Lectures in course CH-335: Asymmetric synthesis and retrosynthesis

Explores the use of protecting groups in organic synthesis, emphasizing stability and selectivity.

Explores the importance of chirality, methods for generating enantiopure compounds, and the synthesis of enantio-enriched compounds.

Generation of Enantiopure Compounds

Explores the generation of enantiopure compounds, enantiomer separation, kinetic resolution, conformational analysis, and allylic tension.

Aromatic Compounds: Retrosynthesis Principles

Covers the retrosynthesis of aromatic compounds, focusing on basic principles and the synthesis route.

Conformational Analysis of Cyclohexane and Alkene Synthesis

Explores cyclohexane conformational analysis, alkene synthesis, and stereoelectronic effects in orbital interactions.

Retrosynthesis: Basic Principles

Covers the basic principles of retrosynthesis, focusing on disconnections C-X and C-C.

Stereoselective Synthesis: Transition States and Alkynes Reduction

Explores stereoselective synthesis, transition states, and alkynes reduction for achieving high selectivity.

Retrosynthesis: Basic Principles and Aromatic Compounds

Covers the basic principles of retrosynthesis and aromatic compounds in organic synthesis.

Retrosynthesis: Disconnections C-C

Covers the principles of retrosynthesis, focusing on disconnections C-C and functional group disconnections.

Stereoselective Synthesis: Wittig and Julia Reactions

Explores stereoselective synthesis through Wittig and Julia reactions, emphasizing reactivity and regioselectivity of carbocations and the use of borane derivatives.

Rétrosynthèse: Disconnections C-C to Functional Groups

Covers retrosynthesis principles, cross couplings, and functional group disconnections.

Asymmetric Synthesis: Hydroboration, Epoxidation, Regioselectivity

Explores asymmetric synthesis through hydroboration and epoxidation, emphasizing regioselectivity and stereoselectivity.

Retrosynthesis Principles of Carbocyclic Compounds

Covers retrosynthesis principles for carbocyclic compounds and selective reactivity of carbonyls and enolization.

Enantioselective Epoxidation: Sharpless Epoxidation

Explores enantioselective epoxidation using Ti(O'Pr)4 catalyst and optically active tatrate ester, emphasizing stereochemistry factors and nucleophile absence.

Retrosynthesis Principles: Carbocyclic Compounds

Covers the principles of retrosynthesis and the synthesis of carbocyclic compounds with cross couplings and selectivity control.

Asymmetric Synthesis: Carbonyl Additions and Chelation

Explores asymmetric synthesis through carbonyl additions and chelation, emphasizing selectivity and key concepts like Felkin-Anh model.

Asymmetric Synthesis: Concepts and Models

Covers reactions not following a specific model and directed reductions using boranes.

Strategies for Macrocyclic Compounds Synthesis

Covers strategies for the synthesis of macrocyclic compounds, focusing on DC disconnections and oxidation of alkenes.

Asymmetric Synthesis: Allylation and Enolate Synthesis

Explores asymmetric allylation and enolate synthesis using chiral auxiliaries for stéréosélective reactions.

Synthesis Strategies: Tamiflu

Covers the synthesis strategies for the active ingredient of Tamiflu, focusing on retrosynthesis and regioselective openings.