Publications by Adrian Schmid | EPFL Graph Search

Salivary Proteomics Identifies Transthyretin as a Biomarker of Early Dementia Conversion

Background: Alzheimer's disease (AD) remains to date an incurable disease with a long asymptomatic phase. Early diagnosis in peripheral biofluids has emerged as key for identifying subjects at risk and developing therapeutics and preventative approaches. ...

IOS PRESS2022

Stoichiometry of the Gene Products From the Tetrachloroethene Reductive Dehalogenase Operon pceABCT

Christof Holliger, Julien Maillard, Adrian Schmid, Lorenzo Cimmino

Organohalide respiration (OHR) is a bacterial anaerobic process that uses halogenated compounds, e.g., tetrachloroethene (PCE), as terminal electron acceptors. Our model organisms are Dehalobacter restrictus strain PER-K23, an obligate OHR bacterium (OHRB) ...

Frontiers Media SA2022

Antibody-based methods for the measurement of α-synuclein concentration in human cerebrospinal fluid - method comparison and round robin study

Hilal Lashuel, Adrian Schmid, Marc Moniatte

2019

Protocomputing Architecture over a Digital Medium Aiming at Real-Time Video Processing

Adrian Schmid

2018

Enhancing mitochondrial proteostasis reduces amyloid-beta proteotoxicity

Adrian Schmid, Johan Auwerx, Norman Lionel Moullan, Hongbo Zhang, Solene Rietsch, Vincenzo Sorrentino, Davide D'Amico, Mario Romani, Francesca Potenza

Alzheimer's disease is a common and devastating disease characterized by aggregation of the amyloid-beta peptide. However, we know relatively little about the underlying molecular mechanisms or how to treat patients with Alzheimer's disease. Here we provid ...

2017

Extension of least squares spectral resolution algorithm to high-resolution lipidomics data

Adrian Schmid

Lipidomics, which focuses on the global study of molecular lipids in biological systems, has been driven tremendously by technical advances in mass spectrometry (MS) instrumentation, particularly high-resolution MS. This requires powerful computational too ...

Elsevier2016

Amyloid-beta oligomerization is associated with the generation of a typical peptide fragment fingerprint

Cyntia De Piano, Nikita Rudinskiy, Adrian Schmid, Marc Moniatte, Davide Demurtas, Christophe Fuerer

Amyloid-beta (A beta) peptide oligomerization plays a central role in the pathogenesis of Alzheimer's disease (AD), and A beta oligomers are collectively considered an appealing therapeutic target for the treatment of AD. However, the molecular mechanisms ...

Elsevier Science Inc2016

Flagellar membranes are rich in raft-forming phospholipids

Adrian Schmid

The observation that the membranes of flagella are enriched in sterols and sphingolipids has led to the hypothesis that flagella might be enriched in raft-forming lipids. However, a detailed lipidomic analysis of flagellar membranes is not available. Novel ...

Company Of Biologists Ltd2015

Alpha-synuclein Post-translational Modifications as Potential Biomarkers for Parkinson Disease and Other Synucleinopathies

Bruno Claude Daniel Fauvet, Hilal Lashuel, Adrian Schmid, Marc Moniatte

The development of novel therapies against neurodegenerative disorders requires the ability to detect their early, presymptomatic manifestations in order to enable treatment before irreversible cellular damage occurs. Precocious signs indicative of neurode ...

Amer Soc Biochemistry Molecular Biology Inc2013

Tissue Transglutaminase-mediated Glutamine Deamidation of beta-Amyloid Peptide Increases Peptide Solubility, Whereas Enzymatic Cross-linking and Peptide Fragmentation May Serve as Molecular Triggers for Rapid Peptide Aggregation

Horst Vogel, Enrico Condemi, Adrian Schmid, Marc Moniatte, Diego Chiappe, Yury Tsybin

Tissue transglutaminase (TGase) has been implicated in a number of cellular processes and disease states, where the enzymatic actions of TGase may serve in both, cell survival and apoptosis. To date, the precise functional properties of TGase in cell survi ...

American Society for Biochemistry and Molecular Biology2011

Deamidation and Transamidation of Substance P by Tissue Transglutaminase Revealed by Electron-Capture Dissociation Fourier Transform Mass Spectrometry (Chem. Eur. J. 2/2011)

Horst Vogel, Luigino Grasso, Adrian Schmid, Yury Tsybin, Luca Fornelli

Tissue transglutaminase (tTGase) catalyzes both deamidation and transamidation of peptides and proteins by using a peptidyl glutamine as primary substrate. A precise consensus sequence for the enzyme is unknown and the ratio between deamidated and transami ...

Wiley-Blackwell2011

Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions

Patrick Aebischer, Bernard Schneider, Hilal Lashuel, Adrian Schmid, Marc Moniatte, Diego Chiappe, Abid Oueslati, Magdalena Zweckstetter

Increasing evidence suggests that phosphorylation may play an important role in the oligomerization, fibrillogenesis, Lewy body (LB) formation, and neurotoxicity of alpha-synuclein (alpha-syn) in Parkinson disease. Herein we demonstrate that alpha-syn is p ...

2010

Disruption of amyloid-derived peptide assemblies through the controlled induction of a beta-sheet to alpha-helix transformation: application of the switch concept

Richard Alan Mimna, Marie-Stéphanie Camus, Hilal Lashuel, Adrian Schmid

Reversal of amyloid formation through a controlled induced transformation from beta-sheet to sol. alpha-helix structures through the use of a switch element S could have an important consequences understanding the mechanisms of amyloid formation and cleara ...

Wiley-VCH Verlag GmbH2007

Switch-peptides as folding precursors in self-assembling peptides and amyloid fibrillogenesis

Karine Murat, Jérémy Bérard, Richard Alan Mimna, Marie-Stéphanie Camus, Hilal Lashuel, Adrian Schmid

The study of conformational transitions of peptides has obtained considerable attention recently because of their importance as a mol. key event in a variety of degenerative diseases. However, the study of peptide self-assembly into beta-sheets and amyloid ...

2007