Publications de Anna Claire Groner

Peripuberty stress leads to abnormal aggression, altered amygdala and orbitofrontal reactivity and increased prefrontal MAOA gene expression

Pierre Magistretti, Maria del Carmen Sandi Perez, Maria Isabel Cordero Campana, Didier Trono, Anna Claire Groner, Cristina Marquez Vega, Guillaume Poirier

Although adverse early life experiences have been found to increase lifetime risk to develop violent behaviors, the neurobiological mechanisms underlying these long-term effects remain unclear. We present a novel animal model for pathological aggression in ...

Nature Publishing Group2013

A gene-rich, transcriptionally active environment and the pre-deposition of repressive marks are predictive of susceptibility to KRAB/KAP1-mediated silencing

Philipp Bucher, Didier Trono, Sylvain Meylan, Anna Claire Groner, Annamaria Kauzlaric, Giovanna Ambrosini, Adamantia Kapopoulou, Jacques Rougemont, Nadine Fournier

BACKGROUND: KRAB-ZFPs (Kruppel-associated box domain-zinc finger proteins) are vertebrate-restricted transcriptional repressors encoded in the hundreds by the mouse and human genomes. They act via an essential cofactor, KAP1, which recruits effectors respo ...

BioMed Central2011

Studies on KRAB/KAP1-Mediated Transcriptional Repression

Anna Claire Groner

The sequencing of the human genome revealed that the C2H2-zinc finger proteins (ZFPs) are the largest family of human transcription factors. Around 300 members of this family contain, in addition to their zinc finger motifs, a KRAB domain that has been imp ...

EPFL2011

KRAB-Zinc Finger Proteins and KAP1 Can Mediate Long-Range Transcriptional Repression through Heterochromatin Spreading

Philipp Bucher, Nicolas Dénervaud, Didier Trono, Sylvain Meylan, Anna Claire Groner, Giovanna Ambrosini, Nadine Fournier

Krüppel-associated box domain-zinc finger proteins (KRAB-ZFPs) are tetrapod-specific transcriptional repressors encoded in the hundreds by the human genome. In order to explore their as yet ill-defined impact on gene expression, we developed an ectopic rep ...

Public Library of Science2010

Regulation of Episomal Gene Expression by KRAB/KAP1-Mediated Histone Modifications

Patrick Aebischer, Vivianne Padrun, Christopher Towne, Didier Trono, Isabelle Barde, Sonia Verp, Anna Claire Groner

KAP1 is an essential cofactor of KRAB zinc finger proteins, a family of vertebrate-specific epigenetic repressors of largely unknown functions encoded in the hundreds by the mouse and human genomes. So far, KRAB/KAP1-mediated gene regulation has been studi ...

American Society for Microbiology2009

KAP1-mediated epigenetic repression in the forebrain modulates behavioral vulnerability to stress

Jean-Charles Bensadoun, Maria del Carmen Sandi Perez, Maria Isabel Cordero Campana, Reto Bisaz, Didier Trono, Johan Jakobsson, Anna Claire Groner

KAP1 is an essential cofactor of KRAB-zinc finger proteins, a family of vertebrate-specific epigenetic repressors of largely unknown functions encoded in the hundreds by the mouse and human genomes. Here, we report that KAP1 is expressed at high levels and ...

2008