Publications by Jean-David Horacio Morel

Porphyran from discolored nori prevents metabolic syndrome through microbiota-bile acid-ceramide pathway

Johan Auwerx, Adrienne Joëlle Laurence Mottis, Alessia Perino, Jean-David Horacio Morel

Nori is a component of the traditional Japanese diet. The Japanese have a low prevalence of obesity and cardiovascular disease worldwide, and components of nori may have disease-preventive effects. Here, we focused on porphyran, which is abundant in nori t ...

2025

Systems genetics of metabolic health in the BXD mouse genetic reference population

Johan Auwerx, Maroun Bou Sleiman, Wen Gao, Jean-David Horacio Morel, Xiaoxu Li, Alessia De Masi, Amélia Lalou, Jia Liu

Susceptibility to metabolic syndrome (MetS) is dependent on genetics, environment, and gene-by-environment interactions, rendering the study of underlying mechanisms challenging. The majority of experiments in model organisms do not incorporate genetic var ...

2024

High-content phenotypic analysis of a C. elegans recombinant inbred population identifies genetic and molecular regulators of lifespan

Elena Katsyuba, Johan Auwerx, Laurent Mouchiroud, Maroun Bou Sleiman, Yang Li, Gaby El Alam, Wen Gao, Jean-David Horacio Morel, Xiaoxu Li, Amélia Lalou

Lifespan is influenced by complex interactions between genetic and environmental factors. Studying those factors in model organisms of a single genetic background limits their translational value for humans. Here, we mapped lifespan determinants in 85 C. e ...

2024

Safe and Orally Bioavailable Inhibitor of Serine Palmitoyltransferase Improves Age-Related Sarcopenia

Johan Auwerx, Jean-David Horacio Morel, Alessia De Masi, Tanes Imamura de Lima, Sandra Rodriguez Lopez

The accumulation of ceramides and related metabolites has emerged as a pivotal mechanism contributing to the onset of age-related diseases. However, small molecule inhibitors targeting the ceramide de novo synthesis pathway for clinical use are currently u ...

2024

Sodium ferrous citrate and 5-aminolevulinic acid improve type 2 diabetes by maintaining muscle and mitochondrial health

Johan Auwerx, Jean-David Horacio Morel

ObjectiveImproving mitochondrial function is a promising strategy for intervention in type 2 diabetes mellitus. This study investigated the preventive effects of sodium ferrous citrate (SFC) and 5-aminolevulinic acid phosphate (ALA) on several metabolic dy ...

WILEY2023

The genetic background shapes the susceptibility to mitochondrial dysfunction and NASH progression

Johan Auwerx, Alexis Maximilien Bachmann, Maroun Bou Sleiman, Giacomo Vincenzo Giorgio Von Alvensleben, Jean-David Horacio Morel, Ludger Jan Elzuë Goeminne, Sandra Rodriguez Lopez

Mice from different genetic backgrounds have widely diverse responses to the same metabolic challenges. Only PWK/PhJ mice show significant mitochondrial dysfunction and progression to fibrotic NASH that resembles human NASH. The PWK/PhJ strain is a novel N ...

ROCKEFELLER UNIV PRESS2023

Learning from the past: A short term forecast method for the COVID-19 incidence curve

Jean-David Horacio Morel

Author summaryForecasting the short time evolution of the COVID-19 daily incidence is a key issue in the epidemic decision making policy. We propose a machine learning method which forecasts the future values of the daily incidence trend based on the evolu ...

PUBLIC LIBRARY SCIENCE2023

Inhibiting de novo ceramide synthesis restores mitochondrial and protein homeostasis in muscle aging

Johan Auwerx, Hao Li, Mario Romani, Dohyun Park, Pirkka-Pekka Untamo Laurila, Changmyung Oh, Martin Rainer Wohlwend, Jean-David Horacio Morel, Xiaoxu Li, Ludger Jan Elzuë Goeminne, Tanes Imamura de Lima, Sandra Rodriguez Lopez, Barbara Moreira Crisol

Disruption of mitochondrial function and protein homeostasis plays a central role in aging. However, how these processes interact and what governs their failure in aging remain poorly understood. Here, we showed that cer- amide biosynthesis controls the de ...

AMER ASSOC ADVANCEMENT SCIENCE2023

Time warping between main epidemic time series in epidemiological surveillance

Jean-David Horacio Morel

The most common reported epidemic time series in epidemiological surveillance are the daily or weekly incidence of new cases, the hospital admission count, the ICU admission count, and the death toll, which played such a prominent role in the struggle to m ...

Public Library Science2023

Mitochondrial and NAD plus metabolism predict recovery from acute kidney injury in a diverse mouse population

Johan Auwerx, Alexis Maximilien Bachmann, Maroun Bou Sleiman, Giacomo Vincenzo Giorgio Von Alvensleben, Dina Hofer, Yang Li, Jean-David Horacio Morel

Acute kidney failure and chronic kidney disease are global health issues steadily rising in incidence and prevalence. Animal models on a single genetic background have so far failed to recapitulate the clinical presentation of human nephropathies. Here, we ...

AMER SOC CLINICAL INVESTIGATION INC2023

Genetic and dietary modulators of the inflammatory response in the gastrointestinal tract of the BXD mouse genetic reference population

Alexis Rapin, Kristina Schoonjans, Johan Auwerx, Alexis Maximilien Bachmann, Maroun Bou Sleiman, Alessia Perino, Jean-David Horacio Morel, Xiaoxu Li

Inflammatory gut disorders, including inflammatory bowel disease (IBD), can be impacted by dietary, environmental, and genetic factors. While the incidence of IBD is increasing worldwide, we still lack a complete understanding of the gene-by-environment in ...

2023

The mouse metallomic landscape of aging and metabolism

Johan Auwerx, Richardus Houtkooper, Evan Graehl Williams, Pooja Jha, Jean-David Horacio Morel, Ludger Jan Elzuë Goeminne

The metallome is crucial for normal cell functioning but remains largely overlooked in mammals. Here the authors analyze the metallome and copper and zinc isotope compositions in aging mice and show networks of interactions that are organ-specific, age-dep ...

Nature Research2022

Modeling COVID-19 Incidence by the Renewal Equation after Removal of Administrative Bias and Noise

Jean-David Horacio Morel

The sanitary crisis of the past two years has focused the public's attention on quantitative indicators of the spread of the COVID-19 pandemic. The daily reproduction number R-t, defined by the average number of new infections caused by a single infected i ...

MDPI2022

The Genetic Background Shapes Disease Susceptibility And Reveals A Specific Role For Mitochondrial Dysfunction In The Progression From Nafld To Nash

Johan Auwerx, Alexis Maximilien Bachmann, Maroun Bou Sleiman, Giacomo Vincenzo Giorgio Von Alvensleben, Jean-David Horacio Morel, Sandra Rodriguez Lopez, Jia Liu

WILEY2022

Computing the daily reproduction number of COVID-19 by inverting the renewal equation using a variational technique

Jean-David Horacio Morel

The COVID-19 pandemic has undergone frequent and rapid changes in its local and global infection rates, driven by governmental measures or the emergence of new viral variants. The reproduction number Rt indicates the average number of cases generated by an ...

National Academy of Sciences2021