime Jan, Jake Yeung, Ioannis Xenarios

The timing and duration of sleep results from the interaction between a homeostatic sleep-wake-driven process and a periodic circadian process, and involves changes in gene regulation and expression. Unraveling the contributions of both processes and their ...

National Academy of Sciences2019

Heart rate variability at bedtime predicts subsequent sleep features

Fiorenzo Artoni, Maria Paola Tramonti Fantozzi

Getting enough sleep during the night is important for preventing adverse short- and long-term health outcomes. The sympathetic-parasympathetic autonomic balance, characteristics of the pre-bed time resting period, correlates with sleep efficiency. We inve ...

IEEE2019