Publications related to Outline of life extension

L'aménagement du territoire comme espace public : quelques questions de démocratie locale posées par l’extension de l’École hôtelière dans le périurbain lausannois

Vincent Kaufmann, Luca Giovanni Pattaroni, Mischa-Sébastien Piraud

Based on a field survey on the conflicts regarding the extension of the Ecole Hôtelière de Lausanne, this text discusses the production of public space. These controversies make possible an understanding of the production process of peri-urban space in ter ...

2022

Gene replacement therapy provides benefit in an adult mouse model of Leigh syndrome

Johan Auwerx

Mutations in nuclear-encoded mitochondrial genes are responsible for a broad spectrum of disorders among which Leigh syndrome is the most common in infancy. No effective therapies are available for this severe disease mainly because of the limited capabili ...

2020

Statistical Fatigue Investigation and Failure Prediction of a Healable Composite System

Véronique Michaud, Amaël Maximilien Cohades, Nathan Klaus Hostettler

Fiber reinforced polymers are massively used as an alternative to metals in structural applications. The brittle nature of their matrix, however, makes them more susceptible to crack formation and propagation resulting in costly repair operations and incre ...

2020

Multi-omics reveals abundant mitochondrial genomic and circadian expression variation in the Drosophila Genetic Reference Panel

Maria Litovchenko

Modern biology rapidly generates a wealth of data,which can only be analysed computationally.Despite the variety of available data types,most of them aim to provide an answer to one question: how does genotypic diversity translates into phenotypes? This qu ...

EPFL2020

Systems Phytohormone Responses to Mitochondrial Proteotoxic Stress

Johan Auwerx, Xu Wang

Mitochondrial function is controlled by two separate genomes. This feature makes mitochondria prone to proteotoxic stress when a stoichiometric imbalance occurs in the protein complexes that perform oxidative phosphorylation, which consist of both nucleara ...

Cell Press2017

Enhancing mitochondrial proteostasis reduces amyloid-beta proteotoxicity

Johan Auwerx, Davide D'Amico, Adrian Schmid, Mario Romani, Norman Lionel Moullan, Vincenzo Sorrentino, Hongbo Zhang, Francesca Potenza, Solene Rietsch

Alzheimer's disease is a common and devastating disease characterized by aggregation of the amyloid-beta peptide. However, we know relatively little about the underlying molecular mechanisms or how to treat patients with Alzheimer's disease. Here we provid ...

2017

Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity

Johan Auwerx, Laurent Mouchiroud, Evan Graehl Williams, Virginija Jovaisaite

Across eukaryotic species, mild mitochondrial stress can have beneficial effects on the lifespan of organisms. Mitochondrial dysfunction activates an unfolded protein response (UPR(mt)), a stress signaling mechanism designed to ensure mitochondrial homeost ...

Cell Press2016

Mitonuclear protein imbalance as a conserved longevity mechanism

Johan Auwerx, Graham Knott, Laurent Mouchiroud, Richardus Houtkooper, Dongryeol Ryu, Elena Katsyuba, Norman Lionel Moullan

Longevity is regulated by a network of closely linked metabolic systems. We used a combination of mouse population genetics and RNA interference in Caenorhabditis elegans to identify mitochondrial ribosomal protein S5 (Mrps5) and other mitochondrial riboso ...

Nature Publishing Group2013

A three-state model for the regulation of telomerase by TERRA and hnRNPA1

Joachim Lingner, Sophie Redon, Ivo Zemp

Telomeres, the physical ends of eukaryotic chromosomes, are transcribed into telomeric repeat-containing RNA (TERRA), a large non-coding RNA, which forms an integral part of telomeric heterochromatin. In vitro, naked TERRA molecules are efficient inhibitor ...

Oxford University Press2013

A Quantitative Telomeric Chromatin Isolation Protocol (Q-TIP) to Characterize Telomere Composition Changes

Larissa Grolimund

Telomeres protect linear ends of eukaryotic chromosomes by preventing chromosomal end-to-end fusions and telomere attrition. They consist of repetitive DNA sequences, telomeric repeat containing RNAs (TERRAs) and proteins. Telomeres play a crucial role in ...

EPFL2013

SRT1720 improves survival and healthspan of obese mice

Johan Auwerx, Carlos Canto Alvarez

Sirt1 is an NAD1-dependent deacetylase that extends lifespan in lower organisms and improves metabolism and delays the onset of age-related diseases in mammals. Here we show that SRT1720, a synthetic compound that was identified for its ability to activate ...

Nature Publishing Group2011

Models of non-relativistic quantum gravity: the good, the bad and the healthy

Sergey Sibiryakov, Diego Blas Temino

Horava's proposal for non-relativistic quantum gravity introduces a preferred time foliation of space-time which violates the local Lorentz invariance. The foliation is encoded in a dynamical scalar field which we call 'khronon'. The dynamics of the khrono ...

Springer Nature2011

Horava gravity versus thermodynamics: The black hole case

Sergey Sibiryakov, Diego Blas Temino

Under broad assumptions, breaking of Lorentz invariance in gravitational theories leads to tension with unitarity because it allows for processes that apparently violate the second law of thermodynamics. The crucial ingredient of this argument is the exist ...

American Physical Society2011

Human telomerase RNA accumulation in cajal bodies facilitates telomerase recruitment to telomeres and telomere elongation

Joachim Lingner, Katarzyna Sikora

Telomerase is required for telomere maintenance and is responsible for the immortal phenotype of cancer cells. How telomerase is assembled and reaches telomeres in the context of nuclear architecture is not understood. Recently, the telomerase RNA subunit ...

2007

Telomerase repeat addition processivity is increased at critically short telomeres in a Tel1-dependent manner in Saccharomyces cerevisiae

Joachim Lingner

Telomerase is the ribonucleoprotein enzyme that elongates telomeres to counteract telomere shortening. The core enzyme consists of a reverse transcriptase protein subunit and an RNA subunit. The RNA subunit contains a short region that is used as a templat ...

2007